Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alida S.D. Kindt"'
Autor:
Johannes Beckers, Alexandra Aliluev, Sophie Tritschler, Michael Sterr, Alida S.D. Kindt, Malte D Luecken, Anika Böttcher, Julia Hinterdobler, Fabian J. Theis, Lena Oppenländer, Axel Walch, Kerstin Stemmer, Heiko Lickert, Na Sun, Tobias Greisle, Matthias H. Tschöp, Jan Krumsiek, Martin Irmler
Publikováno v:
Nat. Metab. 3, 1202-1216 (2021)
Tritschler, S.
Nature Metabolism
Tritschler, S.
Nature Metabolism
Excess nutrient uptake and altered hormone secretion in the gut contribute to a systemic energy imbalance, which causes obesity and an increased risk of type 2 diabetes and colorectal cancer. This functional maladaptation is thought to emerge at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767abad9568e2eb456aa33e6c7c17403
https://mediatum.ub.tum.de/doc/1639725/document.pdf
https://mediatum.ub.tum.de/doc/1639725/document.pdf
High-Throughput Fractionation Coupled to Mass Spectrometry for Improved Quantitation in Metabolomics
Autor:
Thomas Hankemeier, Tom van der Laan, Alida S.D. Kindt, A. C. Dubbelman, Kevin Duisters, Amy C. Harms
Publikováno v:
Analytical Chemistry
Metabolomics is emerging as an important field in life sciences. However, a weakness of current mass spectrometry (MS) based metabolomics platforms is the time-consuming analysis and the occurrence of severe matrix effects in complex mixtures. To ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e102aaec0703b07138a720691479ccf0
https://pubmed.ncbi.nlm.nih.gov/33054161
https://pubmed.ncbi.nlm.nih.gov/33054161
Autor:
Klaus-Peter Janssen, Marcus Höring, Andrea Christel Machmüller, Andrej Shevchenko, Yuting Wang, Anna Sichler, Sebastian Zeissig, Josef Ecker, Markus Perl, Alida S.D. Kindt, Ralph Burkhardt, Gerhard Liebisch, Jan Krumsiek, Elisa Benedetti, Johannes Plagge
Publikováno v:
Gastroenterology 161, 910-923.e19 (2021)
OBJECTIVE: Lipidomic changes were causally linked to metabolic diseases, but the scenario for colorectal cancer (CRC) is less clear. We investigated the CRC lipidome for putative tumour-specific alterations through analysis of three independent retro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e612c1202eb762aa4ab7d890020312
https://doi.org/10.1053/j.gastro.2021.05.009
https://doi.org/10.1053/j.gastro.2021.05.009
Autor:
Alida S.D. Kindt, Tom van der Laan, Thomas Hankemeier, A. C. Dubbelman, P. Eline Slagboom, Marian Beekman, Cornelia M. van Duijn, Amy C. Harms, Tim Kloots
Publikováno v:
Scientific Reports, 9, 12370. NATURE PUBLISHING GROUP
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports, 9
Scientific Reports, 9:12370. Nature Publishing Group
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports, 9
Scientific Reports, 9:12370. Nature Publishing Group
In the past few years, the gut microbiome has been shown to play an important role in various disorders including in particular cardiovascular diseases. Especially the metabolite trimethylamine-N-oxide (TMAO), which is produced by gut microbial metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04780538aa51af8ff53efdf1ded73d6
https://hdl.handle.net/1887/120378
https://hdl.handle.net/1887/120378
Autor:
Rosalie Morisset, Hongsup Yoon, Jan Krumsiek, Thomas Clavel, Daniela Kolmeder, Claudine Seeliger, Bernhard Kuster, Hannelore Daniel, Dirk Haller, Josef Ecker, Dominic Helm, Alida S.D. Kindt, Sabrina Krautbauer, Sabine Schweizer, Alexander Sigruener, Gabriele Hörmannsperger, Gerhard Liebisch, Alexandra Ganzha, Till Strowig
Publikováno v:
Nature communications
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nat. Commun. 9:3760 (2018)
Nature Communications 9, 3760 (2018). doi:10.1038/s41467-018-05767-4
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nat. Commun. 9:3760 (2018)
Nature Communications 9, 3760 (2018). doi:10.1038/s41467-018-05767-4
Interactions between the gut microbial ecosystem and host lipid homeostasis are highly relevant to host physiology and metabolic diseases. We present a comprehensive multi-omics view of the effect of intestinal microbial colonization on hepatic lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21b953462157ff6e5b5981db85fed5c
