Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Alicia G. Arroyo"'
Autor:
Ricardo Santamaría, Javier Cruz-Caballero, Polyxeni Gkontra, Alberto Jiménez-Montiel, Cristina Clemente, Juan A. López, María Villalba-Orero, Jesús Vázquez, Andreas Hutloff, Enrique Lara-Pezzi, Alicia G. Arroyo
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: Removal of poorly perfused capillaries by pruning contributes to remodeling the microvasculature to optimize oxygen and nutrient delivery. Blood flow drives this process by promoting the intravascular migration of endothelial cells in d
Externí odkaz:
https://doaj.org/article/59b3226bfe404e288216a94b75cf606a
Autor:
Álvaro Sahún-Español, Cristina Clemente, Juan Ignacio Jiménez-Loygorri, Elena Sierra-Filardi, Leticia Herrera-Melle, Aurora Gómez-Durán, Guadalupe Sabio, María Monsalve, Patricia Boya, Alicia G. Arroyo
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Vascular smooth muscle cell (VSMC) proliferation is essential for arteriogenesis to restore blood flow after artery occlusion, but the mechanisms underlying this response remain unclear. Based on our previous findings showing increased VSMC
Externí odkaz:
https://doaj.org/article/81136b27965542ae88667a51280b8dac
Autor:
Mara Martín-Alonso, Sharif Iqbal, Pia M. Vornewald, Håvard T. Lindholm, Mirjam J. Damen, Fernando Martínez, Sigrid Hoel, Alberto Díez-Sánchez, Maarten Altelaar, Pekka Katajisto, Alicia G. Arroyo, Menno J. Oudhoff
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
While the role of smooth muscle in peristalsis has been studied extensively, little is known about its other functions in the intestine. Here the authors identify MMP17, expressed by smooth muscle cells, as a modulator of intestinal epithelial regene
Externí odkaz:
https://doaj.org/article/8dd66dd807d54c32a63b16e262a5ef10
Autor:
Francisca Mulero, Marta Oteo, Guillermo Garaulet, Natalia Magro, Lluvia Rebollo, Guillermo Medrano, Clara Santiveri, Eduardo Romero, Ricela E. Sellek, Yago Margolles, Ramón Campos-Olivas, Alicia G. Arroyo, Luis Angel Fernández, Miguel Angel Morcillo, Jorge L. Martínez-Torrecuadrada
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Triple-negative breast cancer (TNBC) is characterized by aggressiveness and high rates of metastasis. The identification of relevant biomarkers is crucial to improve outcomes for TNBC patients. Membrane type 1-matrix metalloproteinase (MT1-MMP) could
Externí odkaz:
https://doaj.org/article/9f56d62e2e19476389ae4a1143daab5c
Autor:
Emma Muñoz-Sáez, Natalia Moracho, Ana I. R. Learte, Alice Collignon, Alicia G. Arroyo, Agnés Noel, Nor Eddine Sounni, Cristina Sánchez-Camacho
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 9944 (2023)
MT4-MMP (or MMP-17) belongs to the membrane-type matrix metalloproteinases (MT-MMPs), a distinct subset of the MMP family that is anchored to the cell surface, in this case by a glycosylphosphatidylinositol (GPI) motif. Its expression in a variety of
Externí odkaz:
https://doaj.org/article/145035a10e32442dafc75070b327682f
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Patrolling monocytes (PMo) are the organism’s preeminent intravascular guardians by their continuous search of damaged endothelial cells and harmful microparticles for their removal and to restore homeostasis. This surveillance is accomplished by P
Externí odkaz:
https://doaj.org/article/494fc2c04ee6461386a1b0a9568c112d
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The vasculature ensures optimal delivery of nutrients and oxygen throughout the body, and to achieve this function it must continually adapt to varying tissue demands. Newly formed vascular plexuses during development are immature and require dynamic
Externí odkaz:
https://doaj.org/article/15f75e0d0b104b17aaa03a7369bd4699
Autor:
Wencke Walter, Laura Alonso-Herranz, Verdiana Trappetti, Isaac Crespo, Mark Ibberson, Marta Cedenilla, Anna Karaszewska, Vanessa Núñez, Ioannis Xenarios, Alicia G. Arroyo, Fátima Sánchez-Cabo, Mercedes Ricote
Publikováno v:
Cell Reports, Vol 23, Iss 2, Pp 622-636 (2018)
Summary: Macrophage plasticity has been studied in vitro, but transcriptional regulation upon injury is poorly understood. We generated a valuable dataset that captures transcriptional changes in the healthy heart and after myocardial injury, reveali
Externí odkaz:
https://doaj.org/article/721d14f41e1e4b898bd97eda2c18063b
Autor:
Cristina Clemente, Cristina Rius, Laura Alonso-Herranz, Mara Martín-Alonso, Ángela Pollán, Emilio Camafeita, Fernando Martínez, Rubén A. Mota, Vanessa Núñez, Cristina Rodríguez, Motoharu Seiki, José Martínez-González, Vicente Andrés, Mercedes Ricote, Alicia G. Arroyo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Matrix metalloproteinases (MMP) are involved in vascular remodeling associated with plaque progression. Little is known about their immune regulatory role in vascular disorders. Here, the authors report that MT4-MMP-deficiency increases the recruitme
Externí odkaz:
https://doaj.org/article/e0c0b515953e43daab3696ec2826dc83
Autor:
Emma Muñoz-Sáez, Natalia Moracho, Ana I. R. Learte, Alicia G. Arroyo, Cristina Sánchez-Camacho
Publikováno v:
Cells, Vol 10, Iss 9, p 2448 (2021)
MT1-MMP/MMP14 belongs to a subgroup of the matrix metalloproteinases family that presents a transmembrane domain, with a cytosolic tail and the catalytic site exposed to the extracellular space. Deficient mice for this enzyme result in early postnata
Externí odkaz:
https://doaj.org/article/3eaebd3732594e848ac1ce7ccbcd30b0