Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alicia M, McConnell"'
Autor:
Elisabeth Roider, Alexandra I. T. Lakatos, Alicia M. McConnell, Poguang Wang, Alina Mueller, Akinori Kawakami, Jennifer Tsoi, Botond L. Szabolcs, Anna A. Ascsillán, Yusuke Suita, Vivien Igras, Jennifer A. Lo, Jennifer J. Hsiao, Rebecca Lapides, Dorottya M. P. Pál, Anna S. Lengyel, Alexander Navarini, Arimichi Okazaki, Othon Iliopoulos, István Németh, Thomas G. Graeber, Leonard Zon, Roger W. Giese, Lajos V. Kemeny, David E. Fisher
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Microphthalmia-associated transcription factor (MITF) is a master regulator of melanocyte function, development and plays a significant role in melanoma pathogenesis. MITF genomic amplification promotes melanoma development, and it can facil
Externí odkaz:
https://doaj.org/article/cc94d2d3111647cfb25391c16c6a03e3
Autor:
Haley R Noonan, Alexandra M Thornock, Julia Barbano, Michael E Xifaras, Chloe S Baron, Song Yang, Katherine Koczirka, Alicia M McConnell, Leonard I Zon
Publikováno v:
eLife, Vol 13 (2024)
Developmental signaling pathways associated with growth factors such as TGFb are commonly dysregulated in melanoma. Here we identified a human TGFb enhancer specifically activated in melanoma cells treated with TGFB1 ligand. We generated stable trans
Externí odkaz:
https://doaj.org/article/f51748881cd9498bbfd7139601c881b1
Autor:
Samriddha Ray, Norika Chiba, Changfu Yao, Xiangrong Guan, Alicia M. McConnell, Brian Brockway, Loretta Que, Jonathan L. McQualter, Barry R. Stripp
Publikováno v:
Stem Cell Reports, Vol 7, Iss 5, Pp 817-825 (2016)
Recent studies have implicated keratin 5 (KRT5)+ cells in repopulation of damaged lung tissue following severe H1N1 influenza virus infection. However, the origins of the cells repopulating the injured alveolar region remain controversial. We sought
Externí odkaz:
https://doaj.org/article/9b355db8be0741ccb60c116800efca0f
Autor:
Haley R. Noonan, Julia Barbano, Michael Xifaras, Chloé S. Baron, Song Yang, Katherine Koczirka, Alicia M. McConnell, Leonard I. Zon
Developmental signaling pathways associated with growth factors such as TGFb are commonly dysregulated in melanoma. Here we identified a human TGFb enhancer specifically activated in melanoma cells treated with TGFB1 ligand. We generated stable trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dd37eb17c54caec98188152a4724cc5
https://doi.org/10.1101/2022.09.29.510035
https://doi.org/10.1101/2022.09.29.510035
Publikováno v:
Annual Review of Cancer Biology. 5:331-350
Zebrafish are rapidly becoming a leading model organism for cancer research. The genetic pathways driving cancer are highly conserved between zebrafish and humans, and the ability to easily manipulate the zebrafish genome to rapidly generate transgen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f888916d26bb5b3f59703797beff2a8d
https://doi.org/10.1146/annurev-cancerbio-051320-014135
https://doi.org/10.1146/annurev-cancerbio-051320-014135
Autor:
Marlies P. Rossmann, Maurizio Fazio, Dorothee Bornhorst, Michael J. Fairchild, Avik Choudhuri, Leonard I. Zon, Jodi Weiss, Shannon Freyer, Audrey Sporrij, Iris T. Chan, Rodsy Modhurima, Julien Ablain, Meera Prasad, Hadley M Moreau, Margaret C. Weber, Meredith E. Stanhope, Elliott J. Hagedorn, Jason D. Boisvert, Julia Barbano, Serine Avagyan, Mackenzie Smith, Alicia M. McConnell, Rebecca J. Freeman
Publikováno v:
Cell. 184(7)
Many scientists spend unnecessary time reformatting papers to submit them to different journals. We propose a uniform submission format that we hope journals will include in their options for submission. Widespread adoption of this uniform submission
