Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alicia V. Zamudio"'
Autor:
Arup K. Chakraborty, John Mantiega, Anthony A. Hyman, Ann Boija, Mrityunjoy Kar, Patrick M. McCall, Jesse M. Platt, Charles H. Li, Mengyang Fan, Victoria E. Clark, Tong Lee, Alessandra Dall’Agnese, Jonathan E. Henninger, Krishna Shrinivas, Ido Sagi, Phillip A. Sharp, Dylan J. Taatjes, Tim-Michael Decker, Tinghu Zhang, Jing-Ke Weng, Eliot L. Coffey, Lena K. Afeyan, Alicia V. Zamudio, Nathanael S. Gray, Benjamin R. Sabari, Isaac A. Klein, Richard A. Young, Nancy M. Hannett, Young-Tae Chang, Ozgur Oksuz, Yang Guo, Susana Wilson Hawken
Publikováno v:
Cancer Research. 81:GS3-10
The molecules of the cell are compartmentalized into membrane- and non-membrane-bound organelles. Many non-membrane-bound organelles are phase-separated biomolecular condensates with distinct physicochemical properties that can absorb and concentrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::813421c57b00b902403b00605df75237
https://doi.org/10.1158/1538-7445.sabcs20-gs3-10
https://doi.org/10.1158/1538-7445.sabcs20-gs3-10
Autor:
Xin Tang, Gary LeRoy, Alicia V. Zamudio, Alessandra Dall’Agnese, Richard A. Young, Emile Wogram, Jurian Schuijers, Nancy M. Hannett, Jonathan E. Henninger, Tenzin Lungjangwa, Tong Ihn Lee, Jesse M. Platt, Eliot L. Coffey, Ozgur Oksuz, X. Shawn Liu, Styliani Markoulaki, Charles H. Li, Lena K. Afeyan, Rudolf Jaenisch, Devon S. Svoboda
Publikováno v:
Nature
Methyl CpG binding protein 2 (MeCP2) is a key component of constitutive heterochromatin, which is crucial for chromosome maintenance and transcriptional silencing1–3. Mutations in the MECP2 gene cause the progressive neurodevelopmental disorder Ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f51fc72bdd6c60ff1b8c95fcbf6cd08
https://doi.org/10.1038/s41586-020-2574-4
https://doi.org/10.1038/s41586-020-2574-4
Autor:
Yang Eric Guo, Brian J. Abraham, Tim-Michael Decker, Dylan J. Taatjes, Jenna K. Rimel, Phillip A. Sharp, Tong Ihn Lee, Charli B. Fant, John C. Manteiga, Krishna Shrinivas, Lena K. Afeyan, Benjamin R. Sabari, Richard A. Young, Jan-Hendrik Spille, Jonathan E. Henninger, Alessandra Dall’Agnese, Alicia V. Zamudio, Nancy M. Hannett, Ann Boija, Ibrahim I Cisse
Publikováno v:
Nature
The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a transcription initiation complex, and a transition to an elongation complex1–4. The large subunit of Pol II contains an intrinsically disordered C-terminal domain t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd05b7c69848ab64e299895bb7068c6d
https://doi.org/10.1038/s41586-019-1464-0
https://doi.org/10.1038/s41586-019-1464-0
Autor:
Tong Ihn Lee, Richard A. Young, Ido Sagi, Gary LeRoy, Charalampos Lazaris, Ming M. Zheng, Ozgur Oksuz, Arup K. Chakraborty, Phillip A. Sharp, Alicia V. Zamudio, Nancy M. Hannett, J Owen Andrews, Jonathan E. Henninger, Krishna Shrinivas, Ibrahim I Cisse
Publikováno v:
Cell
Regulation of biological processes typically incorporate mechanisms that both initiate and terminate the process and, where understood, these mechanisms often involve feedback control. Regulation of transcription is a fundamental cellular process whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d3675667c766e0f4b36975eab909000
https://pubmed.ncbi.nlm.nih.gov/33333019
https://pubmed.ncbi.nlm.nih.gov/33333019
Autor:
John C. Manteiga, Diana M. Mitrea, Oliver Beutel, Benjamin Levin, Alicia V. Zamudio, Avinash Patel, Matthäus Mittasch, Beatriz Ferreira Gomes
Publikováno v:
Fluorescent Probes ISBN: 9780128235157
Biomolecular condensates are membrane-less cellular compartments that form via phase separation. They serve a multitude of functions in all types of cells. Important insights into the composition, architecture and dynamics of biomolecular condensates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14b68cdb58cbe085fbe697e550c0a2e3
