Neuroprotection by neuregulin-1 following focal stroke is associated with the attenuation of ischemia-induced pro-inflammatory and stress gene expression

Autor: Zhenfeng Xu, Gregory D. Ford, DaJoie R. Croslan, Ju Jiang, Alicia Gates, Robert Allen, Byron D. Ford

Publikováno v: Neurobiology of Disease, Vol 19, Iss 3, Pp 461-470 (2005)

Neuregulins are a family of growth factors with potent neuroprotective properties. We recently demonstrated that neuregulin-1 blocked delayed neuronal death following focal ischemic stroke in the rat. Focal ischemia results in the release of pro-infl

Externí odkaz: https://doaj.org/article/2dbb8065cf3d40fb8eef5a512ca600e0

Bilateral gene interaction hierarchy analysis of the cell death gene response emphasizes the significance of cell cycle genes following unilateral traumatic brain injury

Autor: Alicia Gates, Todd E. White, Michelle C. LaPlaca, Benem-Orom Davids, Byron D. Ford, Monique C. Surles-Zeigler, Timothy J. Distel, Gregory D. Ford

Publikováno v: White, TE; Surles-Zeigler, MC; Ford, GD; Gates, AS; Davids, B; Distel, T; et al.(2016). Bilateral gene interaction hierarchy analysis of the cell death gene response emphasizes the significance of cell cycle genes following unilateral traumatic brain injury. BMC GENOMICS, 17. doi: 10.1186/s12864-016-2412-0. UC Riverside: Retrieved from: http://www.escholarship.org/uc/item/7w48r1rw
BMC genomics, vol 17, iss 1
BMC Genomics

Background Delayed or secondary cell death that is caused by a cascade of cellular and molecular processes initiated by traumatic brain injury (TBI) may be reduced or prevented if an effective neuroprotective strategy is employed. Microarray and subs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45118f431478a3494c3a5c5500cb9476
https://doi.org/10.1186/s12864-016-2412-0

Neuroprotective effects of neuregulin-1 on B35 neuronal cells following ischemia

Autor: Matthew C. Schoell, Byron D. Ford, DaJoie R. Croslan, Alicia Gates, Adalynn E. Harris, Gregory D. Ford, John V.K. Pulliam, Ceilessia M. Clement

Publikováno v: Brain Research. 1210:39-47

We previously showed that neuregulin-1 (NRG-1) protected neurons from death in vivo following focal ischemia. The goal of this study was to develop an in vitro rat ischemia model to examine the cellular and molecular mechanisms involved in the neurop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625d4f5a2c088f4610939fc99d3dd674
https://doi.org/10.1016/j.brainres.2008.02.059

Gene expression patterns following unilateral traumatic brain injury reveals a local pro-inflammatory and remote anti-inflammatory response

Autor: Gregory D. Ford, Michelle C. LaPlaca, Byron D. Ford, Todd E. White, Monique C. Surles-Zeigler, Alicia Gates

Publikováno v: BMC Genomics
BMC genomics, vol 14, iss 1

Background Traumatic brain injury (TBI) results in irreversible damage at the site of impact and initiates cellular and molecular processes that lead to secondary neural injury in the surrounding tissue. We used microarray analysis to determine which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe1eb56034f35689348523c7946fdd3
https://doi.org/10.1186/1471-2164-14-282

Agonist mediated internalization of M2 mAChR is beta-arrestin-dependent

Autor: Kymry T, Jones, Maria, Echeverry, Valerie A, Mosser, Alicia, Gates, Darrell A, Jackson

Publikováno v: Journal of Molecular Signaling

Muscarinic acetylcholine receptors (mAChRs) undergo agonist-promoted internalization, but evidence suggesting that the mechanism of internalization is beta-arrestin dependent has been contradictory and unclear. Previous studies using heterologous ove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c05f5beab5f51073be6f0601d47e924b
https://pubmed.ncbi.nlm.nih.gov/17224084