Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Alice Y Ting"'
Autor:
Kelvin F Cho, Shawn M Gillespie, Nicholas A Kalogriopoulos, Michael A Quezada, Martin Jacko, Michelle Monje, Alice Y Ting
Publikováno v:
eLife, Vol 11 (2022)
Technologies for detecting cell-cell contacts are powerful tools for studying a wide range of biological processes, from neuronal signaling to cancer-immune interactions within the tumor microenvironment. Here, we report TRACC (Transcriptional Readou
Externí odkaz:
https://doaj.org/article/ba21240dbd5f4fa98d5721e296c4f39a
Autor:
Robert Coukos, David Yao, Mateo I Sanchez, Eric T Strand, Meagan E Olive, Namrata D Udeshi, Jonathan S Weissman, Steven A Carr, Michael C Bassik, Alice Y Ting
Publikováno v:
eLife, Vol 10 (2021)
The trafficking of specific protein cohorts to correct subcellular locations at correct times is essential for every signaling and regulatory process in biology. Gene perturbation screens could provide a powerful approach to probe the molecular mecha
Externí odkaz:
https://doaj.org/article/6d814cb3a91342cea81c16b1402d48aa
Autor:
Laura Bozal-Basterra, María Gonzalez-Santamarta, Veronica Muratore, Aitor Bermejo-Arteagabeitia, Carolina Da Fonseca, Orhi Barroso-Gomila, Mikel Azkargorta, Ibon Iloro, Olatz Pampliega, Ricardo Andrade, Natalia Martín-Martín, Tess C Branon, Alice Y Ting, Jose A Rodríguez, Arkaitz Carracedo, Felix Elortza, James D Sutherland, Rosa Barrio
Publikováno v:
eLife, Vol 9 (2020)
Primary cilia are sensory organelles crucial for cell signaling during development and organ homeostasis. Cilia arise from centrosomes and their formation and function is governed by numerous factors. Through our studies on Townes-Brocks Syndrome (TB
Externí odkaz:
https://doaj.org/article/c27ce6e24a7a418aa67995364ccbfea1
Publikováno v:
eLife, Vol 8 (2019)
Defining specific protein interactions and spatially or temporally restricted local proteomes improves our understanding of all cellular processes, but obtaining such data is challenging, especially for rare proteins, cell types, or events. Proximity
Externí odkaz:
https://doaj.org/article/983bf42352a94c7ebbd0cbde5e8c3ec1
Autor:
Victoria Hung, Stephanie S Lam, Namrata D Udeshi, Tanya Svinkina, Gaelen Guzman, Vamsi K Mootha, Steven A Carr, Alice Y Ting
Publikováno v:
eLife, Vol 8 (2019)
Externí odkaz:
https://doaj.org/article/e2c8242efe58494c8470675ce55a3bf2
Publikováno v:
eLife, Vol 8 (2019)
Technologies that convert transient protein-protein interactions (PPIs) into stable expression of a reporter gene are useful for genetic selections, high-throughput screening, and multiplexing with omics technologies. We previously reported SPARK (Ki
Externí odkaz:
https://doaj.org/article/641acd926a6c41269c61c365c72d7c8c
Publikováno v:
eLife, Vol 6 (2017)
The spatial organization of RNA within cells is a crucial factor influencing a wide range of biological functions throughout all kingdoms of life. However, a general understanding of RNA localization has been hindered by a lack of simple, high-throug
Externí odkaz:
https://doaj.org/article/87937a28b4ce4872b428be61b44e7ef8
Publikováno v:
eLife, Vol 6 (2017)
Transcriptional assays, such as yeast two-hybrid and TANGO, that convert transient protein-protein interactions (PPIs) into stable expression of transgenes are powerful tools for PPI discovery, screens, and analysis of cell populations. However, such
Externí odkaz:
https://doaj.org/article/d5701a7f59494c7e9b4396ab7f6032a5
Autor:
Victoria Hung, Stephanie S Lam, Namrata D Udeshi, Tanya Svinkina, Gaelen Guzman, Vamsi K Mootha, Steven A Carr, Alice Y Ting
Publikováno v:
eLife, Vol 6 (2017)
The cytosol-facing membranes of cellular organelles contain proteins that enable signal transduction, regulation of morphology and trafficking, protein import and export, and other specialized processes. Discovery of these proteins by traditional bio
Externí odkaz:
https://doaj.org/article/3c04e0d0fea24685aae4dc58868f4272
Autor:
Xiaoliang Liu, Patricia T. Yam, Sabrina Schlienger, Eva Cai, Jingyi Zhang, Wei-Ju Chen, Oscar Torres Gutierrez, Vanesa Jimenez Amilburu, Vasanth Ramamurthy, Alice Y. Ting, Tess C. Branon, Michel Cayouette, Risako Gen, Tessa Marks, Jennifer H. Kong, Frédéric Charron, Xuecai Ge
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Hedgehog (Hh) signaling relies on the primary cilium, a cell surface organelle that serves as a signaling hub for the cell. Using proximity labeling and quantitative proteomics, we identify Numb as a ciliary protein that positively regulates
Externí odkaz:
https://doaj.org/article/2ea380e3064e409d898c47ae199e2954