Methods and software tools for design evaluation in population pharmacokinetics-pharmacodynamics

Autor: Nyberg, Joakim, Bazzoli, Caroline, Ogungbenro, Kayode, Aliev, Alexander, Leonov, Sergei, Duffull, Stephen, Hooker, Andrew, Mentré, France

Publikováno v: British Journal of Clinical Pharmacology
British Journal of Clinical Pharmacology, Wiley, 2015, Special Issue: Population Dynamics, 79 (1), pp.6-17. ⟨10.1111/bcp.12352⟩

International audience; Population Pharmacokinetic (PK)-Pharmacodynamic (PD) (PKPD) models are increasingly used in drug development and in academic research. Hence designing efficient studies is an important task. Following the first theoretical wor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e715d721b54cd1c1ca3dd40679cff746
https://hal.archives-ouvertes.fr/hal-00951896/document

Approximation of the Fisher Information Matrix for Nonlinear Mixed Effects Models in Population PK/PD Studies.

Autor: Leonov, Sergei, Aliev, Alexander

Publikováno v: mODa 10 - Advances in Model-Oriented Design & Analysis; 2013, p145-152, 8p