Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Alicja, Czopek"'
Autor:
Dan Pugh, Dilip Patel, Gillian Macnaught, Alicja Czopek, Lorraine Bruce, James Donachie, Peter J. Gallacher, Sovira Tan, Mark Ahlman, Peter C. Grayson, Neil Basu, Neeraj Dhaun
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Disease-monitoring in large vessel vasculitis (LVV) is challenging. Simultaneous 18F-fluorodeoxyglucose positron emission tomography with magnetic resonance imaging (PET/MRI) provides functional assessment of vascular inflammation alongside
Externí odkaz:
https://doaj.org/article/0587b6ed27044667908bb2fb3ec350f6
Autor:
Josselin Nespoux, Marie-Louise T. Monaghan, Natalie K. Jones, Kevin Stewart, Laura Denby, Alicja Czopek, John J. Mullins, Robert I. Menzies, Andrew H. Baker, Matthew A. Bailey
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract P2X7 receptors mediate immune and endothelial cell responses to extracellular ATP. Acute pharmacological blockade increases renal blood flow and filtration rate, suggesting that receptor activation promotes tonic vasoconstriction. P2X7 expre
Externí odkaz:
https://doaj.org/article/3754b0ae722445b28dc0fc7b7de55dfa
Autor:
Kathleen M. Scullion, A. D. Bastiaan Vliegenthart, Laura Rivoli, Wilna Oosthuyzen, Tariq E. Farrah, Alicja Czopek, David J. Webb, Robert W. Hunter, Matthew A. Bailey, Neeraj Dhaun, James W. Dear
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101937- (2021)
Summary: Vascular and kidney dysfunction commonly co-exist. There is a need for biomarkers of vascular health. Circulating microRNAs are biomarkers; miR-126 is endothelial cell-enriched. We measured circulating miR-126 in rats with nephrotoxic nephri
Externí odkaz:
https://doaj.org/article/be8bdfd2958a4679a313fe5958f85e1c
Autor:
Tariq E. Farrah, Vanessa Melville, Alicja Czopek, Henry Fok, Lorraine Bruce, Nicholas L. Mills, Matthew A. Bailey, David J. Webb, James W. Dear, Neeraj Dhaun
Publikováno v:
Farrah, T E, Melville, V, Czopek, A, Fok, H, Bruce, L, Mills, N L, Bailey, M A, Webb, D J, Dear, J W & Dhaun, N 2022, ' Arterial stiffness, endothelial dysfunction and impaired fibrinolysis are pathogenic mechanisms contributing to cardiovascular risk in ANCA-associated vasculitis ', Kidney International, vol. 102, pp. 1115-1126 . https://doi.org/10.1016/j.kint.2022.07.026
Cardiovascular disease is a complication of systemic inflammatory diseases and anti-neutrophil cytoplasm antibody-associated vasculitis (AAV) is an exemplar. Mechanisms are poorly understood, and risk-reduction strategies are lacking.In a series of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bc4d0f1946160ae0e9cb000e38e96c
https://doi.org/10.1016/j.kint.2022.07.026
https://doi.org/10.1016/j.kint.2022.07.026
Autor:
Alicja Czopek, Rebecca Moorhouse, Peter J. Gallacher, Dan Pugh, Jessica R. Ivy, Tariq E. Farrah, Emily Godden, Robert W. Hunter, David J. Webb, Pierre-Louis Tharaux, David C. Kluth, James W. Dear, Matthew A. Bailey, Neeraj Dhaun
Publikováno v:
Science Translational Medicine. 14
Acute kidney injury (AKI) is common and associated with increased risks of cardiovascular and chronic kidney disease. Causative molecular/physiological pathways are poorly defined. There are no therapies to improve long-term outcomes. An activated en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d882a90c1447e70db1e2cae1b1d1ea
https://doi.org/10.1126/scitranslmed.abf5074
https://doi.org/10.1126/scitranslmed.abf5074
Autor:
Josselin Nespoux, Marie‐Louise T. Monaghan, Natalie K. Jones, Laura Denby, Alicja Czopek, John J. Mullins, Robert I. Menzies, Andrew H. Baker, Matthew A. Bailey
