Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Alicia Wong"'
Autor:
Seokwon Jo, Samantha Pritchard, Alicia Wong, Nandini Avula, Ahmad Essawy, John Hanover, Emilyn U. Alejandro
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Protein O-GlcNAcylation is a nutrient and stress-sensitive protein post-translational modification (PTM). The addition of an O-GlcNAc molecule to proteins is catalyzed by O-GlcNAc transferase (OGT), whereas O-GlcNAcase (OGA) enzyme is responsible for
Externí odkaz:
https://doaj.org/article/c526a5a84dea408e9ce3e1b64026f57d
Autor:
Elise Y. Cai, Jose Garcia, Yuzhen Liu, Funda Vakar-Lopez, Sonali Arora, Holly M. Nguyen, Bryce Lakely, Lisha Brown, Alicia Wong, Bruce Montgomery, John K. Lee, Eva Corey, Jonathan L. Wright, Andrew C. Hsieh, Hung-Ming Lam
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Bladder cancer is among the most prevalent cancers worldwide. Currently, few bladder cancer models have undergone thorough characterization to assess their fidelity to patient tumors, especially upon propagation in the laboratory. Here, we e
Externí odkaz:
https://doaj.org/article/5b9f2e7e7f544668b01d526be6457f1a
Autor:
Chiara Ghezzi, Alicia Wong, Bao Ying Chen, Bernard Ribalet, Robert Damoiseaux, Peter M. Clark
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Many cancer cells have increased glucose consumption compared to normal cells, a feature that can be exploited therapeutically. Here, the authors carry out a chemical screen and identify compounds that selectively blocks glucose metabolism in non-sma
Externí odkaz:
https://doaj.org/article/2eda619824de42219eeab1b51ef3beb0
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 105 (2022)
Previously we utilized a murine model to demonstrate that Ogt deletion in pancreatic progenitors (OgtKOPanc) causes pancreatic hypoplasia, partly mediated by a reduction in the Pdx1-expressing pancreatic progenitor pool. Here, we continue to explore
Externí odkaz:
https://doaj.org/article/2879a5dc9b28497b9939db1a83c03487
Autor:
Rosette N. Tamaddondoust, Alicia Wong, Megha Chandrashekhar, Edouard I. Azzam, Tommy Alain, Yi Wang
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8774 (2022)
The biological impact of ionizing radiation (IR) on humans depends not only on the physical properties and absorbed dose of radiation but also on the unique susceptibility of the exposed individual. A critical target of IR is DNA, and the DNA damage
Externí odkaz:
https://doaj.org/article/01178547a1e546bda2cdb5a6a8fcb9a1
Autor:
Brian Akhaphong, Daniel C. Baumann, Megan Beetch, Amber D. Lockridge, Seokwon Jo, Alicia Wong, Tate Zemanovic, Ramkumar Mohan, Danica L. Fondevilla, Michelle Sia, Maria Ruth B. Pineda-Cortel, Emilyn U. Alejandro
Publikováno v:
JCI Insight, Vol 6, Iss 13 (2021)
Fetal growth restriction, or low birth weight, is a strong determinant for eventual obesity and type 2 diabetes. Clinical studies suggest placental mechanistic target of rapamycin (mTOR) signaling regulates fetal birth weight and the metabolic health
Externí odkaz:
https://doaj.org/article/2188b8bb4a594bf4ac7526c1cf4a3c92
Autor:
Jing Song, Anja Schwenzer, Alicia Wong, Sara Turcinov, Cliff Rims, Lorena Rodriguez Martinez, David Arribas-Layton, Christina Gerstner, Virginia S. Muir, Kim S. Midwood, Vivianne Malmström, Eddie A. James, Jane H. Buckner
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Tenascin-C (TNC), an extracellular matrix protein that has proinflammatory properties, is a recently described antibody target in rheumatoid arthritis (RA). In this study, we utilized a systematic discovery process and identified 5 potentially novel
Externí odkaz:
https://doaj.org/article/817bed96baa04ee0b9d77c2c5b9df132
Publikováno v:
Biology, Vol 11, Iss 3, p 347 (2022)
Acute pancreatitis (AP) involves premature trypsinogen activation, which mediates a cascade of pro-inflammatory signaling that causes early stages of pancreatic injury. Activation of the transcription factor κB (NF-κB) and secretion of pro-inflamma
Externí odkaz:
https://doaj.org/article/2788f7740e45478f86717dfd0d817d49
Autor:
Katarina Hočevar, Matej Vizovišek, Alicia Wong, Joanna Kozieł, Marko Fonović, Barbara Potempa, Richard J. Lamont, Jan Potempa, Boris Turk
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Porphyromonas gingivalis, the main etiologic agent of periodontitis, secretes cysteine proteases named gingipains. HRgpA and RgpB gingipains have Arg-specificity, while Kgp gingipain is Lys-specific. Together they can cleave an array of proteins and
Externí odkaz:
https://doaj.org/article/b5f84353b5654e30925e7e9b2cbb8b13
Publikováno v:
Cells, Vol 10, Iss 1, p 93 (2021)
Insulin-secreting pancreatic β-cells express proteins characteristic of D-serine regulated synapses, but the acute effect of D-serine co-agonism on its presumptive β-cell target, N-methyl D-aspartate receptors (NMDARs), is unclear. We used multiple
Externí odkaz:
https://doaj.org/article/c26fbd05da9344e39d9295cb18b2a4e1