Výsledky vyhledávání - "Alicia C. Reid"

Autor: Randi B. Silver, Roberto Levi, Alicia C. Reid

Publikováno v: Immunological Reviews. 217:123-140

Cardiac mast cells proliferate in cardiovascular diseases. In myocardial ischemia, mast cell mediators contribute to coronary vasoconstriction, arrhythmias, leukocyte recruitment, and tissue injury and repair. Arrhythmic dysfunction, coronary vasocon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0705d9367190fdd12c2e9aba3bbaedb
https://doi.org/10.1111/j.1600-065x.2007.00514.x

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Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion

Autor: Seiichiro Kano, Nahid Seyedi, Alicia C. Reid, Ulrich Schäfer, Roberto Levi, Randi B. Silver, Takuji Machida, Christina J. Mackins

Publikováno v: Journal of Clinical Investigation. 116:1063-1070

Having identified renin in cardiac mast cells, we assessed whether its release leads to cardiac dysfunction. In Langendorff-perfused guinea pig hearts, mast cell degranulation with compound 48/80 released Ang I-forming activity. This activity was blo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8eaf01fd765fee6a115ec588d55774
https://doi.org/10.1172/jci25713

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Ectonucleoside Triphosphate Diphosphohydrolase1/CD39, Localized in Neurons of Human and Porcine Heart, Modulates ATP-Induced Norepinephrine Exocytosis

Autor: Alicia C. Reid, Takuji Machida, Randi B. Silver, M. Johan Broekman, Paul M. Heerdt, Ulrich Schäfer, Roberto Levi, Aaron J. Marcus

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 313:570-577

Using a guinea pig heart synaptosomal preparation, we previously observed that norepinephrine (NE) exocytosis was attenuated by a blockade of P2X purinoceptors, potentiated by inhibition of ectonucleoside triphosphate diphosphohydrolase-1 (E-NTPDase1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e95943c02e3b1497c58ced34992bec
https://doi.org/10.1124/jpet.104.081240

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Mast cells: A unique source of renin

Autor: Doris Herzlinger, Alicia C. Reid, Ulrich Schaefer, Roberto Levi, Randi B. Silver, Christina J. Mackins, Trevor Askwith

Publikováno v: Proceedings of the National Academy of Sciences. 101:13607-13612

In addition to the traditional renin–angiotensin system, a great deal of evidence favors the existence of numerous independent tissue-specific renin–angiotensin systems. We report that mast cells are an additional source of renin and constitute a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea0352a4518f3326819b134d6edd0ce
https://doi.org/10.1073/pnas.0403208101

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Histamine H3-Receptor-Induced Attenuation of Norepinephrine Exocytosis: A Decreased Protein Kinase A Activity Mediates a Reduction in Intracellular Calcium

Autor: Nahid Seyedi, Alicia C. Reid, Roberto Levi, Takuji Machida, Christina J. Mackins, Randi B. Silver

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 312:272-280

We had reported that activation of presynaptic histamine H(3)-receptors inhibits norepinephrine exocytosis from depolarized cardiac sympathetic nerve endings, an action associated with a marked decrease in intraneuronal Ca(2+) that we ascribed to a d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1769cb9e78e698fb0ef1ac8575a9009a
https://doi.org/10.1124/jpet.104.072504

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In vivo trans-splicing of 5′ and 3′ segments of Pre-mRNA directed by corresponding DNA sequences delivered by gene transfer

Autor: Neil R. Hackett, Robert G. Pergolizzi, André Menez, Randi B. Silver, Alexander E. Ropper, Katsutoshi Nakayama, Ronald G. Crystal, Rachel Dragos, Alicia C. Reid, Yadi Tan, Struhan H Coleman, John R. Ehteshami

Publikováno v: Molecular Therapy. 8(6):999-1008

We have developed a new paradigm of in vivo gene transfer termed "segmental trans-splicing" (STS), in which individual "donor" and "acceptor" DNA sequences, delivered in vitro or in vivo, generate pre-mRNAs with 5' and 3' splice signals, respectively

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Mast cells are required for the development of renal fibrosis in the rodent unilateral ureteral obstruction model

Autor: Nathan O'Connor, Alicia C. Reid, Thomas Maack, Diane Felsen, Racha Estephan, Rosalia Mora, Dix P. Poppas, Takashi Kameue, Jacqueline Brazin, Jie Chen, Arul Veerappan, Randi B. Silver, Surya V. Seshan

Mast cells are associated with inflammation and fibrosis. Whether they protect against or contribute to renal fibrosis is unclear. Based on our previous findings that mast cells can express and secrete active renin, and that angiotensin (ANG II) is p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ff79be3311014c7e9d45cc7775ac00
https://europepmc.org/articles/PMC3251335/

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Targeting cardiac mast cells: pharmacological modulation of the local renin-angiotensin system

Autor: Alicia C. Reid, Jacqueline Brazin, Christopher Morrey, Randi B. Silver, Roberto Levi

Publikováno v: Current pharmaceutical design. 17(34)

Enhanced production of angiotensin II and excessive release of norepinephrine in the ischemic heart are major causes of arrhythmias and sudden cardiac death. Mast cell-dependent mechanisms are pivotal in the local formation of angiotensin II and modu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec13c2894b10623377a5586acfa154d0
https://pubmed.ncbi.nlm.nih.gov/22103845

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