Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling

Autor: Amika Singla, Alina Fedoseienko, Sai S. P. Giridharan, Brittany L. Overlee, Adam Lopez, Da Jia, Jie Song, Kayci Huff-Hardy, Lois Weisman, Ezra Burstein, Daniel D. Billadeau

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

Recycling of proteins that have entered the endosome is essential to homeostasis. The COMMD/CCDC22/CCDC93 (CCC) complex is regulator of recycling but the molecular mechanisms are unclear. Here, the authors report that the CCC complex regulates endoso

Externí odkaz: https://doaj.org/article/05e31276e2a744fdb7699f4e17f5be4d

Regulation of murine copper homeostasis by members of the COMMD protein family

Autor: Amika Singla, Qing Chen, Kohei Suzuki, Jie Song, Alina Fedoseienko, Melinde Wijers, Adam Lopez, Daniel D. Billadeau, Bart van de Sluis, Ezra Burstein

Publikováno v: Disease Models & Mechanisms, Vol 14, Iss 1 (2021)

Copper is an essential transition metal for all eukaryotes. In mammals, intestinal copper absorption is mediated by the ATP7A copper transporter, whereas copper excretion occurs predominantly through the biliary route and is mediated by the paralog A

Externí odkaz: https://doaj.org/article/ea4bf9db661d434e92aa53cbc188905f

Nuclear COMMD1 Is Associated with Cisplatin Sensitivity in Ovarian Cancer.

Autor: Alina Fedoseienko, Hylke W Wieringa, G Bea A Wisman, Evelien Duiker, Anna K L Reyners, Marten H Hofker, Ate G J van der Zee, Bart van de Sluis, Marcel A T M van Vugt

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0165385 (2016)

Copper metabolism MURR1 domain 1 (COMMD1) protein is a multifunctional protein, and its expression has been correlated with patients' survival in different types of cancer. In vitro studies revealed that COMMD1 plays a role in sensitizing cancer cell

Externí odkaz: https://doaj.org/article/34a04406c6ee4dfaadf1962699b0b1fe

The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking

Autor: Marten H. Hofker, Johannes H.M. Levels, Marieke Smit, Ko Willems van Dijk, Ezra Burstein, Melinde Wijers, Helene Klug, Jan Albert Kuivenhoven, Alina Fedoseienko, Daphne Dekker, Daniel D. Billadeau, Nicolette C. A. Huijkman, Jan M. van Deursen, Justina C. Wolters, Marit Westerterp, Bart van de Sluis, Niels J. Kloosterhuis, Aloys Schepers

Publikováno v: Circulation research, 122(12), 1648-1660. LIPPINCOTT WILLIAMS & WILKINS
Circulation Research, 122, 12, pp. 1648-1660
Circulation Research, 122(12), 1648-1660
Circulation Research, 122, 1648-1660
Circ. Res. 122, 1648-1660 (2018)
Circulation research, 122(12), 1648-1660. Lippincott Williams and Wilkins

Rationale: COMMD (copper metabolism MURR1 domain)-containing proteins are a part of the CCC (COMMD–CCDC22 [coiled-coil domain containing 22]–CCDC93 [coiled-coil domain containing 93]) complex facilitating endosomal trafficking of cell surface rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a925a79fb71696da5ff2af42e11748de
https://research.rug.nl/en/publications/2aa5eb9b-69a5-436e-ac96-13a4c9a2720e

Nuclear COMMD1 Is Associated with Cisplatin Sensitivity in Ovarian Cancer

Autor: Anna K.L. Reyners, Ate G.J. van der Zee, Evelien W. Duiker, Alina Fedoseienko, G. Bea A. Wisman, Hylke W. Wieringa, Marcel A. T. M. van Vugt, Marten H. Hofker, Bart van de Sluis

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0165385 (2016)
PLoS ONE
PLoS ONE, 11(10):e0165385. PUBLIC LIBRARY SCIENCE

Copper metabolism MURR1 domain 1 (COMMD1) protein is a multifunctional protein, and its expression has been correlated with patients' survival in different types of cancer. In vitro studies revealed that COMMD1 plays a role in sensitizing cancer cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f69075276c649041800b62d371b9081
https://doi.org/10.1371/journal.pone.0165385