Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Alicia Bort"'
Autor:
Inmaculada Ruz-Maldonado, John T. Gonzalez, Hanming Zhang, Jonathan Sun, Alicia Bort, Inamul Kabir, Richard G. Kibbey, Yajaira Suárez, Daniel M. Greif, Carlos Fernández-Hernando
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Midlobular hepatocytes are proposed to be the most plastic hepatic cell, providing a reservoir for hepatocyte proliferation during homeostasis and regeneration. However, other mechanisms beyond hyperplasia have been little explored and the c
Externí odkaz:
https://doaj.org/article/464ecf555656487594404e7c594fa8c7
Autor:
José María Mora-Rodríguez, Belén G. Sánchez, Alba Sebastián-Martín, Alba Díaz-Yuste, Manuel Sánchez-Chapado, Ana María Palacín, Carlos Sánchez-Rodríguez, Alicia Bort, Inés Díaz-Laviada
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15626 (2023)
In this study, we examined the metabolic adaptations of a chemoresistant prostate cancer cell line in comparison to a sensitive cell line. We utilized prostate cancer LNCaP cells and subjected them to a stepwise increase in the antiandrogen 2-hydroxy
Externí odkaz:
https://doaj.org/article/be6c89f5c41d48c0ba34f731483dc01e
Autor:
Alicia Bort, Belén G. Sánchez, Carlos León, Leonor Nozal, José M. Mora-Rodríguez, Florentina Castro, Antonio L. Crego, Inés Díaz-Laviada
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Chemoresistance is one of the most important challenges in cancer therapy. The presence of cancer stem cells within the tumor may contribute to chemotherapy resistance since these cells express high levels of extrusion pumps and xenobiotic metabolizi
Externí odkaz:
https://doaj.org/article/b575fc6f82784bbc88f4ca9cabb2e537
Autor:
Belén G. Sánchez, Alicia Bort, José María Mora-Rodríguez, Alba Díaz-Yuste, José Manuel Gasalla, Manuel Sánchez-Chapado, Alba Sebastián-Martín, Inés Díaz-Laviada
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2897 (2022)
Throughout the pandemic, serological assays have been revealed as crucial for detecting previous exposures to the virus and determining the timing of antibody maintenance after vaccination or natural infection. This study aimed to develop an optimize
Externí odkaz:
https://doaj.org/article/ae5f8b90c1174bb39c328b5ffcf3dd66
Autor:
Alicia Bort, Belén G. Sánchez, Pedro A. Mateos‐Gómez, Diana Vara‐Ciruelos, Nieves Rodríguez‐Henche, Inés Díaz‐Laviada
Publikováno v:
Molecular Oncology, Vol 13, Iss 5, Pp 1311-1331 (2019)
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. HCC treatment is hindered by the frequent emergence of chemoresistance to the multikinase inhibitor sorafenib, which has been related to the presence of cancer stem
Externí odkaz:
https://doaj.org/article/e8408f6e3e2247afa66d7c76d863ded4
Autor:
Belén G. Sánchez, Alicia Bort, Pedro A. Mateos-Gómez, Nieves Rodríguez-Henche, Inés Díaz-Laviada
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background Current chemotherapy for castration-resistant prostate cancer is established on taxane-based compounds like docetaxel. However, eventually, the development of toxic side effects and resistance limits the therapeutic benefit being
Externí odkaz:
https://doaj.org/article/d20b7b4fc2d54d669631da9dc77519d5
Autor:
Alba Sebastián-Martín, Belén G. Sánchez, José M. Mora-Rodríguez, Alicia Bort, Inés Díaz-Laviada
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 2026 (2022)
DPP4/CD26 is a single-pass transmembrane protein with multiple functions on glycemic control, cell migration and proliferation, and the immune system, among others. It has recently acquired an especial relevance due to the possibility to act as a rec
Externí odkaz:
https://doaj.org/article/9cf9d1b52d9040208d9b64d41dca29d7
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 329 (2022)
The natural bioactive compound capsaicin has been reported to have anticancer activity, although the underlying mechanism of action has not been completely clarified. Herein, we investigated the mechanism whereby capsaicin exerts antitumor effects on
Externí odkaz:
https://doaj.org/article/7a1d80093e2349f288e12ddb3e7703c8
Autor:
Alicia Bort, Belén G Sánchez, Elena Spínola, Pedro A Mateos-Gómez, Nieves Rodríguez-Henche, Inés Díaz-Laviada
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211420 (2019)
Capsaicin is a natural compound present in chili and red peppers and the responsible of their spicy flavor. It has recently provoked interest because of its antitumoral effects in many cell types although its action mechanism is not clearly understoo
Externí odkaz:
https://doaj.org/article/4a11297523a343c991573d5a09d49e7b
Publikováno v:
Cells, Vol 9, Iss 6, p 1441 (2020)
In the past few years, cell plasticity has emerged as a mode of targeted therapy evasion in prostate adenocarcinoma. When exposed to anticancer therapies, tumor cells may switch into a different histological subtype, such as the neuroendocrine phenot
Externí odkaz:
https://doaj.org/article/45a39ee69f474140a9a5567f1ee3b3ab