Secondary structure of the human mitochondrial genome affects formation of deletions

Autor: Victor Shamanskiy, Alina A. Mikhailova, Evgenii O. Tretiakov, Kristina Ushakova, Alina G. Mikhailova, Sergei Oreshkov, Dmitry A. Knorre, Natalia Ree, Jonathan B. Overdevest, Samuel W. Lukowski, Irina Gostimskaya, Valerian Yurov, Chia-Wei Liou, Tsu-Kung Lin, Wolfram S. Kunz, Alexandre Reymond, Ilya Mazunin, Georgii A. Bazykin, Jacques Fellay, Masashi Tanaka, Konstantin Khrapko, Konstantin Gunbin, Konstantin Popadin

Publikováno v: BMC Biology, Vol 21, Iss 1, Pp 1-13 (2023)

Abstract Background Aging in postmitotic tissues is associated with clonal expansion of somatic mitochondrial deletions, the origin of which is not well understood. Such deletions are often flanked by direct nucleotide repeats, but this alone does no

Externí odkaz: https://doaj.org/article/4165b20a8937424aafa2ba2a950a3360

A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand

Autor: Alina G Mikhailova, Alina A Mikhailova, Kristina Ushakova, Evgeny O Tretiakov, Dmitrii Iliushchenko, Victor Shamansky, Valeria Lobanova, Ivan Kozenkov, Bogdan Efimenko, Andrey A Yurchenko, Elena Kozenkova, Evgeny M Zdobnov, Vsevolod Makeev, Valerian Yurov, Masashi Tanaka, Irina Gostimskaya, Zoe Fleischmann, Sofia Annis, Melissa Franco, Kevin Wasko, Stepan Denisov, Wolfram S Kunz, Dmitry Knorre, Ilya Mazunin, Sergey Nikolaev, Jacques Fellay, Alexandre Reymond, Konstantin Khrapko, Konstantin Gunbin, Konstantin Popadin

Publikováno v: Denisov, S 2022, ' A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand ', Nucleic acids research, vol. 50, pp. 10264–10277 . https://doi.org/10.1093/nar/gkac779

The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the known mutational signatures of the nuclear genome and variation in mtDNA mutational spectra between different organisms is still incomprehensible. Since mitochondri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aaf04f68180d9afc181527a26230b3c
https://doi.org/10.1093/nar/gkac779

Risk of mitochondrial deletions is affected by the global secondary structure of the human mitochondrial genome

Autor: Victor Shamanskiy, Alina A. Mikhailova, Kristina Ushakova, Alina G. Mikhailova, Sergei Oreshkov, Dmitry Knorre, Evgenii O. Tretiakov, Natalia Ri, Jonathan B. Overdevest, Samuel W. Lukowski, Irina Gostimskaya, Valerian Yurov, Chia-Wei Liou, Tsu-Kung Lin, Wolfram S. Kunz, Alexandre Reymond, Ilya Mazunin, Georgii A. Bazykin, Konstantin Gunbin, Jacques Fellay, Masashi Tanaka, Konstantin Khrapko, Konstantin Popadin

Aging in postmitotic tissues is associated with clonal expansion of somatic mitochondrial deletions, the origin of which is not well understood. Deletions in mitochondrial DNA (mtDNA) are often flanked by direct nucleotide repeats, but this alone doe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b7b41d63cb530114b932e2ac1ae70e6
https://doi.org/10.1101/603282