Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Alicia Cole"'
Autor:
Diwakar Davar, Arivarasan Karunamurthy, Joe-Marc Chauvin, Robert Morrison, Yulong Bai, Jie Sun, Julie Stein, Richard Rodrigues, John McCulloch, Hong Wang, Douglas Hartman, Miriam Fernandes, Alicia Cole, Amiran Dzutsev, Christopher Deitrick, Riyue Bao, Umamaheswar Duvvuri, Shaum Sridha, Seungwon Kim, M. Haroon Choudry, Matthew Holtzman, James Pingpank, James O'Toole, Richelle DeBlasio, Yang Jin, Quanquan Ding, Wentao Gao, Christopher Groetsch, Ornella Pagliano, Amy Rose, Corey Urban, Jagjit Singh, Prajan Divakar, David Mauro, Dmitri Bobilev, James Wooldridge, Arthur Krieg, Matthew Fury, Yana Najjar, Jason Luke, John Kirkwood, Janis Taube, Hyun Jung Park, Giorgio Trinchieri, Hassane Zarour
Intratumoral TLR9 agonists and anti-PD-1 provide durable clinical responses and broad immune activation. To evaluate efficacy and mechanisms of action of this combined treatment, we conducted a single-arm phase 2 neoadjuvant study of TLR9 agonist vid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96fa939bdab81718d5fc7c5cbad18f8b
https://doi.org/10.21203/rs.3.rs-2235839/v1
https://doi.org/10.21203/rs.3.rs-2235839/v1
Publikováno v:
The Review Review. 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc7a073b3963a557ad3a57085ffc1c51
https://doi.org/10.33972/trr.116
https://doi.org/10.33972/trr.116
Autor:
Marcela Gronda, Elisa Leung, Etienne Coyaud, Brian Raught, Aaron D. Schimmer, Neil MacLean, Alicia Cole, Fengshu Lin, Rachel Mattson, Walid A. Houry, Kevin R. Coombes, Rose Hurren, Zezhou Wang, Nianxiang Zhang, Mark D. Minden, Steven M. Kornblau, Yihua Qiu, Zenyaho Hao
Publikováno v:
Blood. 122:3937-3937
Caseinolytic protease (ClpP) is a mitochondrial enzyme complex with structural similarity to the cytoplasmic proteasome, but little is known about its function in the mitochondria. We identified ClpP as a potential therapeutic target for acute myeloi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95f2e47c772282c95eebe16161511a0b
https://doi.org/10.1182/blood.v122.21.3937.3937
https://doi.org/10.1182/blood.v122.21.3937.3937
Autor:
Elisa Leung, Neil MacLean, Marcela Gronda, Methvin Isaac, Mohan Babu, Mahadeo A. Sukhai, Walid A. Houry, Aaron D. Schimmer, Zezhou Wang, Fengshu Lin, Rose Hurren, Rachel Mattson, Alicia Cole
Publikováno v:
Blood. 120:3603-3603
Abstract 3603 The mammalian mitochondrial caseinolytic protease (mClpP) is a nuclear-encoded enzyme complex responsible for degrading excess proteins in the mitochondria. It is functionally similar to the proteasome complex in the cytoplasm and struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a7f59820973212d0957741671c8de3f
https://doi.org/10.1182/blood.v120.21.3603.3603
https://doi.org/10.1182/blood.v120.21.3603.3603
Autor:
Yi Hua Qia, Nianxian Zhang, Elisa Leung, Walid A. Houry, Mark D. Minden, Chang Jiang Xu, Rachel Mattson, Sonja Babovic, Marcela Gronda, Kevin R. Combes, Troy Ketela, Mahadeo A. Sukhai, Jason Moffat, Rose Hurren, Fengshu Lin, Shaheena Bashir, Rima Al-awar, John E. Dick, Veronique Voisin, Zhenyue Hao, Jean C.Y. Wang, Neil MacLean, Erno Wienholds, Etienne Coyaud, Xiaoming Wang, Wei Zheng, Ahmed Aman, Alicia Cole, Ashwin Ramakrishnan, Brian Raught, Gary D. Bader, Swayam Prabha, Steven M. Kornblau, Aaron D. Schimmer, Yulia Jitkova, Zezhou Wang, Connie J. Eaves, Ian Restall, Danny V. Jeyaraju
Publikováno v:
Cancer Cell. (6):864-876
SummaryFrom an shRNA screen, we identified ClpP as a member of the mitochondrial proteome whose knockdown reduced the viability of K562 leukemic cells. Expression of this mitochondrial protease that has structural similarity to the cytoplasmic proteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a36aa63861cb8cd810dbf1eefe360df