Immune responsiveness in stable kidney transplantation patients: Complete inhibition of T‐cell proliferation but residual T‐cell activity during maintenance immunosuppressive treatment

Autor: Aliede E. in ’t Veld, Boukje C. Eveleens Maarse, Maria J. Juachon, Soufian Meziyerh, Aiko P. J. deVries, Aline L. vanRijn, Mariet C. W. Feltkamp, Dirk Jan A. R. Moes, Jacobus Burggraaf, Matthijs Moerland

Publikováno v: Clinical and Translational Science, Vol 17, Iss 6, Pp n/a-n/a (2024)

Abstract The recommended immunosuppressive treatment after kidney transplantation consists of tacrolimus, mycophenolate mofetil, and low‐dose corticosteroids. Drug concentrations are monitored using therapeutic drug monitoring (TDM), which does not

Externí odkaz: https://doaj.org/article/2c90a61949794a7c82425755b1b0fcc7

Monitoring of Ex Vivo Cyclosporin a Activity in Healthy Volunteers Using T Cell Function Assays in Relation to Whole Blood and Cellular Pharmacokinetics

Autor: Aliede E. in ’t Veld, Manon A. A. Jansen, Bertine W. Huisman, Mascha Schoonakker, Marieke L. de Kam, Dirk Jan A. R. Moes, Mariëtte I. E. van Poelgeest, Jacobus Burggraaf, Matthijs Moerland

Publikováno v: Pharmaceutics, Vol 14, Iss 9, p 1958 (2022)

Therapeutic drug monitoring (TDM) of calcineurin inhibitors (i.e., tacrolimus and cyclosporin A) is standard of care after solid organ transplantation. Although the incidence of acute rejection has strongly decreased, there are still many patients wh

Externí odkaz: https://doaj.org/article/7f17bd0e146741d48b5ea7e1ead8b76b

Erratum to 'Hydroxychloroquine Effects on TLR Signalling: Underexposed but Unneglectable in COVID-19'

Autor: Aliede E. in ‘t Veld, Manon A. A. Jansen, Luuk C. A. Ciere, Matthijs Moerland

Publikováno v: Journal of Immunology Research, Vol 2021 (2021)

Externí odkaz: https://doaj.org/article/29261598611b481aa39b1dc7b7be3608

Immune Monitoring of Mycophenolate Mofetil Activity in Healthy Volunteers Using Ex Vivo T Cell Function Assays

Autor: Moerland, Aliede E. in ’t Veld, Manon A. A. Jansen, Marieke L. de Kam, Yalҫin Yavuz, Dirk Jan A. R. Moes, Kathalijne A. Oudhoff, Mariette I. E. van Poelgeest, Jacobus Burggraaf, Matthijs

Publikováno v: Pharmaceutics; Volume 15; Issue 6; Pages: 1635

Mycophenolate mofetil (MMF) is part of the standard immunosuppressive treatment after transplantation and usually given as “one-dose-fits-all” together with a calcineurin inhibitor (CNI). Although drug concentrations are frequently monitored, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::8444f382573978ab91ff12125a9bf038

Effect of hydroxychloroquine on the cardiac ventricular repolarization: A randomized clinical trial

Autor: Pim Gal, Manon A. A. Jansen, Jørgen K. Kanters, Michiel J. B. Kemme, Aliede E. in ‘t Veld, Michiel J van Esdonk, Matthijs Moerland, Boukje C. Eveleens Maarse, Claus Graff

Publikováno v: Maarse, B C E, Graff, C, Kanters, J K, van Esdonk, M J, Kemme, M J B, 't Veld, A E I, Jansen, M A A, Moerland, M & Gal, P 2022, ' Effect of hydroxychloroquine on the cardiac ventricular repolarization: A randomized clinical trial ', British Journal of Clinical Pharmacology, vol. 88, no. 3, pp. 1054-1062 . https://doi.org/10.1111/bcp.15013, https://doi.org/10.1111/bcp.15013
Eveleens Maarse, B C, Graff, C, Kanters, J K, van Esdonk, M J, Kemme, M J B, in 't Veld, A E, Jansen, M A A, Moerland, M & Gal, P 2022, ' Effect of hydroxychloroquine on the cardiac ventricular repolarization : A randomized clinical trial ', British Journal of Clinical Pharmacology, vol. 88, no. 3, pp. 1054-1062 . https://doi.org/10.1111/bcp.15013
British Journal of Clinical Pharmacology, 88(3), 1054-1062. Wiley-Blackwell
Eveleens Maarse, B C, Graff, C, Kanters, J K, van Esdonk, M J, Kemme, M J B, E in’t Veld, A, Jansen, M A A, Moerland, M & Gal, P 2022, ' Effect of hydroxychloroquine on the cardiac ventricular repolarization : a randomized clinical trial ', British Journal of Clinical Pharmacology, vol. 88, no. 3, pp. 1054-1062 . https://doi.org/10.1111/bcp.15013
British Journal of Clinical Pharmacology

Introduction Hydroxychloroquine has been suggested as possible treatment for Severe Acute Respiratory Syndrome-coronavirus-2 (SARS-CoV-2). Studies reported an increased risk of QTcF-prolongation after treatment with hydroxychloroquine. The aim of thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e16d063e98d603311c2b9e2ad80a1b
https://research.vumc.nl/en/publications/dbe1a844-1e08-4838-aa8d-9bce01bc8d2f