Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Alicia K. Fleming"'
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106820- (2023)
Summary: The innate immune system has a key role in pancreatic cancer initiation, but the specific contribution of different macrophage populations is still ill-defined. While inflammatory (M1) macrophages have been shown to drive acinar-to-ductal me
Externí odkaz:
https://doaj.org/article/ee1aeaca9d56411a9f284027194122df
Autor:
Alicia K. Fleming Martinez, Heike R. Döppler, Ligia I. Bastea, Brandy H. Edenfield, Geou-Yarh Liou, Peter Storz
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104327- (2022)
Summary: Desmoplasia around pancreatic lesions is a barrier for immune cells and a hallmark of developing and established pancreatic cancer. However, the contribution of the innate immune system to this process is ill-defined. Using the KC mouse mode
Externí odkaz:
https://doaj.org/article/91998440ba57446fb25042eefda52ac9
Autor:
Alicia K. Fleming Martinez, Heike R. Döppler, Ligia I. Bastea, Brandy Edenfield, Tushar Patel, Michael Leitges, Geou-Yarh Liou, Peter Storz
Publikováno v:
iScience, Vol 24, Iss 1, Pp 102019- (2021)
Summary: Doublecortin-like kinase 1 (DCLK1)-positive pancreatic cancer stem cells develop at a precancerous stage and may contribute to the lack of efficacy of pancreatic cancer therapy. Although PanIN cells express oncogenic KRas and have an increas
Externí odkaz:
https://doaj.org/article/97c1c4b06bc6435e98af436af67fd633
Akademický článek
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Akademický článek
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Autor:
Peter Storz, Han W. Tun, John A. Copland, Brandy Edenfield, Yushi Qiu, Zhimin Li, Heike Doeppler, Christina A. von Roemeling, Alicia K. Fleming, Veethika Pandey, Geou-Yarh Liou, Ligia I. Bastea
During development of pancreatic cancer, alternatively activated macrophages contribute to fibrogenesis, pancreatic intraepithelial neoplasia (PanIN) lesion growth, and generation of an immunosuppressive environment. Here, we show that the immunomodu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e12837990510f18ebbd3400428cc9d6
https://doi.org/10.1158/0008-5472.c.6511409.v1
https://doi.org/10.1158/0008-5472.c.6511409.v1
Autor:
Peter Storz, Han W. Tun, John A. Copland, Brandy Edenfield, Yushi Qiu, Zhimin Li, Heike Doeppler, Christina A. von Roemeling, Alicia K. Fleming, Veethika Pandey, Geou-Yarh Liou, Ligia I. Bastea
Supplementary Table 1: Table with antibodies and dilutions used Supplementary Figure S1: Treatment scheme and analyses of stroma Supplementary Figure S2: Additional analyses of cell death and cell proliferation Supplementary Figure S3: Presence of Ym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90023b04345c94e26a82a044c0273455
https://doi.org/10.1158/0008-5472.22423040.v1
https://doi.org/10.1158/0008-5472.22423040.v1
Akademický článek
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Publikováno v:
Cancer Research. 83:4779-4779
Mitochondrially-generated reactive oxygen species (mROS) have been shown to induce acinar-to-ductal metaplasia (ADM). ADM, in presence of an oncogenic KRAS mutation, is an initiating step for progression to pancreatic intraepithelial neoplasia (PanIN
Publikováno v:
Cancer Research. 83:4775-4775
Recent studies demonstrate that mitochondrially-generated reactive oxygen species (ROS) downstream of oncogenic KRAS drive acinar-to-ductal metaplasia (ADM), a key first step in the pancreatic ductal adenocarcinoma (PDA) progression model. MnSOD/SOD2