Výsledky vyhledávání - "Alina Gilgur"

Lefty Glycoproteins in Human Embryonic Stem Cells: Extracellular Delivery Route and Posttranslational Modification in Differentiation

Autor: Elisabeth A. Seftor, Mary J.C. Hendrix, Alina Gilgur, Yekaterina Galat, Zhila Khalkhali-Ellis, Vasiliy Galat

Publikováno v: Stem Cells and Development. 25:1681-1690

Lefty is a member of transforming growth factor-beta (TGF-β) superfamily and a potent antagonist of the TGF-β/Nodal/Activin signaling pathway. Lefty is critical in sustaining self-renewal/pluripotency status, and implicated in the differentiation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98063ce3602968a084ac729ef212bda
https://doi.org/10.1089/scd.2016.0081

Zobrazit plný text záznamu

Nodal expression in triple-negative breast cancer: Cellular effects of its inhibition following doxorubicin treatment

Autor: Grace S. Chandler, Thomas M. Bodenstine, Naira V. Margaryan, Mary J.C. Hendrix, Luigi Strizzi, Nida Ahmed, Alina Gilgur, Elisabeth A. Seftor, Matthew Hyser, David W. Reed, Janis Atkinson

Publikováno v: Cell Cycle. 15:1295-1302

Triple-negative breast cancer (TNBC) represents an aggressive cancer subtype characterized by the lack of expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). The independence of TNBC f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6e0e2ebac2f275cb19fd2d8b9d1ffd0
https://doi.org/10.1080/15384101.2016.1160981

Zobrazit plný text záznamu

Effects of a novel Nodal-targeting monoclonal antibody in melanoma

Autor: Naira V. Margaryan, Alina Gilgur, Luigi Strizzi, Antonio Leonardi, Thomas M. Bodenstine, Zhila Khalkhali-Ellis, Luca Sanguigno, Annamaria Sandomenico, Annalia Focà, Menotti Ruvo, David W. Reed, Richard E.B. Seftor, Grace S. Chandler, Elisabeth A. Seftor, Mary J.C. Hendrix

Publikováno v: Oncotarget

Nodal is highly expressed in various human malignancies, thus supporting the rationale for exploring Nodal as a therapeutic target. Here, we describe the effects of a novel monoclonal antibody (mAb), 3D1, raised against human Nodal. In vitro treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed7e514516200e848cfcd72863df463
https://doi.org/10.18632/oncotarget.6049

Zobrazit plný text záznamu

Divergence(s) in nodal signaling between aggressive melanoma and embryonic stem cells

Autor: Mary J.C. Hendrix, Alina Gilgur, Elisabeth A. Seftor, Thomas M. Bodenstine, Andrew P. Hinck, Zhila Khalkhali-Ellis, Dawn A. Kirschmann

Publikováno v: International Journal of Cancer. 136:E242-E251

The significant role of the embryonic morphogen Nodal in maintaining the pluripotency of embryonic stem cells is well documented. Interestingly, the recent discovery of Nodal's re-expression in several aggressive and metastatic cancers has highlighte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87f9ea6eb86100197c493392db918c9d
https://doi.org/10.1002/ijc.29198

Zobrazit plný text záznamu

Nodal signaling promotes a tumorigenic phenotype in human breast cancer

Autor: Gina Kirsammer, Matthew Hyser, Mary J.C. Hendrix, Elisabeth A. Seftor, Naira V. Margaryan, Luigi Strizzi, Janis Atkinson, Alina Gilgur, Dawn A. Kirschmann

Publikováno v: Seminars in cancer biology. 29

The Ras-ERK pathway is deregulated in approximately a third of human cancers, particularly those of epithelial origin. In aggressive, triple-negative, basal-like breast cancers, most tumors display increased MEK and ERK phosphorylation and exhibit a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580bc0efb194978373a052740810e75e
https://pubmed.ncbi.nlm.nih.gov/25073112

