Výsledky vyhledávání - "Alicja Pogorzelska"

Development and Validation of an RP-HPLC Method for Determination of Atorvastatin and its Hydroxyl Metabolites in Human Plasma

Autor: Alicja Pogorzelska, Marlena Rakicka, Marta Karazniewicz-Lada, Mateusz Malak, Justyna Sznura, Dagmara Sowinska, Justyna Janowska, Patrycja Gorzycka

Publikováno v: Current Pharmaceutical Analysis. 16:238-245

Background: Atorvastatin (AT) belongs to cholesterol-lowering agents, commonly used in patients with an increased risk of cardiovascular disease. The drug, as well as its hydroxyl metabolites, exhibit pharmacological activity, and their plasma levels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b18b7483f44fffd22e7e0b91b77751ba
https://doi.org/10.2174/1573412914666180912110154

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Kinetics of in Vitro Guanine-N7-Alkylation in Calf Thymus DNA by (2S,3S)-1,2-Epoxybutane-3,4-diol 4-methanesulfonate and (2S,3S)-1,2:3,4-Diepoxybutane: Revision of the Mechanism of DNA Cross-Linking by the Prodrug Treosulfan

Autor: Michał Romański, Alicja Pogorzelska, Franciszek K. Główka

Publikováno v: Molecular Pharmaceutics. 16:2708-2718

Prodrug treosulfan, originally registered for treatment of ovarian cancer, has gained a use in conditioning prior to hematopoietic stem cell transplantation. Treosulfan converts nonenzymatically to the monoepoxide intermediate (EBDM), and then to (2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4820e0540eafa497428f5587881633da
https://doi.org/10.1021/acs.molpharmaceut.9b00251

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