A Novel Method for Gene-Specific Enhancement of Protein Translation by Targeting 5'UTRs of Selected Tumor Suppressors.

Autor: Adam Master, Anna Wójcicka, Kamilla Giżewska, Piotr Popławski, Graham R Williams, Alicja Nauman

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0155359 (2016)

BACKGROUND:Translational control is a mechanism of protein synthesis regulation emerging as an important target for new therapeutics. Naturally occurring microRNAs and synthetic small inhibitory RNAs (siRNAs) are the most recognized regulatory molecu

Externí odkaz: https://doaj.org/article/3caf99ec1685417badb2a514860988ec

MiR-224 targets the 3'UTR of type 1 5'-iodothyronine deiodinase possibly contributing to tissue hypothyroidism in renal cancer.

Autor: Joanna Boguslawska, Anna Wojcicka, Agnieszka Piekielko-Witkowska, Adam Master, Alicja Nauman

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24541 (2011)

Type 1 iodothyronine deiodinase (DIO1) catalyses the conversion of prohormone thyroxine to the active thyroid hormone 3,3',5-triiodothyronine (T3), important regulator of cell proliferation and differentiation. DIO1 expression is reduced in the most

Externí odkaz: https://doaj.org/article/d64681f4b52d4f6195243f8034cd3da1

Induction of type 1 iodothyronine deiodinase expression inhibits proliferation and migration of renal cancer cells

Autor: Piotr Popławski, Agnieszka Piekiełko-Witkowska, Katarzyna Rodzik, Theo J. Visser, Beata Rybicka, Alicja Nauman, Joanna Boguslawska

Publikováno v: Molecular and Cellular Endocrinology, 442(C), 58-67. Elsevier Ireland Ltd
Molecular and Cellular Endocrinology, 442, 58-67. Elsevier Ireland Ltd

Type 1 iodothyronine deiodinase (DIO1) regulates peripheral metabolism of thyroid hormones that control cellular proliferation, differentiation and metabolism. The significance of DIO1 in cancer is unknown. In this study we hypothesized that diminish

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5883ea7c193dfde68c8152f2cc382741
https://hdl.handle.net/1765/94888

Regulatory feedback loop between T3 and microRNAs in renal cancer

Autor: Piotr Popławski, Anna Wojcicka, Joanna Boguslawska, Agnieszka Piekiełko-Witkowska, Hanna Kędzierska, Alicja Nauman

Publikováno v: Molecular and Cellular Endocrinology. 384:61-70

microRNAs, short non-coding RNAs, influence key physiological processes, including hormonal regulation, by affecting the expression of genes. In this study we hypothesised that the expression of microRNAs targeting thyroid hormone pathway genes may b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea6cdc27bb8dfde1994378d1fffec90
https://doi.org/10.1016/j.mce.2014.01.006

Untranslated regions of thyroid hormone receptor beta 1 mRNA are impaired in human clear cell renal cell carcinoma

Autor: Piotr Popławski, Veerle Darras, Anna Wojcicka, Graham R. Williams, Agnieszka Piekiełko-Witkowska, Zbigniew Tanski, Joanna Boguslawska, Adam Master, Alicja Nauman

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1802(11):995-1005

Thyroid hormone receptor β1 (TRβ1) is a hormone-dependent transcription factor activated by 3,5,3'- l -triiodothyronine (T3). TRβ1 functions as a tumor suppressor and disturbances of the THRB gene are frequent findings in cancer. Translational con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7063a94da1a93f5364ca9f21f3af92b3