Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Alicia Buckler-White"'
Autor:
Guney Boso, Esther Shaffer, Qingping Liu, Kathryn Cavanna, Alicia Buckler-White, Christine A. Kozak
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Abstract Evolution of cellular innate immune genes in response to viral threats represents a rich area of study for understanding complex events that shape mammalian genomes. One of these genes, TRIM5, is a retroviral restriction factor that mediates
Externí odkaz:
https://doaj.org/article/94fb4a0c728645cebab8f5465a6d7e97
Publikováno v:
Viruses, Vol 10, Iss 8, p 418 (2018)
Naturally-occurring lymphomagenesis is induced by mouse leukemia viruses (MLVs) carried as endogenous retroviruses (ERVs). Replicating the ecotropic MLVs recombines with polytropic (P-ERVs) and xenotropic ERVs (X-ERVs) to generate pathogenic viruses
Externí odkaz:
https://doaj.org/article/382fb362c23b437286a18cfdec9de725
Autor:
Masashi Shingai, Sarah Welbourn, Jason M Brenchley, Priyamvada Acharya, Eri Miyagi, Ronald J Plishka, Alicia Buckler-White, Peter D Kwong, Yoshiaki Nishimura, Klaus Strebel, Malcolm A Martin
Publikováno v:
PLoS Pathogens, Vol 11, Iss 5, p e1004928 (2015)
For nearly 20 years, the principal biological function of the HIV-2/SIV Vpx gene has been thought to be required for optimal virus replication in myeloid cells. Mechanistically, this Vpx activity was recently reported to involve the degradation of St
Externí odkaz:
https://doaj.org/article/7382312e0a5a4f02aaf32f1c7b3281aa
Autor:
Fan Wu, Andrea Kirmaier, Robert Goeken, Ilnour Ourmanov, Laura Hall, Jennifer S Morgan, Kenta Matsuda, Alicia Buckler-White, Keiko Tomioka, Ronald Plishka, Sonya Whitted, Welkin Johnson, Vanessa M Hirsch
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8, p e1003577 (2013)
The antagonistic interaction with host restriction proteins is a major driver of evolutionary change for viruses. We previously reported that polymorphisms of the TRIM5α B30.2/SPRY domain impacted the level of SIVsmm viremia in rhesus macaques. Vire
Externí odkaz:
https://doaj.org/article/4e07c97e33b24134a67bed1a15b59390
Autor:
Andrea Kirmaier, Fan Wu, Ruchi M Newman, Laura R Hall, Jennifer S Morgan, Shelby O'Connor, Preston A Marx, Mareike Meythaler, Simoy Goldstein, Alicia Buckler-White, Amitinder Kaur, Vanessa M Hirsch, Welkin E Johnson
Publikováno v:
PLoS Biology, Vol 8, Iss 8, p e1000462 (2010)
Simian immunodeficiency viruses of sooty mangabeys (SIVsm) are the source of multiple, successful cross-species transmissions, having given rise to HIV-2 in humans, SIVmac in rhesus macaques, and SIVstm in stump-tailed macaques. Cellular assays and p
Externí odkaz:
https://doaj.org/article/2b323af8d509493d92d86801abf66822
Autor:
Bradley Sanville, Michael A Dolan, Kurt Wollenberg, Yuhe Yan, Carrie Martin, Man Lung Yeung, Klaus Strebel, Alicia Buckler-White, Christine A Kozak
Publikováno v:
PLoS Pathogens, Vol 6, p e1000974 (2010)
Mouse APOBEC3 (mA3) is a cytidine deaminase with antiviral activity. mA3 is linked to the Rfv3 virus resistance factor, a gene responsible for recovery from infection by Friend murine leukemia virus, and mA3 allelic variants differ in their ability t
Externí odkaz:
https://doaj.org/article/4634591db5864ad1b524021b7599cf05
Autor:
Takeo Kuwata, Yoshiaki Nishimura, Sonya Whitted, Ilnour Ourmanov, Charles R Brown, Que Dang, Alicia Buckler-White, Ranjini Iyengar, Jason M Brenchley, Vanessa M Hirsch
Publikováno v:
PLoS Pathogens, Vol 5, Iss 4, p e1000372 (2009)
The progressive decline of CD4(+) T cells is a hallmark of disease progression in human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection. Whereas the acute phase of the infection is dominated by virus-mediated depletion
Externí odkaz:
https://doaj.org/article/d1962e6ff9e24476927633e2aaa8c877
Autor:
Alicia Buckler-White, Christine A. Kozak, Katherine Fleck, Guney Boso, Qingping Liu, Samuel Carley
Publikováno v:
Mol Biol Evol
Vertebrate genomes contain endogenous retroviruses (ERVs) that represent remnants of past germline infections by ancient retroviruses. Despite comprising 8% of the human genome, the human ERVs (HERVs) do not encode a replication competent retrovirus.
Autor:
Richard A. Koup, Michel C. Nussenzweig, Yoshiaki Nishimura, Reza Sadjadpour, Sara Ferrando-Martinez, Malcolm A. Martin, Romas Geleziunas, Alicia Buckler-White, Rajeev Gautam, Olivia K. Donau, Eric Jesteadt, Joana Dias
Publikováno v:
The Journal of Experimental Medicine
Macaque recipients of anti–HIV-1 combination NAb treatment starting on PI day 3 or week 2 generate CD8+ cellular immunity that maintains durable suppression of SHIV replication and circulating CD4+ T cell levels during a 3–6-yr observation period
Autor:
Dean Follmann, Michel C. Nussenzweig, Malcolm A. Martin, Michael S. Seaman, Natalie Gaughan, Bruce J. Swihart, Yoshiaki Nishimura, Alicia Buckler-White, Till Schoofs, Anna Gazumyan, Rajeev Gautam
Publikováno v:
Nature Medicine. 24:610-616
In the absence of an effective and safe vaccine against HIV-1, the administration of broadly neutralizing antibodies (bNAbs) represents a logical alternative approach to prevent virus transmission. Here, we introduced two mutations encoding amino aci