Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Alicia Purkey"'
Autor:
Peter J. Klauck, Stacey M. Bagby, Anna Capasso, Erica L. Bradshaw-Pierce, Heather M. Selby, Anna Spreafico, John J. Tentler, Aik Choon Tan, Jihye Kim, John J. Arcaroli, Alicia Purkey, Wells A. Messersmith, Keisuke Kuida, S. Gail Eckhardt, Todd M. Pitts
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background Polo-like kinase 1 (Plk1) is a serine/threonine kinase that is a key regulator of multiple stages of mitotic progression. Plk1 is upregulated in many tumor types including colorectal cancer (CRC) and portends a poor prognosis. TAK
Externí odkaz:
https://doaj.org/article/d4dd779ae0964c9eb1a995ae2b3952c9
Autor:
Aaron J Scott, Eun-Kee Song, Stacey Bagby, Alicia Purkey, Martin McCarter, Csaba Gajdos, Kevin S Quackenbush, Benjamin Cross, Todd M Pitts, Aik Choon Tan, S Gail Eckhardt, Hubert Fenton, John Arcaroli, Wells A Messersmith
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187173 (2017)
Dysregulation of the Src pathway has been shown to be important at various stages of cancer. Dasatinib is a potent Src/Abl inhibitor and has demonstrated to have anti-proliferative and anti-invasive activity in many preclinical models. The objective
Externí odkaz:
https://doaj.org/article/ffa9c06bfd5b415295825fb53b2a273e
Autor:
Todd M Pitts, Timothy P Newton, Erica L Bradshaw-Pierce, Rebecca Addison, John J Arcaroli, Peter J Klauck, Stacey M Bagby, Stephanie L Hyatt, Alicia Purkey, John J Tentler, Aik Choon Tan, Wells A Messersmith, S Gail Eckhardt, Stephen Leong
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113037 (2014)
The activation of the MAPK and PI3K/AKT/mTOR pathways is implicated in the majority of cancers. Activating mutations in both of these pathways has been described in colorectal cancer (CRC), thus indicating their potential as therapeutic targets. This
Externí odkaz:
https://doaj.org/article/b1c9a4e1dffc414aa91616e478557aca
Publikováno v:
Biological Psychiatry.
Autor:
Scott H. Soderling, Erik J. Soderblom, Patricia F. Maness, Tetsuya Takano, Katherine T. Baldwin, Jamie L Courtland, Akiyoshi Uezu, Alicia Purkey, John T Wallace, Tomomi Shimogori, Cagla Eroglu
Publikováno v:
Nature
Summary Perisynaptic astrocyte processes are an integral part of central nervous system synapses1,2; however, the molecular mechanisms governing astrocyte-synapse adhesions and how astrocyte contacts control synapse formation and function are largely
Autor:
Scott H. Soderling, Alicia Purkey, Yudong Gao, James O. McNamara, Eda Erata, Erik J. Soderblom
Publikováno v:
J Neurosci
Epilepsy Aphasia Syndromes (EAS) are a spectrum of childhood epileptic, cognitive, and language disorders of unknown etiology.CNKSR2is a strong X-linked candidate gene implicated in EAS; however, there have been no studies of genetic models to dissec
Autor:
Alicia Purkey, Mark L. Dell'Acqua
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 12 (2020)
Frontiers in Synaptic Neuroscience
Frontiers in Synaptic Neuroscience
Experience-dependent learning and memory require multiple forms of plasticity at hippocampal and cortical synapses that are regulated by N-methyl-D-aspartate receptors (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type ionot
Autor:
Keisuke Kuida, Anna Capasso, Peter J. Klauck, Todd M. Pitts, Stacey M. Bagby, Anna Spreafico, Wells A. Messersmith, John J. Arcaroli, Aik Choon Tan, S. Gail Eckhardt, Alicia Purkey, John J. Tentler, Jihye Kim, Heather M. Selby, Erica L. Bradshaw-Pierce
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
BMC Cancer
BMC Cancer
Background Polo-like kinase 1 (Plk1) is a serine/threonine kinase that is a key regulator of multiple stages of mitotic progression. Plk1 is upregulated in many tumor types including colorectal cancer (CRC) and portends a poor prognosis. TAK-960 is a
Autor:
S. Lindsey Davis, John J. Arcaroli, Alicia Purkey, Stacey M. Bagby, Stephanie L. Hyatt, Jennifer R. Diamond, S. Gail Eckhardt, Todd M. Pitts, Anna Spreafico, John J. Tentler, Kelly L. McPhillips, Peter J. Klauck, Wells A. Messersmith, Anna Capasso, Jeffery A Ecsedy, Aik Choon Tan, Erica L. Bradshaw-Pierce, Heather M. Selby
Publikováno v:
Oncotarget
// Todd M. Pitts 1, 3, * , Erica L. Bradshaw-Pierce 2, 3, 5, * , Stacey M. Bagby 1 , Stephanie L. Hyatt 1 , Heather M. Selby 1 , Anna Spreafico 1 , John J. Tentler 1, 3 , Kelly McPhillips 1 , Peter J. Klauck 1 , Anna Capasso 1 , Jennifer R. Diamond 1
Autor:
Kevin Quackenbush, Jihye Kim, Wells A. Messersmith, Justin Greene, S. Gail Eckhardt, Alicia Purkey, Patrick J. Blatchford, Guoliang Wang, Dexiang Gao, Alwin Schuller, Stacey M. Bagby, Wai Meng Tai, Anna R Schreiber, Anna Capasso, John J. Arcaroli, Todd M. Pitts, Anna Nguyen
Publikováno v:
Oncotarget
// Kevin S. Quackenbush 1 , Stacey Bagby 1 , Wai Meng Tai 1, 2 , Wells A. Messersmith 1 , Anna Schreiber 1 , Justin Greene 1 , Jihye Kim 1 , Guoliang Wang 1 , Alicia Purkey 1 , Todd M. Pitts 1 , Anna Nguyen 1 , Dexiang Gao 1 , Patrick Blatchford 1 ,