Výsledky vyhledávání - "Alicia M Kemble"

Akademický článek

A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature

Autor: Alicia M. Kemble, Benoit Hornsperger, Iris Ruf, Hans Richter, Jörg Benz, Bernd Kuhn, Dominik Heer, Matthias Wittwer, Britta Engelhardt, Uwe Grether, Ludovic Collin

Publikováno v: PLoS ONE, Vol 17, Iss 9 (2022)

Chronic inflammation and blood–brain barrier dysfunction are key pathological hallmarks of neurological disorders such as multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. Major drivers of these pathologies include pro-inflammato

Externí odkaz: https://doaj.org/article/d34faf86a82540f88518f79cdabc62d6

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Akademický článek

TGFβ1 Induces Senescence and Attenuated VEGF Production in Retinal Pericytes

Autor: Dragana Avramovic, Sébastien A. Archaimbault, Alicia M. Kemble, Sabine Gruener, Mirjana Lazendic, Peter D. Westenskow

Publikováno v: Biomedicines, Vol 10, Iss 6, p 1404 (2022)

Diabetic retinopathy (DR) is a microvascular disease of the retina and a serious complication of type I and type II diabetes mellitus. DR affects working-age populations and can cause permanent vision loss if left untreated. The standard of care for

Externí odkaz: https://doaj.org/article/3323befb46514c7a87d52460012cab93

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Akademický článek

Brain Shuttle Neprilysin reduces central Amyloid-β levels.

Autor: Christopher R Campos, Alicia M Kemble, Jens Niewoehner, Per-Ola Freskgård, Eduard Urich

Publikováno v: PLoS ONE, Vol 15, Iss 3, p e0229850 (2020)

Reducing Amyloid β (Aβ) in the brain is of fundamental importance for advancing the therapeutics for Alzheimer`s disease. The endogenous metallopeptidase neprilysin (NEP) has been identified as one of the key Aβ-degrading enzymes. Delivery of NEP

Externí odkaz: https://doaj.org/article/aa89271f13884ee2b314a47af6c49151

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