Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Alicia Middlemas"'
Publikováno v:
Diabetes. 53:1851-1856
This study examined the role of p38 mitogen-activated protein (MAP) kinase in transducing high glucose into deficits in nerve conduction velocity (NCV) that are characteristic of diabetic neuropathy. p38 activation and NCV were measured in streptozoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b871f53c05e164c4a9da46b54f8b2c45
https://doi.org/10.2337/diabetes.53.7.1851
https://doi.org/10.2337/diabetes.53.7.1851
Autor:
David R. Tomlinson, Jean Dominique Delcroix, Renee I. Shapiro, Rigel Ranciato, Jason D. Freshwater, Frederick R. Taylor, Monica L. Burgers, Andrew P. Mizisin, Thomas Engber, Nigel A. Calcutt, Henryk Dudek, Alicia Middlemas, Alphonse Galdes, Karen L. Allendoerfer, Lee L. Rubin, Kathy Strauch
Publikováno v:
Journal of Clinical Investigation. 111:507-514
Hedgehog proteins modulate development and patterning of the embryonic nervous system. As expression of desert hedgehog and the hedgehog receptor, patched-1, persist in the postnatal and adult peripheral nerves, the hedgehog pathway may have a role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4d71bb1ba3b9443143906b4eb35848
https://doi.org/10.1172/jci200315792
https://doi.org/10.1172/jci200315792
Autor:
Paul Fernyhough, Edward B. Jude, Tertia D. Purves, Andrew J.M. Boulton, Alicia Middlemas, Sithiporn Agthong, David R. Tomlinson
Publikováno v:
The FASEB Journal. 15:2508-2514
The onset of diabetic neuropathy, a complication of diabetes mellitus, has been linked to poor glycemic control. We tested the hypothesis that the mitogen-activated protein kinases (MAPK) form transducers for the damaging effects of high glucose. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94861102cb8477da008afbfa184fa9a9
https://doi.org/10.1096/fj.01-0253hyp
https://doi.org/10.1096/fj.01-0253hyp
Publikováno v:
Diabetologia. 49(3)
This study was designed to determine whether diabetes in rats is associated with phosphorylation of c-Jun N-terminal kinase (JNK) and one of its transcription factors, c-Jun, in sensory neurones innervating the lower limb. We also sought to determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5907bcdd32d626dc27f40ec92397e0fe
https://pubmed.ncbi.nlm.nih.gov/16456679
https://pubmed.ncbi.nlm.nih.gov/16456679
Publikováno v:
Diabetologia. 47(11)
This study tested the premise that immunoreactivity representing the p75 neurotrophin receptor (p75(NTR)) appears in plasma of diabetic rats in association with the early stages of neuronal dysfunction or damage. We also examined whether treatment be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce30f8409ed3e130f6a0bc9fda4210a6
https://pubmed.ncbi.nlm.nih.gov/15558233
https://pubmed.ncbi.nlm.nih.gov/15558233
Autor:
David R. Tomlinson, Alicia Middlemas, Lisa J. Beswick, Nicola M. Sayers, Paul Fernyhough, Andrew P. Mizisin, Nigel A. Calcutt
Publikováno v:
Diabetes. 52(9)
The relation between neurofilament expression and/or phosphorylation in the proximal versus distal components of the sensory peripheral neuraxis was studied and related to disorders in structure and function of the distal axon of streptozocin (STZ)-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a716f423f48b88d50cd60a43b2bef9c7
https://pubmed.ncbi.nlm.nih.gov/12941778
https://pubmed.ncbi.nlm.nih.gov/12941778
Autor:
David R. Tomlinson, Jean-Dominique Delcroix, Nicola M. Sayers, Alicia Middlemas, Paul Fernyhough
Publikováno v:
Brain : a journal of neurology. 126(Pt 7)
The objective was to determine whether stress-activated protein kinases (SAPKs) mediated the transfer of diabetes-induced stress signals from the periphery to somata of sensory neurons. Thus, we characterized axonal transport of SAPKs in peripheral n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae347585570e9fd6e9ddb5ac18895a9
https://pubmed.ncbi.nlm.nih.gov/12805110
https://pubmed.ncbi.nlm.nih.gov/12805110