Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alicja Jagiełło"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Cells are known to continuously remodel their local extracellular matrix (ECM) and in a reciprocal way, they can also respond to mechanical and biochemical properties of their fibrous environment. In this study, we measured how stiffness aro
Externí odkaz:
https://doaj.org/article/f69a7b22e8124981ba11a3ac5ba1268a
Publikováno v:
APL Bioengineering, Vol 4, Iss 4, Pp 046105-046105-12 (2020)
The bulk measurement of extracellular matrix (ECM) stiffness is commonly used in mechanobiology. However, past studies by our group show that peri-cellular stiffness is quite heterogeneous and divergent from the bulk. We use optical tweezers active m
Externí odkaz:
https://doaj.org/article/bc1ca05a868c4a9d8f6c402a2331a3c1
Autor:
Michael F. Olson, Paul Timpson, Marina Pajic, Claire Vennin, Gillian Mackay, David Sumpton, Jurre J. Kamphorst, Evdokia Michalopoulou, Mathieu Unbekandt, Lynn McGarry, Nikolaj Gadegaard, Alicja Jagiełło, Marie Francene Cutiongco, June Munro, Nicola Rath
The high mortality of pancreatic cancer demands that new therapeutic avenues be developed. The orally available small-molecule inhibitor AT13148 potently inhibits ROCK1 and ROCK2 kinases that regulate the actomyosin cytoskeleton. We previously report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06694ff8940566fb5d0a2d2bd7b2e376
https://doi.org/10.1158/0008-5472.c.6509924.v1
https://doi.org/10.1158/0008-5472.c.6509924.v1
Autor:
Michael F. Olson, Paul Timpson, Marina Pajic, Claire Vennin, Gillian Mackay, David Sumpton, Jurre J. Kamphorst, Evdokia Michalopoulou, Mathieu Unbekandt, Lynn McGarry, Nikolaj Gadegaard, Alicja Jagiełło, Marie Francene Cutiongco, June Munro, Nicola Rath
Supplemental Figure S1. No effect of ROCK inhibitors on the expression of ROCK1 or ROCK2. Supplemental Figure S2. ROCK1 and ROCK2 knockdown, dose-response relationships and IC50 determinations for AT13148 on cell morphology parameters. Supplemental F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8578b2161060ee356a2dff3e65950193
https://doi.org/10.1158/0008-5472.22417742.v1
https://doi.org/10.1158/0008-5472.22417742.v1
Publikováno v:
Acta Biomater
Cells are known to constantly interact with their local extracellular matrix (ECM) and respond to a variety of biochemical and mechanical cues received from the ECM. Nonetheless, comprehensive understanding of cell-ECM interactions has been elusive.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cfb4522c8b867c3484ff1a54a0d4a8
https://escholarship.org/uc/item/5gz1q7db
https://escholarship.org/uc/item/5gz1q7db
Cells are known to continuously remodel their local extracellular matrix (ECM) and in a reciprocal way, they can also respond to mechanical and biochemical properties of their fibrous environment. In this study, we measured how stiffness around derma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dfd1b1e14b2dd19df996c241dc5c773
https://doi.org/10.21203/rs.3.rs-1348112/v1
https://doi.org/10.21203/rs.3.rs-1348112/v1
Publikováno v:
Optical Trapping and Optical Micromanipulation XVIII.
Studies of cell-extracellular matrix (ECM) interactions within fibrous systems such as collagen or fibrin are challenging, particularly if peri-cellular stiffness cannot be monitored. Here we present our light-based method for non-invasive patterning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09fe98cc0ea6177e7c8665239d74cbba
https://doi.org/10.1117/12.2595590
https://doi.org/10.1117/12.2595590
Autor:
Victor K. Lai, Mark Keating, Robert T. Tranquillo, Alicja Jagiełło, Billianne Schultz, Connie M. Wang, Greeshma Thrivikraman, Alexander Nelson, Sandra Johnson, Alex J. Levine, Elliot L. Botvinick
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 29
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 29
Despite the ubiquitous importance of cell contact guidance, the signal-inducing contact guidance of mammalian cells in an aligned fibril network has defied elucidation. This is due to multiple interdependent signals that an aligned fibril network pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9225334eeceb3b221307235d1a7ae2
https://pubmed.ncbi.nlm.nih.gov/34266950
https://pubmed.ncbi.nlm.nih.gov/34266950
Publikováno v:
SSRN Electronic Journal.
Cells are known to constantly interact with their local extracellular matrix (ECM) and respond to a variety of biochemical and mechanical cues received from the ECM. Nonetheless, comprehensive understanding of cell-ECM interactions has been elusive.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98e3b35fd5c08076c79fed8e38b8a8c4
https://doi.org/10.2139/ssrn.3919718
https://doi.org/10.2139/ssrn.3919718
Publikováno v:
APL bioengineering, vol 4, iss 4
APL Bioengineering, Vol 4, Iss 4, Pp 046105-046105-12 (2020)
APL Bioengineering
APL Bioengineering, Vol 4, Iss 4, Pp 046105-046105-12 (2020)
APL Bioengineering
The bulk measurement of extracellular matrix (ECM) stiffness is commonly used in mechanobiology. However, past studies by our group show that peri-cellular stiffness is quite heterogeneous and divergent from the bulk. We use optical tweezers active m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7311bc9e6eac9bc0d6229a23a6b0a398
https://escholarship.org/uc/item/6nq6j0h1
https://escholarship.org/uc/item/6nq6j0h1