https://doi.org/10.1016/bs.mim.2020.11.005
https://doi.org/10.1016/bs.mim.2020.11.005
Autor:
Arup K. Chakraborty, Jesse M. Platt, Ozgur Oksuz, Tim-Michael Decker, Nathanael S. Gray, Richard A. Young, Yang Eric Guo, Jonathan E. Henninger, John C. Manteiga, Mengyang Fan, Patrick M. McCall, Alicia V. Zamudio, Eliot L. Coffey, Alessandra Dall’Agnese, Phillip A. Sharp, Lena K. Afeyan, Isaac A. Klein, Nancy M. Hannett, Krishna Shrinivas, Victoria E. Clark, Benjamin R. Sabari, Ann Boija, Mrityunjoy Kar, Charles H. Li, Anthony A. Hyman, Dylan J. Taatjes, Jing-Ke Weng, Susana Wilson Hawken, Ido Sagi, Tinghu Zhang, Young-Tae Chang, Tong Ihn Lee
Publikováno v:
Science
PMC
PMC
Drug partitioning in nuclear condensates There is increasing interest in the function of phase-separated biomolecular condensates in cells because of their distinct properties and expanding roles in important biological processes. Klein et al. consid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58dbfd9ca343e2e0aae160b9eb4e7eba
https://europepmc.org/articles/PMC7735713/
https://europepmc.org/articles/PMC7735713/
Autor:
Richard A. Young, John C. Manteiga, Jurian Schuijers, Tong Ihn Lee, Daniel S. Day, Alicia V. Zamudio, Denes Hnisz, Abraham S. Weintraub
Publikováno v:
Elsevier
Cell Reports, Vol 23, Iss 2, Pp 349-360 (2018)
Cell reports
Cell Reports
Cell Reports, Vol 23, Iss 2, Pp 349-360 (2018)
Cell reports
Cell Reports
Transcriptional dysregulation of the MYC oncogene is among the most frequent events in aggressive tumor cells, and this is generally accomplished by acquisition of a super-enhancer somewhere within the 2.8 Mb TAD where MYC resides. We find that these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857b631454618044d4f4b3881d28e1f9
https://doi.org/10.1016/j.celrep.2018.03.056
https://doi.org/10.1016/j.celrep.2018.03.056
Autor:
Brian J. Abraham, Benjamin R. Sabari, Alicia V. Zamudio, Dylan J. Taatjes, Nancy M. Hannett, Jonathan E. Henninger, Tim-Michael Decker, Ozgur Oksuz, Ann Boija, Ibrahim I Cisse, Eliot L. Coffey, Susana Wilson Hawken, Isaac A. Klein, Tong I. Lee, Jan-Hendrik Spille, Lena K. Afeyan, Charles H. Li, Alessandra Dall’Agnese, John C. Manteiga, Richard A. Young, Jurian Schuijers
Publikováno v:
Mol Cell
PMC
PMC
The gene expression programs that define the identity of each cell are controlled by master transcription factors (TFs) that bind cell-type-specific enhancers, as well as signaling factors, which bring extracellular stimuli to these enhancers. Recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7185548d26f43e122d2f61bcdefc827
https://pubmed.ncbi.nlm.nih.gov/31563432
https://pubmed.ncbi.nlm.nih.gov/31563432
Autor:
Richard A. Young, Phillip A. Sharp, Eliot L. Coffey, Jurian Schuijers, Isaac A. Klein, Benjamin R. Sabari, Arup K. Chakraborty, Alicia V. Zamudio, Ann Boija, Nancy M. Hannett, Krishna Shrinivas
Publikováno v:
PMC
Mol Cell
Mol Cell
© 2019 Elsevier Inc. Enhancers are DNA elements that are bound by transcription factors (TFs), which recruit coactivators and the transcriptional machinery to genes. Phase-separated condensates of TFs and coactivators have been implicated in assembl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8498dcf46632b98a3f16d366e54b9074
https://doi.org/10.1101/495606
https://doi.org/10.1101/495606
Autor:
Alicia V. Zamudio, Paras S. Minhas, Li-Huei Tsai, Fan Gao, Peng Jin, Elizabeta Gjoneska, Jia Meng, Feiran Zhang, Yuan-Ta Lin, Jemmie Cheng, Alexi Nott, Tak Ko
Publikováno v:
Nature neuroscience
Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). The RTT missense MECP2R306C mutation prevents MeCP2 from interacting with the NCoR/histone deacetylase 3 (HDAC3) complex; however, the neuronal function of HDAC3 is incompl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05f4398313aa566f28acbcde3f26fe0
https://doi.org/10.1038/nn.4347
https://doi.org/10.1038/nn.4347