Výsledky vyhledávání - "Alicia Pedraza"

Akademický článek

miR-34a repression in proneural malignant gliomas upregulates expression of its target PDGFRA and promotes tumorigenesis.

Autor: Joachim Silber, Anders Jacobsen, Tatsuya Ozawa, Girish Harinath, Alicia Pedraza, Chris Sander, Eric C Holland, Jason T Huse

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33844 (2012)

Glioblastoma (GBM) and other malignant gliomas are aggressive primary neoplasms of the brain that exhibit notable refractivity to standard treatment regimens. Recent large-scale molecular profiling has revealed distinct disease subclasses within mali

Externí odkaz: https://doaj.org/article/62412012914a4a3a8f9e99a972369f90

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Akademický článek

Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations.

Autor: Cameron Brennan, Hiroyuki Momota, Dolores Hambardzumyan, Tatsuya Ozawa, Adesh Tandon, Alicia Pedraza, Eric Holland

Publikováno v: PLoS ONE, Vol 4, Iss 11, p e7752 (2009)

Glioblastoma multiforme (GBM) is an umbrella designation that includes a heterogeneous group of primary brain tumors. Several classification strategies of GBM have been reported, some by clinical course and others by resemblance to cell types either

Externí odkaz: https://doaj.org/article/fb5ade4e49f543b7922e0872d05f9115

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Interview with Dr. Mellinghoff from Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors

mp3 file (11 MB). In the May edition of the Cancer Discovery podcast, Science Writer Elizabeth McKenna talks with Ingo K. Mellinghoff about his paper, which suggests that the disappointing clinical activity of first-generation EGFR inhibitors in glio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ea84dde1575a2f19855b3499939fbe
https://doi.org/10.1158/2159-8290.22529031.v1

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Supplementary Figures 1-10 from Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors

PDF file - 689K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025f5ec99aaea9c2cde7f69d10999a40
https://doi.org/10.1158/2159-8290.22529022

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Supplementary Tables 1-8 from Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors

PDF file - 104K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb661e94c988b70550298ec4f5bac77
https://doi.org/10.1158/2159-8290.22529019

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Supplementary Figure and Table Legends, Methods from Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors

PDF file - 133K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb57c1393865c3b35670662aac40d7a
https://doi.org/10.1158/2159-8290.22529025.v1

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Cell-of-origin susceptibility to glioblastoma formation declines with neural lineage restriction

Autor: Elsa Vera, Alicia Pedraza, Zilai Wang, Luis F. Parada, Daochun Sun, Dennis K. Burns, Sheila R. Alcantara Llaguno

Publikováno v: Nature Neuroscience. 22:545-555

The contribution of lineage identity and differentiation state to malignant transformation is controversial. We have previously shown that adult neural stem and early progenitor cells give origin to glioblastoma. Here we systematically assessed the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de48a97f24fd05908a73cec490eb725a
https://doi.org/10.1038/s41593-018-0333-8

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Abstract LB024: Cancer stem cells are enriched in human recurrent glioblastoma

Autor: Xuanhua Peter Xie, Mungunsarnai Ganbold, Alicia Pedraza, Luis Parada

Publikováno v: Cancer Research. 82:LB024-LB024

A number of studies have described an essential role of cancer stem cells (CSC) in glioblastoma (GBM) progression and recurrence based on isolation by candidate markers. However, a systematic evaluation of the proposed CSC in paired human primary and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0117bbcfdf0f8888b2a5e7ad9b25418f
https://doi.org/10.1158/1538-7445.am2022-lb024

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TMOD-06. LOSS OF DICER COOPERATES WITH TUMOR SUPPRESSORS TO INITIATE METASTATIC MEDULLOBLASTOMA

Autor: Sheila R. Alcantara Llaguno, Olivier Saulnier, Andrea Ventura, Michael D. Taylor, Daochun Sun, Dennis K. Burns, Brian Gudenas, Luis F. Parada, Inga Nazarenko, Paul A. Northcott, Tejus Bale, Gaspare La Rocca, Alicia Pedraza, Yuntao Chen

Publikováno v: Neuro-Oncology

To determine the role of microRNA regulation in brain tumor development, we incorporated a conditional allele of the microRNA processing enzyme Dicer to a previously characterized glioma mouse model based on inactivation of the tumor suppressors Nf1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d0500c1a843683eb2dcbae5848555e
https://doi.org/10.1093/neuonc/noab090.147

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EGFR and PDGFRA co-expression and heterodimerization in glioblastoma tumor sphere lines

Autor: Aushim Kokroo, Cameron Brennan, Diana Punko, Grégoire Altan-Bonnet, Alicia Pedraza, Debyani Chakravarty, Angela H. Liu, Jason T. Huse, Jesse W. Cotari

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

Concurrent amplifications of EGFR and PDGFRA have been reported in up to 5% of glioblastoma (GBM) and it remains unclear why such independent amplification events, and associated receptor overexpression, would be adaptive during glioma evolution. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0cfada9f57007ec73dd4c0ae7ce688
http://europepmc.org/articles/PMC5567352

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