Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alicia M Saarinen"'
Autor:
Michael W Moran, Elizabeth P Ramirez, James D Zook, Alicia M Saarinen, Bobby Baravati, Matthew R Goode, Vasiliki Laloudakis, Emily K Kaschner, Tien L Olson, Felicia M Craciunescu, Debra T Hansen, Jun Liu, Petra Fromme
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0249164 (2021)
In the United States non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease, affecting an estimated 80 to 100 million people. It occurs in every age group, but predominantly in people with risk factors such as obes
Externí odkaz:
https://doaj.org/article/df709f94f5d2437182ca1909b6b7e4f4
Autor:
Xiaodong Zhang, Alicia M Saarinen, Taro Hitosugi, Zhenghe Wang, Liguo Wang, Thai H Ho, Jun Liu
Publikováno v:
eLife, Vol 6 (2017)
Tumor tissues are chronically exposed to hypoxia owing to aberrant vascularity. Lipid droplet (LD) accumulation is a hallmark of hypoxic cancer cells, yet how LDs form and function during hypoxia remains poorly understood. Herein, we report that in v
Externí odkaz:
https://doaj.org/article/1b9ee07bf78f458881f4e43d9bb425db
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156742 (2016)
Intracellular triglyceride (TG) hydrolysis or lipolysis is catalyzed by the key intracellular triglyceride hydrolase, adipose triglyceride lipase (ATGL). The G0/G1 Switch Gene 2 (G0S2) was recently identified as the major selective inhibitor of ATGL
Externí odkaz:
https://doaj.org/article/85b45c92355845b683845bddbf755557
Autor:
Xiaodong Zhang, Rudolf Zechner, Haiwei Gu, Bradlee L. Heckmann, Xitao Xie, Alicia M. Saarinen, Jun Liu
Publikováno v:
The FASEB Journal. 33:6655-6666
G0/G1 switch gene 2 (G0S2) is a specific inhibitor of adipose triglyceride lipase (ATGL), the rate-limiting enzyme for intracellular lipolysis. Recent studies show that G0S2 plays a critical role in promoting triacylglycerol (TG) accumulation in the
Autor:
Matthew R. Goode, Tien L. Olson, Jun Liu, Alicia M. Saarinen, Emily K. Kaschner, Petra Fromme, Felicia M. Craciunescu, James Zook, Debra T. Hansen, Michael W. Moran, Elizabeth P. Ramirez, Vasiliki Laloudakis, Bobby Baravati
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0249164 (2021)
PLoS ONE, Vol 16, Iss 7, p e0249164 (2021)
In the United States non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease, affecting an estimated 80 to 100 million people. It occurs in every age group, but predominantly in people with risk factors such as obes
Publikováno v:
Diabetes
Melanocortin 2 receptor accessory protein (MRAP) is highly expressed in adrenal gland and adipose tissue. In adrenal cells, MRAP is essential for adrenocorticotropic hormone (ACTH)–induced activation of the cAMP/protein kinase A (PKA) pathway by me
Autor:
Thai H. Ho, Liguo Wang, Taro Hitosugi, Xiaodong Zhang, Jun Liu, Zhenghe Wang, Alicia M. Saarinen
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
Tumor tissues are chronically exposed to hypoxia owing to aberrant vascularity. Lipid droplet (LD) accumulation is a hallmark of hypoxic cancer cells, yet how LDs form and function during hypoxia remains poorly understood. Herein, we report that in v
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 307:E1047-E1056
Fat-specific protein 27 (FSP27) plays a pivotal role in controlling the formation of large lipid droplet and energy metabolism. The cellular levels of FSP27 are tightly regulated through the proteasomal ubiquitin-mediated degradation. However, the up
Autor:
Alicia M. Saarinen, Zhenghe Wang, Thai H. Ho, Liguo Wang, Xiaodong Zhang, Jun Liu, Taro Hitosugi
Tumor tissues are chronically exposed to hypoxia owing to aberrant vascularity. Lipid droplet (LD) accumulation is a hallmark of hypoxic cancer cells, yet how LDs form and function during hypoxia remains poorly understood. Herein, we report that in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63a088ad9f1c9a856637a70cbcb84fc