Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Alicia Ng"'
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15347 (2010)
The cholera toxin B pentamer (CtxB(5)), which belongs to the AB(5) toxin family, is used as a model study for protein assembly. The effect of the pH on the reassembly of the toxin was investigated using immunochemical, electrophoretic and spectroscop
Externí odkaz:
https://doaj.org/article/09d1de2905e541ea9b1e55caab71b035
Publikováno v:
Managing Sport and Leisure. 27:421-438
Purpose: There is a lack of analysis on players’ perceptions of mobile augmented reality (MAR) games and their sustainable effect. This study analyses Pokemon Go players motivation to play and thei...
Autor:
Tricia Protack, Michael A. Walker, Guo Li, David R. Langley, B. Narasimhulu Naidu, Nicholas A. Meanwell, George L. Trainor, Alicia Ng, Susan Jenkins, Mark Krystal, Zeyu Lin, Samuel Gerritz, Christopher Cianci, Hal A. Lewis, Kevin Kish, Javed Khan, Prasanna Sivaprakasam, Annapurna Pendri, Ira B. Dicker, Linda Discotto
Publikováno v:
Journal of Medicinal Chemistry. 63:2620-2637
The standard of care for HIV-1 infection, highly active antiretroviral therapy (HAART), combines two or more drugs from at least two classes. Even with the success of HAART, new drugs with novel mechanisms are needed to combat viral resistance, impro
Autor:
Jing, Alicia Ng Xuan, Rahmat, Ayu Wandira Binte, Shaie, Radin Nursyairah Binte Mohamed, Lian, Cheryl Pei Ling
Social media (SoMe) platforms have been widely explored as an educational tool, with early adopters reporting significant success1. An increasing number of healthcare institutions have been using SoMe for patient care and education, organizational pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf901c662955acac8db7c01f718d695
Autor:
Anuradha Gupta, Ira B. Dicker, Mark Krystal, Tricia Protack, Jacob Swidorski, Yoganand Shanmugam, Susan Jenkins, Alicia Ng, Umesh Hanumegowda, Nicholas A. Meanwell, Dawn D. Parker, Alicia Regueiro-Ren, Brett R. Beno
Publikováno v:
Bioorganicmedicinal chemistry letters. 36
GSK3532795 (formerly BMS-955176) is a second-generation HIV-1 maturation inhibitor that has shown broad spectrum antiviral activity and preclinical PK predictive of once-daily dosing in humans. Although efficacy was confirmed in clinical trials, the
Publikováno v:
Tetrahedron Letters. 59:751-754
Three novel tricyclic diamines (1,7-diazaisoadamantane, 1,5-diazaisoadamantane and 1,6-diazahomobrendane) were prepared. A flexible synthetic strategy was employed which used flat, aromatic azaindoles as the starting materials. The requisite azaindol
Publikováno v:
Tetrahedron Letters. 59:747-750
Synthesis of the novel tricyclic diamines 1,4-diazaisotwistane and 1,4-diazahomoisotwistane are described. These compact tricyclic cores have one tertiary and one secondary amine and may serve as ring-constrained isosteres of 3-aminoquinuclidine. Bot
Autor:
Alicia Ng, Ivar M. McDonald
Publikováno v:
Tetrahedron Letters. 59:755-759
Synthesis of the previously unreported 1,4-diazaadamantane is described. The overall strategy involves complete saturation of a flat, aromatic heterocycle, appropriate functionalization and intramolecular double alkylation. The alkylation takes place
Autor:
Kathleen W. Mosure, Michele Matchett, Ronald J. Knox, Richard E. Olson, Joanne J. Bronson, Nicholas A. Meanwell, Matthew G. Soars, Linda J. Bristow, Ramkumar Rajamani, James Herrington, Amy Easton, Digavalli V. Sivarao, Dawn D. Parker, Rick L. Pieschl, Ping Chen, Guanglin Luo, Omar S. Barnaby, Lorin A. Thompson, Yong-Jin Wu, Andrea McClure, Jason M. Guernon, Amy Newton, Alicia Ng, Clotilde Bourin, Carolyn Diane Dzierba
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:5490-5505
Since zwitterionic benzenesulfonamide Nav1.7 inhibitors suffer from poor membrane permeability, we sought to eliminate this characteristic by replacing the basic moiety with non-basic bicyclic acetals and monocyclic ethers. These efforts led to the d
Autor:
Katherine A. Grant-Young, Andrew Nickel, Rajesh Onkardas Bora, Prakash Anjanappa, Bender John A, Kevin Kish, Kap-Sun Yeung, Dawn D. Parker, Joseph Raybon, Mark R. Witmer, Karen Rigat, Matthew G. Soars, Steven Sheriff, Yue-Zhong Shu, Kenneth S. Santone, Prashantha Gunaga, Kyle Parcella, Nicholas A. Meanwell, Jay O. Knipe, Susan B. Roberts, Alicia Ng, Michael Sinz, Kathy Mosure, Ying-Kai Wang, Brett R. Beno, Mengping Liu, Elizabeth Colston, Dennis M. Grasela, John F. Kadow, Qi Gao, Min Gao, Umesh Hanumegowda, Roy Haskell, Julie A. Lemm, Xiaoliang Zhuo, Changhong Wan, Kumaravel Selvakumar
Publikováno v:
Journal of Medicinal Chemistry. 60:4369-4385
The hepatitis C virus (HCV) NS5B replicase is a prime target for the development of direct-acting antiviral drugs for the treatment of chronic HCV infection. Inspired by the overlay of bound structures of three structurally distinct NS5B palm site al