Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Alina, Ghinet"'
Autor:
Pierre Popczyk, Alina Ghinet, Clovis Bortolus, Laure Kamus, Marc F. Lensink, Jérôme de Ruyck, Boualem Sendid, Faustine Dubar
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Worldwide, invasive candidiasis are a burden for the health system due to difficulties to manage patients, to the increasing of the resistance of the current therapeutics and the emergence of naturally resistant species of Candida. In this context, t
Externí odkaz:
https://doaj.org/article/0e82ed2741094669963e9b8c48798a28
Autor:
Naomi KNAVS, Andreea ZUBAŞ, Georgiana APOSTOL, Christophe FURMAN, Adrian Sorin NICA, Bezhan CHANKVETADZE, Alina GHINET, Emmanuelle LIPKA
Publikováno v:
Journal of Chromatography Open, Vol 5, Iss , Pp 100129- (2024)
Eleven polysaccharide-based chiral stationary phases were screened to separate stereoisomers of six lactam derivatives by supercritical fluid chromatography (SFC). Those molecules are antagonists of the P2×7 receptor with potential anti-inflammatory
Externí odkaz:
https://doaj.org/article/868d52519edd4a5aa8bb00a9fd5ac45f
Autor:
Serena Janho dit Hreich, Thierry Juhel, Sylvie Leroy, Alina Ghinet, Frederic Brau, Veronique Hofman, Paul Hofman, Valerie Vouret-Craviari
Publikováno v:
eLife, Vol 12 (2024)
Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease associated with progressive and irreversible deterioration of respiratory functions that lacks curative therapies. Despite IPF being associated with a dysregulated immune
Externí odkaz:
https://doaj.org/article/7d3df8fa9c874209bfde522c7a364128
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101451- (2024)
A new series of indazole-indolizine-triazine hybrid molecules was obtained by [3 + 2] cycloaddition reaction between newly synthesized nitrogen ylides with indazole skeleton and previously reported dipolarophile 2‐ethynyl‐4,6‐dimethoxy‐1,3,5
Externí odkaz:
https://doaj.org/article/d300f57c56c54066bbddb97d40ad34c2
Autor:
Samara Mejri, Alina Ghinet, Maryline Magnin-Robert, Béatrice Randoux, Cristina-Maria Abuhaie, Benoit Tisserant, Philippe Gautret, Benoit Rigo, Patrice Halama, Philippe Reignault, Ali Siah
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The current worldwide context promoting agroecology and green agriculture require the discovery of new ecofriendly and sustainable plant protection tools. Plant resistance inducers, called also elicitors, are one of the most promising altern
Externí odkaz:
https://doaj.org/article/9ce07d9bf20845aabec3bac52f7760de
Publikováno v:
Journal of Chromatography Open, Vol 2, Iss , Pp 100026- (2022)
The present paper describes the study of eight racemic γ-lactam derivatives with the goal of comparing three modes of liquid chromatography which are the reversed-phase mode, the normal-phase mode and the polar organic solvent chromatography mode wi
Externí odkaz:
https://doaj.org/article/a1a42fd2a69044ee8e608a568e7683f3
Publikováno v:
Pharmaceuticals, Vol 16, Iss 6, p 888 (2023)
In the search for innovative approaches to cancer chemotherapy, a chemical library of 49 cyanochalcones, 1a-r, 2a-o, and 3a-p, was designed as dual inhibitors of human farnesyltransferase (FTIs) and tubulin polymerization (MTIs) (FTIs/MTIs), two impo
Externí odkaz:
https://doaj.org/article/7a614bbe9e6449458fb251afebe52d6c
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 691 (2023)
In the context of a continuously increasing global cancer risk, the search for new effective and affordable anticancer drugs remains a constant demand. This study describes chemical experimental drugs able to destroy cancer cells by arresting their g
Externí odkaz:
https://doaj.org/article/0ca38055239c4c698bd5f1c5fc37f304
Autor:
Marie Hechelski, Christophe Waterlot, Pierrick Dufrénoy, Brice Louvel, Adam Daïch, Alina Ghinet
Publikováno v:
Green Chemistry Letters and Reviews, Vol 14, Iss 1, Pp 15-22 (2021)
Lolium perenne L., a common plant perennial ryegrass from Europe, northern Africa and Asia, was selected to produce biomass under field conditions. The biomass of this nonfood crop was from a highly contaminated agricultural soil by potentially toxic
Externí odkaz:
https://doaj.org/article/3aeb868108db40f9999e49af341e3ff6
Autor:
Laetitia Douguet, Serena Janho dit Hreich, Jonathan Benzaquen, Laetitia Seguin, Thierry Juhel, Xavier Dezitter, Christophe Duranton, Bernhard Ryffel, Jean Kanellopoulos, Cecile Delarasse, Nicolas Renault, Christophe Furman, Germain Homerin, Chloé Féral, Julien Cherfils-Vicini, Régis Millet, Sahil Adriouch, Alina Ghinet, Paul Hofman, Valérie Vouret-Craviari
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
A limited percentage of patients with non-small cell lung cancer respond to immunotherapy. Here the authors show that HEI3090, a chemical positive modulator of the purinergic P2RX7 receptor, promotes IL-18 mediated anti-tumor immune responses and sen
Externí odkaz:
https://doaj.org/article/d9f2cc20554a4d0e92405e7e329a31b4