Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Alicia Sedo"'
Autor:
Lisseth Estefania Burbano, Melody Li, Nikola Jancovski, Paymaan Jafar-Nejad, Kay Richards, Alicia Sedo, Armand Soriano, Ben Rollo, Linghan Jia, Elena V. Gazina, Sandra Piltz, Fatwa Adikusuma, Paul Q. Thomas, Helen Kopsidas, Frank Rigo, Christopher A. Reid, Snezana Maljevic, Steven Petrou
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
Developmental and epileptic encephalopathies (DEEs) are characterized by pharmaco-resistant seizures with concomitant intellectual disability. Epilepsy of infancy with migrating focal seizures (EIMFS) is one of the most severe of these syndromes. De
Externí odkaz:
https://doaj.org/article/94df65e871214a28a1b39d45e79f1372
Autor:
Jacqueline Heighway, Alicia Sedo, Anjali Garg, Lauren Eldershaw, Victoria Perreau, Géza Berecki, Christopher A. Reid, Steven Petrou, Snezana Maljevic
Publikováno v:
Neurobiology of Disease, Vol 164, Iss , Pp 105622- (2022)
Genetic variation in voltage-gated sodium (NaV) channels is a significant contributor to neurodevelopmental disorders. NaV channel alpha subunits are encoded by the SCNxA family and four are predominately expressed in the brain: SCN1A, SCN2A, SCN3A,
Externí odkaz:
https://doaj.org/article/a88bf1266bb841f19cdd910753febb18
Autor:
Sophie C. Payne, John B. Furness, Owen Burns, Alicia Sedo, Tomoko Hyakumura, Robert K. Shepherd, James B. Fallon
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Electrical stimulation of the cervical vagus nerve is an emerging treatment for inflammatory bowel disease (IBD). However, side effects from cervical vagal nerve stimulation (VNS) are often reported by patients. Here we hypothesized that stimulating
Externí odkaz:
https://doaj.org/article/fe6c99f407dc4d40b3faf2ffd3fb3a7c
Publikováno v:
Royal Society Open Science, Vol 5, Iss 3 (2018)
Inflammatory damage to the bowel, as occurs in inflammatory bowel disease (IBD), is debilitating to patients. In both patients and animal experimental models, histological analyses of biopsies and endoscopic examinations are used to evaluate the dise
Externí odkaz:
https://doaj.org/article/4c40e824a4c148be89d4a5958ac2e669
Autor:
Snezana Maljevic, Lisa Drew, Linghan Jia, Kelley Dalby, Melody Li, Svenja Pachernegg, Alex Nemiroff, Armand Soriano, Lisseth Estefania Burbano, Paymaan Jafar-Nejad, Nikola Jancovski, Frank Rigo, Steven Petrou, Blaine R. Roberts, Ben Rollo, Alicia Sedo, Kay L. Richards, Jacqueline Heighway, Todd Blackburn, Christopher A. Reid
Publikováno v:
J Clin Invest
Epilepsy is the neurological disorder defined by spontaneous recurrent seizures, which are abnormal patterns of electrical discharge in the brain. A major advance in neurology over the last 20 years is the identification of genetic variation as an im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57423a77538807e27d047e94a53f263a
https://europepmc.org/articles/PMC8631599/
https://europepmc.org/articles/PMC8631599/
Autor:
Martin J. Stebbing, Clive N. May, Angel de Silva, Frank Weissenborn, James B Fallon, John B. Furness, Robert K. Shepherd, Richard A. Williams, Owen Burns, Tomoko Hyakumura, Alicia Sedo, Sophie C. Payne, Mario Huynh, Ross Thomas
Publikováno v:
Bioelectronics in Medicine. 1:235-250
Aim: Electrical stimulation of the left cervical vagus nerve is a feasible therapy for inflammatory bowel disease (IBD). However, due to the location of the electrode placement, stimulation is often associated with side effects. Methods: We developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dc375f272f014bb097136daa2b7f232
https://doi.org/10.2217/bem-2018-0011
https://doi.org/10.2217/bem-2018-0011
Autor:
Alicia Sedo, Snezana Maljevic, Fatwa Adikusuma, Christopher A. Reid, Nikola Jancovski, Sandra Piltz, Kay L. Richards, Lisseth Estefania Burbano, Paul Q. Thomas, Steven Petrou, Benjamin N. Rollo, Paymaan Jafar-Nejad, Elena V. Gazina, Melody Li, Frank Rigo, Linghan Jia, Armand Soriano
Developmental and epileptic encephalopathies (DEE) are characterized by pharmacoresistant seizures with concomitant intellectual disability. Epilepsy of infancy with migrating focal seizures (EIMFS) is one of the most severe of these syndromes. De no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0fb43150df2e302c8c686d2ce2a913c
https://doi.org/10.1101/2020.11.12.379164
https://doi.org/10.1101/2020.11.12.379164
Autor:
Kay L. Richards, Lisa Drew, Linghan Jia, Alicia Sedo, Todd Blackburn, Snezana Maljevic, Blaine R. Roberts, Christopher A. Reid, Frank Rigo, Lisseth Estefania Burbano, Nikola Jancovski, Ben Rollo, Kelley Dalby, Paymaan Jafar-Nejad, Armand Soriano, Svenja Pachernegg, Alex Nemiroff, Melody Li, Steven Petrou
The clinical spectrum associated with SCN2A de novo mutations (DNMs) continues to expand and includes autism spectrum disorder with or without seizures, in addition to early and late seizure onset developmental and epileptic encephalopathies (DEEs).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c877e91548c11be57330fadfe50eaa58
https://doi.org/10.1101/2020.09.09.289900
https://doi.org/10.1101/2020.09.09.289900
Autor:
Ian C. Forster, Leonid Churilov, Samuel F. Berkovic, Snezana Maljevic, Ingrid E. Scheffer, Nikola Jancovski, Ming S Soh, Bina Santoro, Anirudh Kathirvel, Lauren E Bleakley, Christopher A. Reid, Alicia Sedo, Paulo Pinares-Garcia, Chaseley E McKenzie, Steven Petrou
Publikováno v:
Brain : a journal of neurology. 144(7)
Pathogenic variants in HCN1 are associated with developmental and epileptic encephalopathies. The recurrent de novo HCN1 M305L pathogenic variant is associated with severe developmental impairment and drug-resistant epilepsy. We engineered the homolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa368223bc77568058a17ad90da6299
https://pubmed.ncbi.nlm.nih.gov/34117499
https://pubmed.ncbi.nlm.nih.gov/34117499
Autor:
Justin F. X. Ainscough, Alicia Sedo, Michael Shires, David J. Beech, Paul D. Baxter, Stephen B. Wheatcroft, Mark T. Kearney, Baptiste Rode, Nadira Yuldasheva, Marc A. Bailey
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Transient Receptor Potential Canonical 5 (TRPC5) is a subunit of a Ca2+-permeable non-selective cationic channel which negatively regulates adiponectin but not leptin in mice fed chow diet. Adiponectin is a major anti-inflammatory mediator and so we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6101501357d35c103a991482e0497c72
https://eprints.whiterose.ac.uk/139591/8/s41598-018-37299-8.pdf
https://eprints.whiterose.ac.uk/139591/8/s41598-018-37299-8.pdf