Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Alicia N Stein-Oakley"'
Autor:
Alicia N Stein-Oakley, Zygmunt S. Krozowski, John E. Dowling, Napier M. Thomson, Julie A. Maguire, Greg J. Perry
Publikováno v:
Nephrology. 4:81-86
SUMMARY: The enzyme 11β hydroxysteroid dehydrogenase type 2 (11βHSD2) converts glucocorticoids to their 11-keto metabolites, permitting binding of aldosterone to the non-selective mineralocorticoid receptor. Recent studies have suggested that 11βH
Autor:
Julie A. Maguire, Darren J. Kelly, Richard E. Gilbert, Yuan Zhang, Napier M. Thomson, Jennifer L. Wilkinson-Berka, Lesley Wassef, Takehiko Koji, Alicia N Stein-Oakley
Publikováno v:
Nephrology. 9:7-13
SUMMARY: Background and Aim: Tubular atrophy is a major feature of most renal diseases and is closely associated with the loss of renal function. The present study sought to investigate whether Fas/FasL-induced tubular epithelial cell apoptosis was a
Publikováno v:
Journal of Cardiovascular Pharmacology. 36:S367-S370
Whilst endothelin (ET) receptor antagonism has been evaluated in post-myocardial infarction (MI) remodeling, endothelin-converting enzyme (ECE) inhibition has not been determined. In the study reported here female Sprague-Dawley rats underwent corona
Autor:
Hironobu Sasano, Robin E. Smith, K X Z Li, Zygmunt S. Krozowski, Tim J Cole, V.R. Obeyesekere, C Coulter, Karen E. Sheppard, K Koyama, Alicia N Stein-Oakley
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 69:391-401
Local tissue concentrations of glucocorticoids are modulated by the enzyme 11 β -hydroxysteroid dehydrogenase which interconverts cortisol and the inactive glucocorticoid cortisone in man, and corticosterone and 11-dehydrocorticosterone in rodents.
Publikováno v:
Transplant International. 12:18-26
Non-allogeneic factors such as increased nephron “workload” may contribute to chronic renal allograft rejection. Reducing dietary protein from 20 % to 8 % was tested in a model of chronic rejection: Dark Agouti kidney to Albino Surgery recipient,
Autor:
Alicia N Stein-Oakley, Ewout A. Kouwenhoven, Paula Jablonski, Napier M. Thomson, Ron W. F. de Bruin
Publikováno v:
Digestive Diseases and Sciences. 44:1117-1123
Long-term survival of small bowel transplants ishampered by chronic rejection. Epidermal growth factor(EGF) and transforming growth factor β (TGF-β)have opposing, regulatory roles in normal intestinal physiology and may be involved in thepathogenes
Autor:
Troels Glysing-Jensen, Alicia N Stein-Oakley, Mary E. Russell, Patricia L. Mottram, Anne Räisänen-Sokolowski
Publikováno v:
Transplantation. 66:1510-1518
BACKGROUND To evaluate cardiac allografts from recipients that had achieved peripheral tolerance after transient CD4+ T cell depletion, we analyzed cellular infiltrate, cytokine expression, and vascular thickening. Long-surviving cardiac allografts f
Autor:
Wenruo Han, Julie A. Maguire, Thomas E. Mandel, Lisa Murray-Segal, Patricia L Mottram, Alicia N Stein-Oakley
Publikováno v:
Diabetes. 47:1399-1405
Spontaneously diabetic nonobese diabetic (NOD/Lt) mice were treated with anti-T-cell monoclonal antibodies (mAbs) at the time of grafting with vascularized segmental pancreas isografts. Recipients were either untreated or given anti-CD4 and/or anti-C
Autor:
Patricia L. Mottram, Anne Räisänen-Sokolowski, Troels Glysing-Jensen, Alicia N. Stein-Oakley, Mary E. Russell2
Publikováno v:
The Journal of Immunology. 161:602-609
To study the role of IL-4 in tolerance induction and transplant arteriosclerosis, BALB/c hearts were transplanted into C57BL/6J wild-type or IL-4 knockout (IL-4−/−) recipients. A 30-day course of anti-CD4/8 mAb was used to induce long term graft
Publikováno v:
Transplantation. 63:911-914
We analyzed cytokine expression in recipient spleens and cardiac allografts placed in mice that were unable to synthesize interleukin (IL)-4 due to disruption of the IL-4 gene (IL-4 -/-) and in wild-type (IL-4 +/+) mice. Polyclonal BL-4P and monoclon