Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Alicia Lindeman"'
Autor:
Inês A. M. Barbosa, Rajaraman Gopalakrishnan, Samuele Mercan, Thanos P. Mourikis, Typhaine Martin, Simon Wengert, Caibin Sheng, Fei Ji, Rui Lopes, Judith Knehr, Marc Altorfer, Alicia Lindeman, Carsten Russ, Ulrike Naumann, Javad Golji, Kathleen Sprouffske, Louise Barys, Luca Tordella, Dirk Schübeler, Tobias Schmelzle, Giorgio G. Galli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract YAP is a key transcriptional co-activator of TEADs, it regulates cell growth and is frequently activated in cancer. In Malignant Pleural Mesothelioma (MPM), YAP is activated by loss-of-function mutations in upstream components of the Hippo p
Externí odkaz:
https://doaj.org/article/e2b59d291ce047f9846c8773ccba1759
Autor:
Atanu Paul, Stefano Annunziato, Bo Lu, Tianliang Sun, Olivera Evrova, Lara Planas-Paz, Vanessa Orsini, Luigi M. Terracciano, Olga Charlat, Zinger Yang Loureiro, Lei Ji, Raffaella Zamponi, Frederic Sigoillot, Hong Lei, Alicia Lindeman, Carsten Russ, John S. Reece-Hoyes, Thomas B. Nicholson, Jan S. Tchorz, Feng Cong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
How cell-cell contact is sensed by Hippo pathway is poorly understood. Here, the authors show that KIRREL1 functions as a feedback regulator of the mammalian Hippo pathway by sensing cell-cell interaction and recruiting SAV1 to cell-cell contacts.
Externí odkaz:
https://doaj.org/article/bfe690555e05477e9caae7da26bcc89a
Autor:
Carlos G. Sanchez, Christopher M. Acker, Audrey Gray, Malini Varadarajan, Cheng Song, Nadire R. Cochran, Steven Paula, Alicia Lindeman, Shaojian An, Gregory McAllister, John Alford, John Reece-Hoyes, Carsten Russ, Lucas Craig, Ketthsy Capre, Christian Doherty, Gregory R. Hoffman, Sarah J. Luchansky, Manuela Polydoro, Ricardo Dolmetsch, Fiona Elwood
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Using an unbiased genome-wide CRISPR screen approach, Sanchez et al. identified modulators of endogenous tau protein. This study suggests that chromatin modifiers, neddylation, ubiquitination, and the mTOR pathways regulate overall levels of tau prot
Externí odkaz:
https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a2
Autor:
Marek J Kobylarz, Jonathan M Goodwin, Zhao B Kang, John W Annand, Sarah Hevi, Ellen O'Mahony, Gregory McAllister, John Reece-Hoyes, Qiong Wang, John Alford, Carsten Russ, Alicia Lindeman, Martin Beibel, Guglielmo Roma, Walter Carbone, Judith Knehr, Joseph Loureiro, Christophe Antczak, Dmitri Wiederschain, Leon O Murphy, Suchithra Menon, Beat Nyfeler
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0235551 (2020)
VPS34 is a key regulator of endomembrane dynamics and cargo trafficking, and is essential in cultured cell lines and in mice. To better characterize the role of VPS34 in cell growth, we performed unbiased cell line profiling studies with the selectiv
Externí odkaz:
https://doaj.org/article/405ec165a99f440886a38bc379ff0399
Autor:
Anastasia Hyrina, Christopher Jones, Darlene Chen, Scott Clarkson, Nadire Cochran, Paul Feucht, Gregory Hoffman, Alicia Lindeman, Carsten Russ, Frederic Sigoillot, Tiffany Tsang, Kyoko Uehara, Lili Xie, Don Ganem, Meghan Holdorf
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 2970-2978.e6 (2019)
Summary: A hallmark of chronic hepatitis B (CHB) virus infection is the presence of high circulating levels of non-infectious small lipid HBV surface antigen (HBsAg) vesicles. Although rare, sustained HBsAg loss is the idealized endpoint of any CHB t
Externí odkaz:
https://doaj.org/article/1de14fd71bb445e89c5fdea311bfc65e
Autor:
