Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Alicia Goodwin"'
Persistent repression of tau in the brain using engineered zinc finger protein transcription factors
Autor:
Susanne Wegmann, Bradley T. Hyman, Annemarie Ledeboer, Jeffrey C. Miller, Marta Perez-Rando, Kimberly Marlen, Richard T. Surosky, Bryan Zeitler, Caitlin Commins, Alison Chase, Michael C. Holmes, Sarah J. Hinkley, Alicia Goodwin, Riley N. Bannon, Lei Zhang, Brigit E. Riley, Hoang-Oanh B. Nguyen, Sarah L. DeVos, Edward J. Rebar, Ashley B. Robbins, Stephen Lam, Rainier Amora, Irina Ankoudinova, Qi Yu, Amy M. Pooler, Hung Tran, Nicholas A. Scarlott, Bianca T. Corjuc, Danny MacKenzie, Fyodor D. Urnov, H. Steve Zhang, Lisa Diez, Rachel E. Bennett
Publikováno v:
Science advances 7(12), eabe1611-(2021). doi:10.1126/sciadv.abe1611
Science Advances
Science Advances
Zinc finger proteins targeted to MAPT safely repress tau mRNA in the adult mouse brain and protect against Aβ toxicity.
Neuronal tau reduction confers resilience against β-amyloid and tau-related neurotoxicity in vitro and in vivo. Here, we in
Neuronal tau reduction confers resilience against β-amyloid and tau-related neurotoxicity in vitro and in vivo. Here, we in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1e249560ae8a0539e415f467dba78e
Autor:
Dale Genji Ando, Eudean Garces, Lei Zhang, Andrea J. Kang, Michael C. Holmes, Kate Nesbitt, Hung Tran, Brigit E. Riley, Courtney Dwyer, Geoff Nichol, Kassandra Hebert, Alicia Goodwin, Kathleen Meyer, Stephen Ballaron, Jeff Boonsripisal, Judith Greengard, David Lillicrap, Dominique Cartier, Christine Hough, Richard T. Surosky
Publikováno v:
Blood. 128:1173-1173
Hemophilia A, which is caused by a mutation in the Factor 8 (F8) gene resulting in a deficiency or lack of the Factor VIII (FVIII) protein, is the most common inherited bleeding disorder in humans with an estimated worldwide incidence of half a milli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a10f0dd18d67d57aaf5e4ab6ee016b6d
https://doi.org/10.1182/blood.v128.22.1173.1173
https://doi.org/10.1182/blood.v128.22.1173.1173
Autor:
Frank Y. Chang, Sarah A. Collins, Awatef Ergai, Esteban Gershanik, Brittany Couture, Zachary P. Katsulis, Jessica Cleveland, Ann Debord Smith, Naoaki Ichihara, Alicia Goodwin
Publikováno v:
CIN: Computers, Informatics, Nursing. 33:225-226
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f25250fdd2d37949e3454aae6ee5bdc1
https://doi.org/10.1097/01.ncn.0000466962.17866.8d
https://doi.org/10.1097/01.ncn.0000466962.17866.8d
Autor:
Jeff Boonsripisal, Geoff Nichol, Eudean Garces, Hung Tran, Stephen Ballaron, Lei Zhang, Alicia Goodwin, Richard T. Surosky, Judy Greengard, Andrea J. Kang, Michael C. Holmes, Brigit E. Riley, Kathleen Meyer, Dale Ando
Publikováno v:
Molecular Therapy. 24:S271
Hemophilia A is the most common inherited bleeding disorder in humans and is caused by a deficiency of blood coagulation factor VIII (FVIII). This disease is an ideal candidate for liver-directed gene therapy, as even modest increases in FVIII activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed23f464cb4f8958b1f36bdccd30a2f8
https://doi.org/10.1016/s1525-0016(16)33492-x
https://doi.org/10.1016/s1525-0016(16)33492-x
Publikováno v:
SPIE Proceedings.
Structural and compositional analysis of normal and pathological tissues by OCT often is performed ex vivo and subsequently compared to the histology. Many of the tissues of interest require immediate fixation to prevent degradation of the sample. Fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::307d8b2a6ea1f3ac024084d327955a17
https://doi.org/10.1117/12.646575
https://doi.org/10.1117/12.646575