Výsledky vyhledávání - "Alicia Klatt"

Transcription termination factor Pcf11 limits the processivity of Pol II on an HIV provirus to repress gene expression

Autor: David S. Gilmour, Andrew J. Henderson, Zhiqiang Zhang, Alicia Klatt

Publikováno v: Genes & Development. 21:1609-1614

Many elongation factors in eukaryotes promote gene expression by increasing the processivity of RNA polymerase II (Pol II). However, the stability of RNA Pol II elongation complexes suggests that such complexes are not inherently prone to prematurely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bec86fc0781734d681218b39d23000b
https://doi.org/10.1101/gad.1542707

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Function of Small Hydrophobic Proteins of Paramyxovirus

Autor: Alicia Klatt, Andrew J. Henderson, Rebecca L. Wilson, Ping Wang, Erica C. Taddeo, Biao He, Sandra Fuentes

Publikováno v: Journal of Virology. 80:1700-1709

Mumps virus (MuV), a rubulavirus of the paramyxovirus family, causes acute infections in humans. MuV has seven genes including a small hydrophobic (SH) gene, which encodes a type I membrane protein of 57 amino acid residues. The function of the SH pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3197a7a0eb1c3465ede0d5b21c5da60e
https://doi.org/10.1128/jvi.80.4.1700-1709.2006

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RON Receptor Tyrosine Kinase, a Negative Regulator of Inflammation, Inhibits HIV-1 Transcription in Monocytes/Macrophages and Is Decreased in Brain Tissue from Patients with AIDS

Autor: Alicia Klatt, Shigeki Tsutsui, Christopher Power, Pamela H. Correll, Janet Holden, Eileen S. Lee, Parisa Kalantari, Andrew J. Henderson

Publikováno v: Scopus-Elsevier

Activation of macrophages and microglia cells after HIV-1 infection and their production of inflammatory mediators contribute to HIV-associated CNS diseases. The mechanisms that initiate and maintain inflammation after HIV-1 infection in the brain ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2aad95a213d8bfef7a000b578f9dfd
https://doi.org/10.4049/jimmunol.173.11.6864

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The receptor tyrosine kinase RON represses HIV-1 transcription by targeting RNA polymerase II processivity

Autor: David S. Gilmour, Andrew J. Henderson, Zhiqiang Zhang, Parisa Kalantari, Alicia Klatt, Pamela A. Hankey

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 180(3)

Efficient HIV-1 transcription requires the induction of cellular transcription factors, such as NF-κB, and the viral factor Tat, which through the recruitment of P-TEFb enhances processive transcription. However, whether cellular signals repress HIV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602d84865a1d857fa18fd7ec7b93836f
https://pubmed.ncbi.nlm.nih.gov/18209063

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Negative elongation factor NELF represses human immunodeficiency virus transcription by pausing the RNA polymerase II complex

Autor: Zhiqiang Zhang, Alicia Klatt, Andrew J. Henderson, David S. Gilmour

Publikováno v: The Journal of biological chemistry. 282(23)

Human immunodeficiency virus (HIV) transcription requires virally encoded Tat and the P-TEFb protein complex, which together associate with the Tat-activating region, a structured region in the nascent transcript. P-TEFb phosphorylates Proteins in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8104287ac8d38e9550a6b22a287737ec
https://pubmed.ncbi.nlm.nih.gov/17442680

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