Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Alicia, Paini"'
Autor:
Elena Reale, Maryam Zare Jeddi, Alicia Paini, Alison Connolly, Radu Duca, Francesco Cubadda, Emilio Benfenati, Jos Bessems, Karen S. Galea, Hubert Dirven, Tiina Santonen, Holger M. Koch, Kate Jones, Craig Sams, Susana Viegas, Machera Kyriaki, Luca Campisi, Arthur David, Jean-Philippe Antignac, Nancy B Hopf
Publikováno v:
Environment International, Vol 184, Iss , Pp 108474- (2024)
Human health risk assessment is historically built upon animal testing, often following Organisation for Economic Co-operation and Development (OECD) test guidelines and exposure assessments. Using combinations of human relevant in vitro models, chem
Externí odkaz:
https://doaj.org/article/9df3893ac05a43d3b5774d94ced80469
Autor:
Maryam Zare Jeddi, Karen S. Galea, Susana Viegas, Peter Fantke, Henriqueta Louro, Jan Theunis, Eva Govarts, Sébastien Denys, Clémence Fillol, Loïc Rambaud, Marike Kolossa-Gehring, Tiina Santonen, Hilko van der Voet, Manosij Ghosh, Carla Costa, João Paulo Teixeira, Hans Verhagen, Radu-Corneliu Duca, An Van Nieuwenhuyse, Kate Jones, Craig Sams, Ovnair Sepai, Giovanna Tranfo, Martine Bakker, Nicole Palmen, Jacob van Klaveren, Paul T. J. Scheepers, Alicia Paini, Cristina Canova, Natalie von Goetz, Andromachi Katsonouri, Spyros Karakitsios, Dimosthenis A. Sarigiannis, Jos Bessems, Kyriaki Machera, Stuart Harrad, Nancy B. Hopf
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
The environmental impact on health is an inevitable by-product of human activity. Environmental health sciences is a multidisciplinary field addressing complex issues on how people are exposed to hazardous chemicals that can potentially affect advers
Externí odkaz:
https://doaj.org/article/04486a01bf6e4a41925232c7f2c2d258
Autor:
Giulia Russo, Elena Crispino, Emanuela Corsini, Martina Iulini, Alicia Paini, Andrew Worth, Francesco Pappalardo
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6172-6181 (2022)
In many domains regulating chemicals and chemical products, there is a legal requirement to determine skin sensitivity to allergens. While many in vitro assays to detect contact hypersensitivity have been developed as alternatives to animal testing o
Externí odkaz:
https://doaj.org/article/b601ddda47c84b5da6bd1a03ee32c972
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1764-1777 (2022)
Immunotoxicity hazard identification of chemicals aims to evaluate the potential for unintended effects of chemical exposure on the immune system. Perfluorinated alkylate substances (PFAS), such as perfluorooctane sulfonate (PFOS) and perfluorooctano
Externí odkaz:
https://doaj.org/article/4ab36813fa884879be6c785f8b6354f6
Autor:
Vanessa Baier, Alicia Paini, Stephan Schaller, Colin G. Scanes, Audrey J. Bone, Markus Ebeling, Thomas G. Preuss, Johannes Witt, David Heckmann
Publikováno v:
Environment International, Vol 169, Iss , Pp 107547- (2022)
Physiologically-based kinetic (PBK) models are effective tools for designing toxicological studies and conducting extrapolations to inform hazard characterization in risk assessment by filling data gaps and defining safe levels of chemicals. In the p
Externí odkaz:
https://doaj.org/article/538906f5c3854aa58c32c8940c07db7d
Autor:
Maryam Zare Jeddi, Nancy B. Hopf, Henriqueta Louro, Susana Viegas, Karen S. Galea, Robert Pasanen-Kase, Tiina Santonen, Vicente Mustieles, Mariana F. Fernandez, Hans Verhagen, Stephanie K. Bopp, Jean Philippe Antignac, Arthur David, Hans Mol, Robert Barouki, Karine Audouze, Radu-Corneliu Duca, Peter Fantke, Paul Scheepers, Manosij Ghosh, An Van Nieuwenhuyse, Joana Lobo Vicente, Xenia Trier, Loïc Rambaud, Clémence Fillol, Sebastien Denys, André Conrad, Marike Kolossa-Gehring, Alicia Paini, Jon Arnot, Florian Schulze, Kate Jones, Ovnair Sepai, Imran Ali, Lorraine Brennan, Emilio Benfenati, Francesco Cubadda, Alberto Mantovani, Alena Bartonova, Alison Connolly, Jaroslav Slobodnik, Yuri Bruinen de Bruin, Jacob van Klaveren, Nicole Palmen, Hubert Dirven, Trine Husøy, Cathrine Thomsen, Ana Virgolino, Martin Röösli, Tim Gant, Natalie von Goetz, Jos Bessems
Publikováno v:
Environment International, Vol 168, Iss , Pp 107476- (2022)
Human biomonitoring (HBM) is a crucial approach for exposure assessment, as emphasised in the European Commission’s Chemicals Strategy for Sustainability (CSS). HBM can help to improve chemical policies in five major key areas: (1) assessing intern
Externí odkaz:
https://doaj.org/article/2d6161886d324294b45844fc5a746cde
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
A computational workflow which integrates physiologically based kinetic (PBK) modelling; global sensitivity analysis (GSA), Approximate Bayesian Computation (ABC), Markov Chain Monte Carlo (MCMC) simulation and the Virtual Cell Based Assay (VCBA) for
Externí odkaz:
https://doaj.org/article/9cc8e7c1080e4660acc92544c7e0995b
Autor:
Kiara Fairman, Me-Kyoung Choi, Pavani Gonnabathula, Annie Lumen, Andrew Worth, Alicia Paini, Miao Li
Publikováno v:
Toxics, Vol 11, Iss 2, p 126 (2023)
A physiologically-based pharmacokinetic (PBPK) model represents the structural components of the body with physiologically relevant compartments connected via blood flow rates described by mathematical equations to determine drug disposition. PBPK mo
Externí odkaz:
https://doaj.org/article/ca537ecca68e4da38cc6693664d220b0
Autor:
Kyeonghee Monica Lee, Richard Corley, Annie M. Jarabek, Nicole Kleinstreuer, Alicia Paini, Andreas O. Stucki, Shannon Bell
Publikováno v:
Toxics, Vol 10, Iss 12, p 760 (2022)
New approach methodologies (NAMs) are emerging chemical safety assessment tools consisting of in vitro and in silico (computational) methodologies intended to reduce, refine, or replace (3R) various in vivo animal testing methods traditionally used f
Externí odkaz:
https://doaj.org/article/3b6b58359df3489993c72a96cf9e262e
Autor:
Laure-Alix Clerbaux, Alicia Paini, Annie Lumen, Hanan Osman-Ponchet, Andrew P. Worth, Olivier Fardel
Publikováno v:
Environment International, Vol 126, Iss , Pp 659-671 (2019)
Humans are continuously exposed to low levels of thousands of industrial chemicals, most of which are poorly characterised in terms of their potential toxicity. The new paradigm in chemical risk assessment (CRA) aims to rely on animal-free testing, w
Externí odkaz:
https://doaj.org/article/7ddc93b6846c4ef2b1a0e5b667028536