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cd0ea0069a728e33485d2a4b86a4a5e
https://doi.org/10.1096/fasebj.2022.36.s1.r5740
https://doi.org/10.1096/fasebj.2022.36.s1.r5740
Autor:
Hannah M Costello, Georgios Krilis, Celine Grenier, David Severs, Alicja Czopek, Jessica R Ivy, Mark Nixon, Megan C Holmes, Dawn E W Livingstone, Ewout J Hoorn, Neeraj Dhaun, Matthew A Bailey
Publikováno v:
Costello, H, Krilis, G, Grenier, C, Severs, D, Czopek, A, Ivy, J R, Nixon, M, Holmes, M C, Livingstone, D E W, Hoorn, E J, Dhaun, N & Bailey, M A 2022, ' High salt intake activates the hypothalamic-pituitary-adrenal axis, amplifies the stress response, and alters tissue glucocorticoid exposure in mice ', Cardiovascular Research . https://doi.org/10.1093/cvr/cvac160
Aims High salt intake is common and contributes to poor cardiovascular health. Urinary sodium excretion correlates directly with glucocorticoid excretion in humans and experimental animals. We hypothesized that high salt intake activates the hypothal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96df43a514d5a254e7661b3ca6a200a1
https://pubmed.ncbi.nlm.nih.gov/36368681
https://pubmed.ncbi.nlm.nih.gov/36368681
Autor:
Dawn E W Livingstone, John J. Mullins, Kevin Stewart, John Wiseman, James W. Dear, Carmel M. Moran, Bryan R. Conway, Patrick W. F. Hadoke, Laura Denby, Robert I. Menzies, Matthew A. Bailey, Natalie K. Jones, David J. Webb, Alicja Czopek, Adrian Thomson, Carolynn Cairns, Neeraj Dhaun
Publikováno v:
Jones, N, Stewart, K, Czopek, A, Menzies, R, Thomson, A W, Moran, C, Cairns, C, Conway, B, Denby, L, Livingstone, D, Wiseman, J, Hadoke, P, Webb, D, Dhaun, N, Dear, J, Mullins, J & Bailey, M 2020, ' Endothelin-1 mediates the systemic and renal hemodynamic effects of GPR81 activation ', Hypertension . https://doi.org/10.1161/HYPERTENSIONAHA.119.14308
Hypertension (Dallas, Tex. : 1979)
Hypertension (Dallas, Tex. : 1979)
Supplemental Digital Content is available in the text.
GPR81 (G-protein-coupled receptor 81) is highly expressed in adipocytes, and activation by the endogenous ligand lactate inhibits lipolysis. GPR81 is also expressed in the heart, liver, and
GPR81 (G-protein-coupled receptor 81) is highly expressed in adipocytes, and activation by the endogenous ligand lactate inhibits lipolysis. GPR81 is also expressed in the heart, liver, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db93e9f8bfa30f8527af2997cc8ba983
https://doi.org/10.1161/hypertensionaha.119.14308
https://doi.org/10.1161/hypertensionaha.119.14308
Autor:
K. M. Scullion, Wilna Oosthuyzen, A. D. B. Vliegenthart, Robert W. Hunter, Tariq E. Farrah, Alicja Czopek, Matthew A. Bailey, Neeraj Dhaun, James W. Dear, David J. Webb, Laura Rivoli
BackgroundVascular and kidney dysfunction commonly co-exist. There is an unmet need for biomarkers of vascular health. Circulating microRNAs (miRs) are disease biomarkers; miR-126 is endothelial cell-enriched. We measured circulating miR-126 in rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05b62be418afb58f7c724c190383996
Publikováno v:
Heart Journal - SCF.
Introduction Hypertension is a major risk factor for cardiovascular and chronic kidney disease. However, its causes remains unclear in most cases. Our recent data suggests that macrophages contribute to, and protect from, hypertension by regulating t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d47c42e92aae2222ccd710457d6edd5
https://doi.org/10.1136/heartjnl-2020-scf.17
https://doi.org/10.1136/heartjnl-2020-scf.17