Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Alicia R. Timme‐Laragy"'
Publikováno v:
Antioxidants, Vol 13, Iss 8, p 1006 (2024)
Activation of Nrf2—the master regulator of antioxidative response—at different stages of embryonic development has been shown to result in changes in gene expression, but the tissue-specific and downstream effects of Nrf2 activation during develo
Externí odkaz:
https://doaj.org/article/045e857eb5784868af16a4e3ed10d3b0
Publikováno v:
Journal of Diabetes, Vol 14, Iss 1, Pp 34-51 (2022)
Abstract Background Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by insulin resistance and failure of β‐cells to meet the metabolic demand for insulin. Recent advances in single‐cell RNA sequencing (sc‐RNA‐Seq) have all
Externí odkaz:
https://doaj.org/article/b11a986f52d0444d884ed0a0d894b949
Autor:
Archit Rastogi, Emily G. Severance, Haydee M. Jacobs, Sarah M. Conlin, Sadia T. Islam, Alicia R. Timme-Laragy
Publikováno v:
Redox Biology, Vol 38, Iss , Pp 101788- (2021)
Emerging evidence suggests that redox-active chemicals perturb pancreatic islet development. To better understand potential mechanisms for this, we used zebrafish (Danio rerio) embryos to investigate roles of glutathione (GSH; predominant cellular re
Externí odkaz:
https://doaj.org/article/d79f35c1f213476c943ef65c9022d0b9
Autor:
Archit Rastogi, Christopher W. Clark, Sarah M. Conlin, Sarah E. Brown, Alicia R. Timme-Laragy
Publikováno v:
Redox Biology, Vol 30, Iss , Pp - (2020)
Externí odkaz:
https://doaj.org/article/a740657fba354d01b10a7ddc07195108
Autor:
Archit Rastogi, Christopher W. Clark, Sarah M. Conlin, Sarah E. Brown, Alicia R. Timme-Laragy
Publikováno v:
Redox Biology, Vol 26, Iss , Pp - (2019)
Glutathione (GSH), the most abundant vertebrate endogenous redox buffer, plays key roles in organogenesis and embryonic development, however, organ-specific GSH utilization during development remains understudied. Monochlorobimane (MCB), a dye conjug
Externí odkaz:
https://doaj.org/article/7dc1db913e9143e0a446b8e0382acc39
Autor:
Karilyn E. Sant, Haydee M. Jacobs, Jiali Xu, Katrina A. Borofski, Larry G. Moss, Jennifer B. Moss, Alicia R. Timme-Laragy
Publikováno v:
Toxics, Vol 4, Iss 3, p 20 (2016)
The pancreatic islets, largely comprised of insulin-producing beta cells, play a critical role in endocrine signaling and glucose homeostasis. Because they have low levels of antioxidant defenses and a high perfusion rate, the endocrine islets may be
Externí odkaz:
https://doaj.org/article/0a853649a35a4df289a8e2a8338f3fe8
Publikováno v:
Journal of Diabetes. 14:34-51
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by insulin resistance and failure of β-cells to meet the metabolic demand for insulin. Recent advances in single-cell RNA sequencing (sc-RNA-Seq) have allowed for in-depth studies to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca39295ea05ff822dd2e07a596a5db63
https://doi.org/10.1111/1753-0407.13236
https://doi.org/10.1111/1753-0407.13236
Autor:
Emily S. Marques, Emily G. Severance, Bellis Min, Paige Arsenault, Sarah M. Conlin, Alicia R. Timme-Laragy
Publikováno v:
Free radical biologymedicine. 194
Dimethyl fumarate (DMF) is pharmaceutical activator of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), which regulates of many cellular antioxidant response pathways, and has been used to treat inflammatory diseases such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d4141f65d9170217b90010300bf543
https://pubmed.ncbi.nlm.nih.gov/36528121
https://pubmed.ncbi.nlm.nih.gov/36528121
Autor:
Monika A. Roy, Aarthi Mohan, Yankel Karasik, John E. Tobiason, David A. Reckhow, Alicia R. Timme‐Laragy
Publikováno v:
Environ Toxicol Chem
Traditional approaches toward evaluating oil spill mitigation effectiveness in drinking water supplies using analytical chemistry can overlook residual hydrocarbons and treatment byproducts of unknown toxicity. Zebrafish (Danio rerio) were used to ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe427f060a6dbac92c5db4712359eda9
https://europepmc.org/articles/PMC9711864/
https://europepmc.org/articles/PMC9711864/
Autor:
Emily R. Leonard, Emily S. Marques, Monika A. Roy, Sarah M. Conlin, Ravi Ranjan, Alicia R. Timme-Laragy
Publikováno v:
Food and Chemical Toxicology. 176:113788
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4b0ca1f3152f75e54930739bb0fa892
https://doi.org/10.1016/j.fct.2023.113788
https://doi.org/10.1016/j.fct.2023.113788