Výsledky vyhledávání - "Alicia Y. Volmar"

Mechanisms of isoform-specific residue influence on GTP-bound HRas, KRas, and NRas

Autor: Alicia Y. Volmar, Hugo Guterres, Hao Zhou, Derion Reid, Spiro Pavlopoulos, Lee Makowski, Carla Mattos

Publikováno v: Biophysical Journal. 121:3616-3629

HRas, KRas, and NRas are GTPases with a common set of effectors that control many cell-signaling pathways, including proliferation through Raf kinase. Their G-domains are nearly identical in sequence, with a few isoform-specific residues that have an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385b811dc63d029bde5753a7a92ea68d
https://doi.org/10.1016/j.bpj.2022.07.005

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Titration of ionizable groups in proteins using multiple neutron data sets from a single crystal: application to the small GTPase Ras

Autor: Carla Mattos, Flora Meilleur, Alicia Y. Volmar, Ryan Knihtila

Publikováno v: Acta Crystallogr F Struct Biol Commun

Neutron protein crystallography (NPC) reveals the three-dimensional structures of proteins, including the positions of H atoms. The technique is particularly suited to elucidate ambiguous catalytic steps in complex biochemical reactions. While NPC un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5bd41db4db06eb235239aedfcce39b
https://doi.org/10.1107/s2053230x18018125

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Ras Structure, Dynamics and Conformational States Assessed by MD Simulations and Solution Wide angle X‐ray Scattering

Autor: Hao Zhou, Hugo Guterres, Alicia Y. Volmar, Lee Makowski, Carla Mattos

Publikováno v: The FASEB Journal. 34:1-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::977f0fc8ea84b8d1466ce6468286a7c5
https://doi.org/10.1096/fasebj.2020.34.s1.03160

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Interaction between Ras and the two Ras‐Binding Domains of Raf kinase

Autor: Trinity Cookis, Alicia Y. Volmar, Carla Mattos, Kathleen Merritt

Publikováno v: The FASEB Journal. 34:1-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89dbf3ff1ba181f6ab69fdfd248dbb21
https://doi.org/10.1096/fasebj.2020.34.s1.02405

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K-Ras Populates Conformational States Differently from Its Isoform H-Ras and Oncogenic Mutant K-RasG12D

Autor: Jillian A. Parker, Carla Mattos, Spiro Pavlopoulos, Alicia Y. Volmar

Publikováno v: Structure. 26:810-820.e4

Summary Structures of wild-type K-Ras from crystals obtained in the presence of guanosine triphosphate (GTP) or its analogs have remained elusive. Of the K-Ras mutants, only K-RasG12D and K-RasQ61H are available in the PDB representing the activated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31566d5592e8b4cd0fbd927a1c2adda
https://doi.org/10.1016/j.str.2018.03.018

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