Jonathan M. Goodwin, William E. Dowdle, Rowena DeJesus, Zuncai Wang, Philip Bergman, Marek Kobylarz, Alicia Lindeman, Ramnik J. Xavier, Gregory McAllister, Beat Nyfeler, Gregory Hoffman, Leon O. Murphy
Publikováno v:
Cell Reports, Vol 20, Iss 10, Pp 2341-2356 (2017)
Iron is vital for many homeostatic processes, and its liberation from ferritin nanocages occurs in the lysosome. Studies indicate that ferritin and its binding partner nuclear receptor coactivator-4 (NCOA4) are targeted to lysosomes by a form of sele
Externí odkaz:
https://doaj.org/article/24a5ed36c1ec4393b84541c3dfccc45e
Autor:
Hao Zeng, Johnny Castillo-Cabrera, Mika Manser, Bo Lu, Zinger Yang, Vaik Strande, Damien Begue, Raffaella Zamponi, Shumei Qiu, Frederic Sigoillot, Qiong Wang, Alicia Lindeman, John S Reece-Hoyes, Carsten Russ, Debora Bonenfant, Xiaomo Jiang, Youzhen Wang, Feng Cong
Publikováno v:
eLife, Vol 8 (2019)
EGFR-mutant NSCLCs frequently respond to EGFR tyrosine kinase inhibitors (TKIs). However, the responses are not durable, and the magnitude of tumor regression is variable, suggesting the existence of genetic modifiers of EGFR dependency. Here, we app
Externí odkaz:
https://doaj.org/article/2f4c85fb4b8e4572b5af26dcb106d8f3
Autor:
Fiona Elwood, John Alford, Carsten Russ, Christopher Acker, Audrey Gray, John S. Reece-Hoyes, Carlos G Sanchez, Sarah J. Luchansky, Christian Doherty, Lucas Craig, Gregory McAllister, Steven Paula, Ricardo E. Dolmetsch, Shaojian An, Cheng Song, Alicia Lindeman, Malini Varadarajan, Nadire Cochran, Manuela Polydoro, Ketthsy Capre, Gregory R. Hoffman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
Communications Biology
Aggregates of hyperphosphorylated tau protein are a pathological hallmark of more than 20 distinct neurodegenerative diseases, including Alzheimer’s disease, progressive supranuclear palsy, and frontotemporal dementia. While the exact mechanism of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a06bbe1da74cbde2af5f7fb1d3fc80e
https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a2
https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a2
Autor:
Jingyao Li, Daniel J. Ho, Martin Henault, Chian Yang, Marilisa Neri, Robin Ge, Steffen Renner, Leandra Mansur, Alicia Lindeman, Brian Kelly, Tayfun Tumkaya, Xiaoling Ke, Gilberto Soler-Llavina, Gopi Shanker, Carsten Russ, Marc Hild, Caroline Gubser Keller, Jeremy L. Jenkins, Kathleen A. Worringer, Frederic D. Sigoillot, Robert J. Ihry
Publikováno v:
ACS chemical biology. 17(6)
Unbiased transcriptomic RNA-seq data has provided deep insights into biological processes. However, its impact in drug discovery has been narrow given high costs and low throughput. Proof-of-concept studies with Digital RNA with pertUrbation of Genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84df92c55bb23f5e3de70243ffd28703
https://pubmed.ncbi.nlm.nih.gov/35508359
https://pubmed.ncbi.nlm.nih.gov/35508359
Autor:
Rowena DeJesus, Francesca Moretti, Gregory McAllister, Zuncai Wang, Phil Bergman, Shanming Liu, Elizabeth Frias, John Alford, John S Reece-Hoyes, Alicia Lindeman, Jennifer Kelliher, Carsten Russ, Judith Knehr, Walter Carbone, Martin Beibel, Guglielmo Roma, Aylwin Ng, John A Tallarico, Jeffery A Porter, Ramnik J Xavier, Craig Mickanin, Leon O Murphy, Gregory R Hoffman, Beat Nyfeler
Publikováno v:
eLife, Vol 5 (2016)
SQSTM1 is an adaptor protein that integrates multiple cellular signaling pathways and whose expression is tightly regulated at the transcriptional and post-translational level. Here, we describe a forward genetic screening paradigm exploiting CRISPR-
Externí odkaz:
https://doaj.org/article/740ed0340cbe47708079afcf989db0dd