https://hdl.handle.net/10033/621546
https://hdl.handle.net/10033/621546
Autor:
Eva-Maria Sedlmeier, Simone Wahl, Jan Knoop, John A. Todd, Alida S.D. Kindt, Ezio Bonifacio, Jan Krumsiek, Rory P. Wilson, Angela Hommel, Michael Laimighofer, Rainer W. Fuerst, Anette-G. Ziegler, Tanja Telieps, Markus Hippich, Maria A. Woerheide
Publikováno v:
J. Autoimmun. 89, 63-74 (2018)
The susceptibility to autoimmune diseases is influenced by genes encoding major histocompatibility complex (MHC) proteins. By examining the epigenetic methylation maps of cord blood samples, we found marked differences in the methylation status of Cp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a745f6e6c97cf6cded3a1da634c1c019
https://doi.org/10.1016/j.jaut.2017.11.008
https://doi.org/10.1016/j.jaut.2017.11.008
Autor:
Kai Wang, Alida S.D. Kindt, Chris Haley, Wenhua Wei, Colin A. Semple, Yunfei Guo, Tony R. Merriman
Publikováno v:
Human Molecular Genetics
Wei, W, Guo, Y, Kindt, A S D, Merriman, T R, Semple, C A, Wang, K & Haley, C S 2014, ' Abundant local interactions in the 4p16.1 region suggest functional mechanisms underlying SLC2A9 associations with human serum uric acid ', Human Molecular Genetics, vol. E-pub 12 May . https://doi.org/10.1093/hmg/ddu227
Wei, W, Guo, Y, Kindt, A S D, Merriman, T R, Semple, C A, Wang, K & Haley, C S 2014, ' Abundant local interactions in the 4p16.1 region suggest functional mechanisms underlying SLC2A9 associations with human serum uric acid ', Human Molecular Genetics, vol. E-pub 12 May . https://doi.org/10.1093/hmg/ddu227
Human serum uric acid concentration (SUA) is a complex trait. A recent meta-analysis of multiple genome-wide association studies (GWAS) identified 28 loci associated with SUA jointly explaining only 7.7% of the SUA variance, with 3.4% explained by tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2eabd5bec8b7c00ee705d6449b9359
https://doi.org/10.1093/hmg/ddu227
https://doi.org/10.1093/hmg/ddu227
Autor:
Ferdinand Stückler, Andreas Beyerlein, Daniela Much, Werner Römisch-Margl, Jerzy Adamski, Sandra Hummel, Cornelia Prehn, Alida S.D. Kindt, Gabi Kastenmüller, Anna Hofelich, Michaela Rossbauer, Susanne Hivner, David Wiesenäcker, Anette-G. Ziegler, Melanie Herbst, Fabian J. Theis, Jan Krumsiek
Publikováno v:
Diabetologia
Lactation for3 months in women with gestational diabetes is associated with a reduced risk of type 2 diabetes that persists for up to 15 years postpartum. However, the underlying mechanisms are unknown. We examined whether in women with gestational d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8e06909090b5c9c08ab91dbbe58fd4
https://pubmed.ncbi.nlm.nih.gov/27423999
https://pubmed.ncbi.nlm.nih.gov/27423999
Publikováno v:
Kindt, A S D, Navarro, P, Semple, C A M & Haley, C S 2013, ' The genomic signature of trait-associated variants ', BMC Genomics, vol. 14, ARTN 108 . https://doi.org/10.1186/1471-2164-14-108
BMC Genomics
BMC Genomics
Background Genome-wide association studies have identified thousands of SNP variants associated with hundreds of phenotypes. For most associations the causal variants and the molecular mechanisms underlying pathogenesis remain unknown. Exploration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d294492d74efe891fa67c734ed4e9ac0
https://hdl.handle.net/20.500.11820/151fc7b8-4cba-44ad-acb8-0d037fc332f2
https://hdl.handle.net/20.500.11820/151fc7b8-4cba-44ad-acb8-0d037fc332f2
Publikováno v:
Genome Biology
Chambers, E V, Kindt, A S & Semple, C A 2011, ' Opening sequence : computational genomics in the era of high-throughput sequencing ', Genome Biology, vol. 12, no. 12, pp. 310 . https://doi.org/10.1186/gb-2011-12-12-310
Chambers, E V, Kindt, A S & Semple, C A 2011, ' Opening sequence : computational genomics in the era of high-throughput sequencing ', Genome Biology, vol. 12, no. 12, pp. 310 . https://doi.org/10.1186/gb-2011-12-12-310
A report on the 11th Cold Spring Harbor Laboratory/Wellcome Trust conference on Genome Informatics, Cold Spring Harbor Laboratories, New York, USA, November 2-5, 2011.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a25e0624c2a8eeca3f08fb30897d86
https://doi.org/10.1186/gb-2011-12-12-310
https://doi.org/10.1186/gb-2011-12-12-310