Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Alicia J, El Haj"'
Autor:
Angela Imere, Nicola C. Foster, Hadi Hajiali, Kerime Ebrar Okur, Abigail L. Wright, Ines A. Barroso, Alicia J. El Haj
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Cartilage tissue engineering aims to develop functional substitutes for treating cartilage defects and osteoarthritis. Traditional two-dimensional (2D) cell culture systems lack the complexity of native cartilage, leading to the development
Externí odkaz:
https://doaj.org/article/b423fb40a2644c6bbf19ad5f688b3608
Autor:
David Gothard, Michael Rotherham, Emma L. Smith, Janos M. Kanczler, James Henstock, Julia A. Wells, Carol A. Roberts, Omar Qutachi, Heather Peto, Hassan Rashidi, Luis Rojo, Lisa J. White, Molly M. Stevens, Alicia J. El Haj, Felicity R.A.J. Rose, Richard O.C. Oreffo
Publikováno v:
Mechanobiology in Medicine, Vol 2, Iss 4, Pp 100096- (2024)
Bone tissue engineering requires a combination of materials, cells, growth factors and mechanical cues to recapitulate bone formation. In this study we evaluated hybrid hydrogels for minimally invasive bone formation by combining biomaterials with sk
Externí odkaz:
https://doaj.org/article/3563f34844174e618665c8ac5821cd93
Autor:
Candice Ashmore-Harris, Evangelia Antonopoulou, Simon M. Finney, Melissa R. Vieira, Matthew G. Hennessy, Andreas Muench, Wei-Yu Lu, Victoria L. Gadd, Alicia J. El Haj, Stuart J. Forbes, Sarah L. Waters
Publikováno v:
npj Regenerative Medicine, Vol 9, Iss 1, Pp 1-10 (2024)
Abstract Cell therapies are emerging as promising treatments for a range of liver diseases but translational bottlenecks still remain including: securing and assessing the safe and effective delivery of cells to the disease site; ensuring successful
Externí odkaz:
https://doaj.org/article/ae003db3cf7c435db3b3e580984070d7
Publikováno v:
Frontiers in Biomaterials Science, Vol 3 (2024)
The mechanical performance of tissue-engineered grafts is crucial in determining their functional properties, integration with native tissue and long-term repair outcome post-implantation. To date, most approaches for testing the mechanical propertie
Externí odkaz:
https://doaj.org/article/07a884288f8a4f8d895da142a11df55c
Autor:
James I. Kennedy, Scott P. Davies, Peter W. Hewett, Alex L. Wilkinson, Ye H. Oo, Wei-Yu Lu, Alicia J. El Haj, Shishir Shetty
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Immunotherapy has changed the landscape of treatment options for patients with hepatocellular cancer. Checkpoint inhibitors are now standard of care for patients with advanced tumours, yet the majority remain resistant to this therapy and urgent appr
Externí odkaz:
https://doaj.org/article/a2ab91cef8bf48c791a2da90a324bdec
Donor variability of ovine bone marrow derived mesenchymal stem cell - implications for cell therapy
Publikováno v:
International Journal of Veterinary Science and Medicine, Vol 11, Iss 1, Pp 23-37 (2023)
ABSTRACTIt is assumed that all species, including sheep, demonstrate significant variation between individuals including the characteristics of their bone marrow-derived mesenchymal stem cells (BM-MSCs). These differences may account for limited succ
Externí odkaz:
https://doaj.org/article/190a07fd9f6c4928a9ee51122b6a2fe0
Autor:
Jonathan H. Mason, Lu Luo, Yvonne Reinwald, Matteo Taffetani, Amelia Hallas-Potts, C. Simon Herrington, Vlastimil Srsen, Chih-Jen Lin, Inês A. Barroso, Zhihua Zhang, Zhibing Zhang, Anita K. Ghag, Ying Yang, Sarah Waters, Alicia J. El Haj, Pierre O. Bagnaninchi
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract The role of the mechanical environment in defining tissue function, development and growth has been shown to be fundamental. Assessment of the changes in stiffness of tissue matrices at multiple scales has relied mostly on invasive and often
Externí odkaz:
https://doaj.org/article/95572a8e392d40478e89ceb9f93489fc
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 21 (2023)
Bone regeneration and repair are complex processes in the adult skeleton, and current research has focused on understanding and controlling these processes. Magnetic nanoparticle (MNP)-based platforms have shown potential in tissue engineering and re
Externí odkaz:
https://doaj.org/article/59fd347e20c546e795e5cfc2ed66064d
Publikováno v:
Gels, Vol 9, Iss 11, p 915 (2023)
In the biomedical field, there is a demand for the development of novel approaches for the investigation of optical epithelial anatomical features with biomimetic materials. These materials are not only required to replicate structures but also enabl
Externí odkaz:
https://doaj.org/article/b6de878eb6f9435caa8e957d51aebb83
Autor:
Michael Rotherham, Yasamin Moradi, Tasmin Nahar, Dominic Mosses, Neil Telling, Alicia J. El Haj
Publikováno v:
Frontiers in Medical Technology, Vol 4 (2022)
TWIK-related K+ 1 (TREK1) is a potassium channel expressed in the nervous system with multiple functions including neurotransmission and is a prime pharmacological target for neurological disorders. TREK1 gating is controlled by a wide range of exter
Externí odkaz:
https://doaj.org/article/f622db2762c64d91b5373a94387c989b