Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alicia Steffens"'
Autor:
Tyler J. Alban, Matthew M. Grabowski, Balint Otvos, Defne Bayik, Wesley Wang, Ajay Zalavadia, Vlad Makarov, Katie Troike, Mary McGraw, Anja Rabljenovic, Adam Lauko, Chase Neumann, Gustavo Roversi, Kristin A. Waite, Gino Cioffi, Nirav Patil, Thuy T. Tran, Kathleen McCortney, Alicia Steffens, C. Marcela Diaz, J. Mark Brown, Kathleen M. Egan, Craig M. Horbinski, Jill S. Barnholtz-Sloan, Prajwal Rajappa, Michael A. Vogelbaum, Richard Bucala, Timothy A. Chan, Manmeet S. Ahluwalia, Justin D. Lathia
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Intratumoral heterogeneity is a defining hallmark of glioblastoma, driving drug resistance and ultimately recurrence. Many somatic drivers of microenvironmental change have been shown to affect this heterogeneity and, ultimately, the treatment respon
Externí odkaz:
https://doaj.org/article/235cfdd3465841ec8a0ca9c96d6c14cb
Autor:
Michael R. Drumm, Wenxia Wang, Thomas K. Sears, Kirsten Bell-Burdett, Rodrigo Javier, Kristen Y. Cotton, Brynna Webb, Kayla Byrne, Dusten Unruh, Vineeth Thirunavu, Jordain Walshon, Alicia Steffens, Kathleen McCortney, Rimas V. Lukas, Joanna J. Phillips, Esraa Mohamed, John D. Finan, Lucas Santana-Santos, Amy B. Heimberger, Colin K. Franz, Jonathan Kurz, Jessica W. Templer, Geoffrey T. Swanson, Craig Horbinski
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
Seizures are a frequent complication of adult-type diffuse gliomas, and are often difficult to control with medications. Gliomas with mutations in isocitrate dehydrogenase 1 or 2 (IDHmut) are more likely than IDH–wild type (IDHwt) gliomas to cause
Externí odkaz:
https://doaj.org/article/7fc24269c7a640d7a68744806d41d5ca
Autor:
Matthew McCord, Alicia Steffens, Rodrigo Javier, Kwok-Ling Kam, Kathleen McCortney, Craig Horbinski
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-8 (2020)
Abstract A subset of gliomas has DNA repair defects that lead to hypermutated genomes. While such tumors are resistant to alkylating chemotherapies, they may also express more mutant neoantigens on their cell surfaces, and thus be more responsive to
Externí odkaz:
https://doaj.org/article/7a7eb0e3e82947c48f7eb930e5d8a6f8
Autor:
Michael Drumm, Wenxia Wang, Thomas K. Sears, Kirsten Bell-Burdett, Rodrigo Javier, Kristen Y. Cotton, Brynna T. Webb, Kayla T. Byrne, Dusten Unruh, Vineeth Thirunavu, Jordain Walshon, Alicia Steffens, Kathleen McCortney, Rimas V. Lukas, Joanna J. Phillips, Esraa Mohamed, John D. Finan, Lucas Santana-Santos, Amy B. Heimberger, Colin K. Franz, Jonathan E. Kurz, Jessica W. Templer, Geoffrey T. Swanson, Craig Horbinski
Publikováno v:
The Journal of clinical investigation, vol 133, iss 12
Seizures are a frequent complication of adult-type diffuse gliomas, and are often difficult to control with medications. Gliomas with mutations in isocitrate dehydrogenase 1 or 2 (IDHmut) are more likely than IDH-wild type (IDHwt) gliomas to cause se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125e96da5b909fb444616a484ece9056
https://escholarship.org/uc/item/1hp8c54d
https://escholarship.org/uc/item/1hp8c54d
Autor:
Kirsten Bell Burdett, Dusten Unruh, Michael Drumm, Alicia Steffens, Jonathan Lamano, Jonathan Judkins, Margaret Schwartz, Rodrigo Javier, Christina Amidei, Eric S. Lipp, Katherine B. Peters, Albert Lai, Blaine S. C. Eldred, Amy B. Heimberger, Kathleen McCortney, Denise M. Scholtens, Craig Horbinski
Publikováno v:
Blood.
