Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Alina Berdichevsky"'
Autor:
Rui Zheng, Douglas C. Bauer, Justin Yik Ching Mao, Qian Liu, Vasumathy Miduturu, Richard Zessis, Frédéric Zecri, Qingming Zhu, Panos Hatsis, Benjamin Hoogheem, Xin Chen, Ryan Scott Streeper, Sejal Patel, Rohit Duvadie, Tyler Harrison, Erik C. Rocheford, Alina Berdichevsky
Publikováno v:
ACS Med Chem Lett
[Image: see text] Diacylglycerol O-acyltransferase 1 (DGAT1) inhibitor Pradigastat (1) was shown to be effective at decreasing postprandial triglyceride levels in a patient population with familial chylomicronemia syndrome (FCS). Although pradigastat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20abe8c9bf3e5908861a37faee171af8
https://doi.org/10.1021/acsmedchemlett.9b00117
https://doi.org/10.1021/acsmedchemlett.9b00117
Autor:
Gordon Turner, Jennifer Vogel, Sharon X. Wang, Thomas M. Smith, Brian DeChristopher, Jianning Yin, Liansheng Su, Amy Chen, Richard Zessis, Sena Fowler, Aaron C. Wilson, Alina Berdichevsky, Chun-Hao Chiu, Deborah M. Rothman, Frédéric Zecri, Heming Xing, Xinming Cai
Publikováno v:
Diabetes. 69(5)
Type 2 diabetes (T2D) is caused by loss of pancreatic β-cell mass and failure of the remaining β-cells to deliver sufficient insulin to meet demand. β-Cell glucolipotoxicity (GLT), which refers to combined, deleterious effects of elevated glucose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c674b2e08e9052708f657a01ebe1c44
https://pubmed.ncbi.nlm.nih.gov/32079579
https://pubmed.ncbi.nlm.nih.gov/32079579
Autor:
Konstantinos Boulias, Leonard Guarente, Simona Nedelcu, Alina Berdichevsky, Nicholas A. Bishop, H. Robert Horvitz
Publikováno v:
Proceedings of the National Academy of Sciences. 107:18927-18932
Studies of long-lived Caenorhabditis elegans mutants have identified several genes that function to limit lifespan, i.e., loss-of-function mutations in these genes promote longevity. By contrast, little is known about genes that normally act to delay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c8a12994c5cbd780aebe3a69d1022a
https://doi.org/10.1073/pnas.1013854107
https://doi.org/10.1073/pnas.1013854107
Publikováno v:
Journal of Biological Chemistry. 285:21581-21589
Chronic oxidative stress results in decreased responsiveness to insulin, eventually leading to diabetes and cardiovascular disease. Activation of the JNK signaling pathway can mediate many of the effects of stress on insulin resistance through inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d11665ff85562697d5d3b9b7ed92beb
https://doi.org/10.1074/jbc.m109.093633
https://doi.org/10.1074/jbc.m109.093633