Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Alicja Bielawska"'
Autor:
Tess V. Dupre, Mark A. Doll, Parag P. Shah, Cierra N. Sharp, Deanna Siow, Judit Megyesi, James Shayman, Alicja Bielawska, Jacek Bielawski, Levi J. Beverly, Maria Hernandez-Corbacho, Christopher J. Clarke, Ashley J. Snider, Rick G. Schnellmann, Lina M. Obeid, Yusuf A. Hannun, Leah J. Siskind
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 7, Pp 1439-1452 (2017)
Acute kidney injury (AKI), resulting from chemotherapeutic agents such as cisplatin, remains an obstacle in the treatment of cancer. Cisplatin-induced AKI involves apoptotic and necrotic cell death, pathways regulated by sphingolipids such as ceramid
Externí odkaz:
https://doaj.org/article/e435c62e69a34d97a8074be1dae00b36
Autor:
Maria Podbielska, Zdzisław M. Szulc, Ewa Kurowska, Edward L. Hogan, Jacek Bielawski, Alicja Bielawska, Narayan R. Bhat
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 11, Pp 2028-2039 (2016)
Th1 pro-inflammatory cytokines, i.e., TNF-α and IFN-γ, in combination are known to induce cell death in several cell types, including oligodendrocytes, but the mechanism of their synergistic cytotoxicity is unclear. Although ceramide (Cer) has been
Externí odkaz:
https://doaj.org/article/0cb7825e57444a58a6b77d7b412c5112
Autor:
Aiping Bai, Cungui Mao, Russell W Jenkins, Zdzislaw M Szulc, Alicja Bielawska, Yusuf A Hannun
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0177805 (2017)
Acid ceramidase, which catalyzes ceramide hydrolysis to sphingosine and free fatty acid mainly in the lysosome, is being recognized as a potential therapeutic target for cancer. B13 is an effective and selective acid ceramidase inhibitor in vitro, bu
Externí odkaz:
https://doaj.org/article/3ce94aae187747b5aa33eeef1dbeb586
Autor:
Dhirendra K. Simanshu, Xiuhong Zhai, David Munch, Daniel Hofius, Jonathan E. Markham, Jacek Bielawski, Alicja Bielawska, Lucy Malinina, Julian G. Molotkovsky, John W. Mundy, Dinshaw J. Patel, Rhoderick E. Brown
Publikováno v:
Cell Reports, Vol 6, Iss 2, Pp 388-399 (2014)
The accelerated cell death 11 (acd11) mutant of Arabidopsis provides a genetic model for studying immune response activation and localized cellular suicide that halt pathogen spread during infection in plants. Here, we elucidate ACD11 structure and f
Externí odkaz:
https://doaj.org/article/d44452172639457987ee1386b90c25cd
Autor:
Qi Hou, Junfei Jin, Hui Zhou, Sergei A. Novgorodov, Alicja Bielawska, Zdzislaw M. Szulc, Yusuf A. Hannun, Lina M. Obeid, Yi-Te Hsu
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 2, Pp 278-288 (2011)
C6-pyridinium (d-erythro-2-N-[6′-(1′′-pyridinium)-hexanoyl]sphingosine bromide [LCL29]) is a cationic mitochondrion-targeting ceramide analog that promotes mitochondrial permeabilization and cancer cell death. In this study, we compared the bio
Externí odkaz:
https://doaj.org/article/273e6d08020446feb5a1621d0a08299c
Autor:
Samar M. Hammad, Jason S. Pierce, Farzan Soodavar, Kent J. Smith, Mohammed M. Al Gadban, Barbara Rembiesa, Richard L. Klein, Yusuf A. Hannun, Jacek Bielawski, Alicja Bielawska
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 10, Pp 3074-3087 (2010)
We used a HPLC-MS/MS methodology for determination of a basic metabolomic profile (18:1,18:0 sphingoid backbone, C14-C26 N-acyl part) of “normal” sphingolipid levels in human serum and plasma. Blood was collected from healthy males and nonpregnan
Externí odkaz:
https://doaj.org/article/de6c5cacb1814381a7e3d6fb199fa18b
Autor:
Junfei Jin, Thomas D. Mullen, Qi Hou, Jacek Bielawski, Alicja Bielawska, Xiaoming Zhang, Lina M. Obeid, Yusuf A. Hannun, Yi-Te Hsu
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 12, Pp 2389-2397 (2009)
Compound C is commonly used as an inhibitor of AMP-activated protein kinase (AMPK), which serves as a key energy sensor in cells. In this study, we found that Compound C treatment of MCF7 cells led to Bax redistribution from the cytoplasm to mitochon
Externí odkaz:
https://doaj.org/article/1196f9908bd143d1a874528e684a4431
Autor:
Dayanjan S. Wijesinghe, Preeti Subramanian, Nadia F. Lamour, Luciana B. Gentile, Maria H. Granado, Alicja Bielawska, Zdzislaw Szulc, Antonio Gomez-Munoz, Charles E. Chalfant
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 10, Pp 1986-1995 (2009)
Previously, our laboratory demonstrated that ceramide-1-phosphate (C1P) specifically activated group IVA cytosolic phospholipase A2 (cPLA2α) in vitro. In this study, we investigated the chain length specificity of this interaction. C1P with an acyl-
Externí odkaz:
https://doaj.org/article/315344b2f54847118d525a14b61a70f0
Autor:
Dayanjan S. Wijesinghe, Autumn Massiello, Preeti Subramanian, Zdzislaw Szulc, Alicja Bielawska, Charles E. Chalfant
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 12, Pp 2706-2716 (2005)
Previous studies in our laboratory have established ceramide kinase (CERK) as a critical mediator of eicosanoid synthesis. To date, CERK has not been well characterized in vitro. In this study, we investigated the substrate specificity of CERK using
Externí odkaz:
https://doaj.org/article/d6c22a85dd3e46a99e95dc5fced6a1bb
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 3, Pp 496-506 (2004)
The protein phosphatases1 (PP1) and 2A (PP2A) serve as ceramide-activated protein phosphatases (CAPP). In this study, the structural requirements for interaction between ceramide and CAPP were determined. d-erythro-C6 ceramide activated the catalytic
Externí odkaz:
https://doaj.org/article/a6aa04bdad2846efa906c980b63ec96c