Venous thromboembolism (VTE) is a life-threating condition that is common in patients with adult-type diffuse gliomas, yet thromboprophylaxis is controversial because of possible intracerebral hemorrhage. Effective VTE prediction models exist for oth
Autor:
Mireille, Bitar, Yevgen, Chornenkyy, Margaret E, Flanagan, Alicia, Steffens, Kathleen, McCortney, Craig, Horbinski
Publikováno v:
J Neuropathol Exp Neurol
While the coexistence of focal cortical dysplasia (FCD) and grade 1 noninfiltrative gliomas has been described, to date, only rare case reports have described FCD adjacent to infiltrating gliomas. We therefore sought to determine how often FCD-like f
Autor:
Kirsten B Burdett, Dusten Unruh, Michael Drumm, Jonathan Lamano, Margaret Schwartz, James Chandler, Rodrigo Javier, Alicia Steffens, Christina Amidei, Eric S Lipp, Katherine B Peters, Albert Lai, Blaine Eldred, Kathleen McCortney, Amy Heimberger, Denise Scholtens, Craig Horbinski
Publikováno v:
Neuro-Oncology. 24:vii241-vii242
Venous thromboembolism (VTE) is a common paraneoplastic complication in patients with adult-type diffuse gliomas. VTE greatly diminishes quality-of-life, and can even be life-threatening. While effective VTE prediction models exist for other cancers,
Autor:
Tyler J. Alban, Matthew M. Grabowski, Balint Otvos, Defne Bayik, Ajay Zalavadia, Vlad Makarov, Katie Troike, Mary McGraw, Anja Rabljenovic, Adam Lauko, Chase Neumann, Gustavo Roversi, Kristin A. Waite, Gino Cioffi, Nirav Patil, Thuy T. Tran, Kathleen McCortney, Alicia Steffens, C. Marcela Diaz, J. Mark Brown, Kathleen M. Egan, Craig M. Horbinski, Jill S. Barnholtz-Sloan, Michael A. Vogelbaum, Richard Bucala, Timothy A. Chan, Manmeet S. Ahluwalia, Justin D. Lathia
While immunotherapies have shown durable responses for multiple tumors, their efficacy remains limited in some advanced cancers, including glioblastoma. This may be due to differences in the immune landscape, as the glioblastoma microenvironment stro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18c740fdfe6628cb7a17646eb551b525
https://doi.org/10.1101/2022.03.07.483365
https://doi.org/10.1101/2022.03.07.483365
Autor:
Michael Drumm, Wenxia Wang, Kirsten B Burdett, Thomas Sears, Rodrigo Javier, Kristen Cotton, Brynna Webb, Jacob Stolz, Kayla Byrne, Dusten Unruh, Jordain Walshon, Alicia Steffens, Kathleen McCortney, Omar Bushara, Alyssa Weston, Suning He, Rimas Lukas, John Finan, Colin Franz, Jonathan Kurz, Jessica Templer, Geoff Swanson, Craig Horbinski
Publikováno v:
Neuro-Oncology. 24:vii27-vii27
Tumor-associated epilepsy (TAE) is a frequent complication of diffusely infiltrative gliomas, and impairs quality-of-life. We previously showed that isocitrate dehydrogenase 1 mutant (IDHmut) gliomas were associated with preoperative seizures, and th
Autor:
Adam Lauko, Josephine Volovetz, Soumya M. Turaga, Defne Bayik, Daniel J. Silver, Kelly Mitchell, Erin E. Mulkearns-Hubert, Dionysios C. Watson, Kiran Desai, Manav Midha, Jing Hao, Kathleen McCortney, Alicia Steffens, Ulhas Naik, Manmeet S. Ahluwalia, Shideng Bao, Craig Horbinski, Jennifer S. Yu, Justin D. Lathia
Despite therapeutic interventions for glioblastoma (GBM), cancer stem cells (CSCs) drive recurrence. The precise mechanisms underlying CSC therapeutic resistance, namely inhibition of cell death, are unclear. We built on previous observations that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3ff12d91437742d15e07e115d78457
https://doi.org/10.1101/2021.12.21.473663
https://doi.org/10.1101/2021.12.21.473663