Výsledky vyhledávání - "Alicia M. Arkell"

Central-acting therapeutics alleviate respiratory weakness caused by heart failure–induced ventilatory overdrive

Autor: Ashley L. Eadie, Jason S. Huber, Jeremy A. Simpson, Coral L. Murrant, Andrew J. Foster, Keith R. Brunt, Alicia M. Arkell, Mathew J. Platt, David C. Wright, Nadya Romanova, Todd E. Gillis

Publikováno v: Science Translational Medicine. 9

Diaphragmatic weakness is a feature of heart failure (HF) associated with dyspnea and exertional fatigue. Most studies have focused on advanced stages of HF, leaving the cause unresolved. The long-standing theory is that pulmonary edema imposes a mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::804b2fc7be4c3b2a1db34cf02983c0a6
https://doi.org/10.1126/scitranslmed.aag1303

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The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass

Autor: Sabina Paglialunga, Genevieve Simnett, Holly Robson, Monica Hoang, Mark O. Huising, Arend Bonen, Renjitha Pillai, Jamie W. Joseph, Alicia M. Arkell, Graham P. Holloway, Jeremy A. Simpson

Publikováno v: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 42(6)

Tre-2/USP6, BUB2, cdc16 domain family, member 1 (TBC1D1), a Rab-GTPase activating protein, is a paralogue of AS160, and has been implicated in the canonical insulin-signaling cascade in peripheral tissues. More recently, TBC1D1 was identified in rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f64a8197bbb6dc53c90410cfa6118d1
https://pubmed.ncbi.nlm.nih.gov/28177704

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Novel effects of rosiglitazone on SMAD2 and SMAD3 signaling in white adipose tissue of diabetic rats

Autor: Alicia M. Arkell, Graham P. Holloway, Zhongxiao Wan, David C. Wright, Amanda L. Stefanson, Laelie A. Snook, Marie-Soleil Beaudoin, Jeremy A. Simpson

Publikováno v: Obesity. 22:1632-1642

Objective The effects of the proliferator-activated receptor gamma (PPARγ) agonist rosiglitazone (ROSI) on the transforming growth factor (TGF)-β/SMAD signaling pathway in white adipose tissue (WAT) of diabetic rats were assessed. Methods Six-week-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::664f689daeb7a62996bad99deed6f584
https://doi.org/10.1002/oby.20717

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Resveratrol supplementation improves white adipose tissue function in a depot-specific manner in Zucker diabetic fatty rats

Autor: Alicia M. Arkell, Graham P. Holloway, Jeremy A. Simpson, David C. Wright, Laelie A. Snook, Marie-Soleil Beaudoin

Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 305:R542-R551

Resveratrol (RSV) is a polyphenolic compound suggested to have anti-diabetic properties. Surprisingly, little is known regarding the effects of RSV supplementation on adipose tissue (AT) metabolism in vivo. The purpose of this study was to assess the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51245f45f6515b1a3b0495ee16b15273
https://doi.org/10.1152/ajpregu.00200.2013

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Exercise-mediated IL-6 signaling occurs independent of inflammation and is amplified by training in mouse adipose tissue

Autor: Christopher G. R. Perry, Rebecca E. K. MacPherson, Alicia M. Arkell, Jeremy A. Simpson, David C. Wright, Jason S. Huber, Jared Root-McCaig, Laura Castellani

Publikováno v: Journal of applied physiology (Bethesda, Md. : 1985). 119(11)

The purpose of this investigation was to determine whether exercise-induced increases in adipose tissue interleukin 6 (IL-6) signaling occurred as part of a larger proinflammatory response to exercise and whether the induction of IL-6 signaling with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b0db3cbc90e98da771308b46f08cf2
https://pubmed.ncbi.nlm.nih.gov/26472868

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Respiratory muscle weakness in the Zucker diabetic fatty rat

Autor: David C. Wright, Andrew J. Foster, Nadya Romanova, Melissa A. Allwood, Marie-Soleil Beaudoin, Coral L. Murrant, Alicia M. Arkell, Graham P. Holloway, Laelie A. Snook, Jeremy A. Simpson

Publikováno v: American journal of physiology. Regulatory, integrative and comparative physiology. 309(7)

The obesity epidemic is considered one of the most serious public health problems of the modern world. Physical therapy is the most accessible form of treatment; however, compliance is a major obstacle due to exercise intolerance and dyspnea. Respira

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aabe7c805a7c881ef885d773b771418
https://pubmed.ncbi.nlm.nih.gov/26246509

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Profound lung remodeling in heart failure, a poorly understood phenomenon with a significant impact (715.6)

Autor: Jeremy A. Simpson, Andrew J. Foster, Mathew J. Platt, Kayla Dadgar, Coral L. Murrant, Alicia M. Arkell

Publikováno v: The FASEB Journal. 28

Exercise intolerance, characterized by dyspnea and early onset of exertional fatigue, is a chief complaint among patients with heart failure (HF). Limb muscle dysfunction is a known contributor to ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5867d24a37f1f4866a2bac51e9d9bbc7
https://doi.org/10.1096/fasebj.28.1_supplement.715.6

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Novel effects of rosiglitazone on SMAD2 and SMAD3 signaling in white adipose tissue of diabetic rats

Autor: Marie-Soleil, Beaudoin, Laelie A, Snook, Alicia M, Arkell, Amanda, Stefanson, Zhongxiao, Wan, Jeremy A, Simpson, Graham P, Holloway, David C, Wright

Publikováno v: Obesity (Silver Spring, Md.). 22(7)

The effects of the proliferator-activated receptor gamma (PPARγ) agonist rosiglitazone (ROSI) on the transforming growth factor (TGF)-β/SMAD signaling pathway in white adipose tissue (WAT) of diabetic rats were assessed.Six-week-old, male ZDF rats

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fb5801f4979835753c541fe057ceb52b
https://pubmed.ncbi.nlm.nih.gov/24500776

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