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637c42768bf2f66ea06e7e2483505fb6
https://pubmed.ncbi.nlm.nih.gov/33798436
https://pubmed.ncbi.nlm.nih.gov/33798436
Autor:
Leonard I. Zon, Alicia M. McConnell
Publikováno v:
Nat Cell Biol
In humans, epidermal melanocytes are responsible for skin pigmentation, defence against ultraviolet radiation and the deadliest common skin cancer, melanoma. Although there is substantial overlap in melanocyte development pathways between different m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::262b85b20237936e463042d5c7c9ba1f
https://doi.org/10.1038/s41556-021-00748-0
https://doi.org/10.1038/s41556-021-00748-0
Autor:
Jennifer J. Hsiao, Ju Hee Lee, Hequn Wang, Francisco Rothhammer, Conor L. Evans, Kazumasa Wakamatsu, Vivien Igras, David E. Fisher, Alicia M. McConnell, Jianming Zhang, Paula P. Navarro, Maria Vittoria Schiaffino, Luba M. Pardo, Gabriel Bedoya, Kathleen A. Christie, Antonio Cozzio, Tamar Nijsten, Thomas Ruzicka, Victor Acuna-Alonso, Giovanni Poletti, Luke H. Chao, Carla Gallo, Kaspar Itin, Othon Iliopoulos, Qing Yu Weng, Shosuke Ito, Alexander A. Navarini, Lajos Kemény, Kaustubh Adhikari, Akinori Kawakami, Yusuke Suita, Shaohua Fan, Haley R. Noonan, Nisma Mujahid, Camila Makhlouta Lugo, Elisabeth Roider, Inbal Rachmin, Samuel Canizales-Quinteros, Leonard I. Zon, Maria Cátira Bortolini, Alyssa Lovas, Chong Hyun Won, István Németh, Jennifer A. Lo, Nhu T. Nguyen, Benjamin P. Kleinstiver, Jennifer Allouche, Sarah A. Tishkoff, Carola Berking, Andres Ruiz-Linares, Rolando González-José, Sam Osseiran, Shinichiro Kato
Publikováno v:
Cell, 184(16), 4268-4283.e20. Cell Press
Ultraviolet (UV) light and incompletely understood genetic and epigenetic variations determine skin color. Here we describe an UV- and microphthalmia-associated transcription factor (MITF)-independent mechanism of skin pigmentation. Targeting the mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add0c8ea673a321afb32113e2f1a35c6
http://www.scopus.com/inward/record.url?scp=85111783140&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85111783140&partnerID=8YFLogxK
Autor:
Parviz Minoo, Min Li, Zea Borok, Agnes Banfalvi, Barry R. Stripp, Mitsuhiro Sunohara, Manda S. Krishnaveni, Janice M. Liebler, Alicia M. McConnell, Per Flodby, Dan R. Castillo, Edward D. Crandall, Beiyun Zhou
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 312:L131-L142
Previous studies have demonstrated resistance to naphthalene-induced injury in proximal airways of mice with lung epithelial-specific deletion of the tumor-suppressor gene Pten, attributed to increased proliferation of airway progenitors. We tested e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4acd2960c06254f416b94f60b8676ca6
https://doi.org/10.1152/ajplung.00005.2015
https://doi.org/10.1152/ajplung.00005.2015
Autor:
Alicia M. McConnell, Brian Brockway, Norika Chiba, Changfu Yao, Samriddha Ray, Xiangrong Guan, Loretta G. Que, Barry R. Stripp, Jonathan L. McQualter
Publikováno v:
Stem cell reports, vol 7, iss 5
Stem Cell Reports, Vol 7, Iss 5, Pp 817-825 (2016)
Stem Cell Reports, Vol 7, Iss 5, Pp 817-825 (2016)
SummaryRecent studies have implicated keratin 5 (KRT5)+ cells in repopulation of damaged lung tissue following severe H1N1 influenza virus infection. However, the origins of the cells repopulating the injured alveolar region remain controversial. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c8e37efb0a0c558d44b37a60120379