Zobrazit plný text záznamu

Melanoma Tumor Cell Heterogeneity: A Molecular Approach to Study Subpopulations Expressing the Embryonic Morphogen Nodal

Autor: Gina Kirsammer, Elisabeth A. Seftor, Alina Gilgur, Mary J.C. Hendrix, Naira V. Margaryan, Don Weldon, Richard E.B. Seftor

As the frequency of melanoma increases, current treatment strategies are struggling to significantly impact patient survival. One of the critical issues in designing efficient therapies is understanding the composition of heterogeneous melanoma tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907875aa3739c6a970d8111d570eafef
https://europepmc.org/articles/PMC4026856/

Zobrazit plný text záznamu

The significance of a Cripto-1 positive subpopulation of human melanoma cells exhibiting stem cell-like characteristics

Autor: David S. Salomon, Naira V. Margaryan, Alina Gilgur, Nicola Normanno, Luigi Strizzi, Katharine M. Hardy, Mary J.C. Hendrix

Publikováno v: Cell cycle (Georgetown, Tex.). 12(9)

Cripto-1 (CR-1) protein function differs according to cellular or extracellular expression. In this study, we explore the significance of cell surface CR-1 expression in human melanoma cells. Cell surface CR-1-expressing human melanoma cells (CR1-CS+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60134f5324fd6f8d0bba27c9af310e55
https://pubmed.ncbi.nlm.nih.gov/23574716

Zobrazit plný text záznamu

Melanocytes Affect Nodal Expression and Signaling in Melanoma Cells: A Lesson from Pediatric Large Congenital Melanocytic Nevi

Autor: Mary J.C. Hendrix, Elisabeth A. Seftor, Nicoleta C. Arva, Alina Gilgur, Naira V. Margaryan, Chad A. Purnell, Luigi Strizzi, Arun K. Gosain

Publikováno v: International Journal of Molecular Sciences; Volume 17; Issue 3; Pages: 418
International Journal of Molecular Sciences, Vol 17, Iss 3, p 418 (2016)
International Journal of Molecular Sciences

Expression of Nodal, a Transforming Growth Factor-beta (TGF-β) related growth factor, is associated with aggressive melanoma. Nodal expression in adult dysplastic nevi may predict the development of aggressive melanoma in some patients. A subset of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51b0235f8e278f972b74b30ced45d13
https://doi.org/10.3390/ijms17030418

Zobrazit plný text záznamu

Abstract 4378: Targeting the embryonic morphogen Nodal reduces viability of doxorubicin-treated breast cancer cells in vitro

Autor: Grace S. Chandler, Alina Gilgur, Luigi Strizzi, Mary J.C. Hendrix, Elisabeth A. Seftor, Andrew P. Mazar, Thomas M. Bodenstine, Zhila Khalkhali-Ellis, Andrey Ugolkov, Naira V. Margaryan, Richard E.B. Seftor

Publikováno v: Cancer Research. 75:4378-4378

Triple negative breast cancer represents an aggressive malignancy for which few targeted therapies exist. The embryonic morphogen Nodal is re-expressed in highly aggressive breast cancers and reduction of Nodal signaling decreases tumor cell metastat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93c2ea9d7e143f0edf428bcbf276433c
https://doi.org/10.1158/1538-7445.am2015-4378

Zobrazit plný text záznamu

Abstract 3353: Nodal signaling mediates the aggressive, tumorigenic phenotype in breast cancer cells

Autor: Naira V. Margaryan, Gina Kirsammer, Elisabeth A. Seftor, Dawn A. Kirschmann, Luigi Strizzi, Mary J.C. Hendrix, Alina Gilgur

Publikováno v: Cancer Research. 72:3353-3353

The embryonic morphogen Nodal is a potent inducer of EMT and critical mediator of stem cell pluripotency in the developing embryo, but is not expressed in normal adult tissues. Intriguingly, our lab has recently shown that Nodal, a TGF-beta family me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa9a792f31c595f6761636945d6538f4
https://doi.org/10.1158/1538-7445.am2012-3353

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání