Výsledky vyhledávání - "Alice Witsell"

Akademický článek

Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair.

Autor: Kelly Beagan, Robin L Armstrong, Alice Witsell, Upasana Roy, Nikolai Renedo, Amy E Baker, Orlando D Schärer, Mitch McVey

Publikováno v: PLoS Genetics, Vol 13, Iss 5, p e1006813 (2017)

Double strand breaks (DSBs) and interstrand crosslinks (ICLs) are toxic DNA lesions that can be repaired through multiple pathways, some of which involve shared proteins. One of these proteins, DNA Polymerase θ (Pol θ), coordinates a mutagenic DSB

Externí odkaz: https://doaj.org/article/424f94cfac564df49822bba40c3fbed3

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Super-sized deletions: Improved transposon excision screens using a mus309 mutant background

Autor: Daniel P. Kane, Mitch McVey, Alice Witsell

Publikováno v: Fly. 4:137-140

Over the past two decades, a large collection of transposable elements inserted at various locations in the Drosophila melanogaster genome has been assembled. These transposons are frequently utilized in imprecise excision screens to generate deletio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8891d1997b957ca15e94595ce04f03
https://doi.org/10.4161/fly.4.2.10918

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Senescence of human skeletal muscle impairs the local inflammatory cytokine response to acute eccentric exercise

Autor: Alice Witsell, Koichiro Hamada, Edouard Vannier, Ronenn Roubenoff, Jennifer M. Sacheck

Publikováno v: The FASEB Journal. 19:1-19

The impact of aging on the cytokine response of human skeletal muscle to exercise-induced injury remains poorly understood. We enrolled physically active, young (23-35 years old, n=15) and old (66-78 years old, n=15) men to perform 45 min of downhill

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a40e8d82c865d351880e0172670d4cf
https://doi.org/10.1096/fj.03-1286fje

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Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair

Autor: Alice Witsell, Amy Baker, Robin L. Armstrong, Orlando D. Schärer, Nikolai Renedo, Kelly Beagan, Upasana Roy, Mitch McVey

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 13, Iss 5, p e1006813 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f2609ce2308a4b84876695aecdc55f
https://doi.org/10.1371/journal.pgen.1006813

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Host Conditioning With 5-Fluorouracil and kit-Ligand to Provide for Long-Term Bone Marrow Engraftment

Autor: Peter Mauch, Donald Dawes, Alice Witsell, Ronald van Os, John M.K. Mislow

Publikováno v: Blood. 89:2376-2383

Administration of kit-ligand (KL) before and after doses of 5-fluorouracil (5-FU) results in marrow failure in mice, presumably because of enhanced KL-induced cycling of stem cells, which makes them more susceptible to the effects of 5-FU. In attempt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99274ce14e5e4675d0fe5bb3ae2ded2a
https://doi.org/10.1182/blood.v89.7.2376

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Hematopoietic stem cells in the blood after stem cell factor and interleukin-11 administration: evidence for different mechanisms of mobilization

Autor: Peter Mauch, Alice Witsell, Samuel J. Goldman, Clare Lamont, Tamlyn Neben, Charlene Quinto

Publikováno v: Blood. 86:4674-4680

Peripheral blood stem cells and progenitor cells, collected during recovery from exposure to cytotoxic agents or after cytokine administration, are being increasingly used in clinical bone marrow transplantation. To determine factors important for mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95dcdaaf783e005a6d67c14e354c504c
https://doi.org/10.1182/blood.v86.12.4674.bloodjournal86124674

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Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila

Autor: Martha J. Lundell, R. Brent Calder, Alice Witsell, Moonsook Lee, Robert N. Salomon, Mitch McVey, Justine S. Liepkalns, Ana Maria Garcia, Jan Vijg

Publikováno v: Genome Biology

Background The BLM DNA helicase plays a vital role in maintaining genome stability. Mutations in BLM cause Bloom syndrome, a rare disorder associated with cancer predisposition and premature aging. Humans and mice with blm mutations have increased fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfc35d707f1084c4a08889d7505ac82
https://pubmed.ncbi.nlm.nih.gov/22183041

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Removal of the Bloom Syndrome DNA Helicase Extends the Utility of Imprecise Transposon Excision for Making Null Mutations in Drosophila

Autor: Daniel P. Kane, Alice Witsell, Sarah Rubin, Mitch McVey

Transposable elements are frequently used in Drosophila melanogaster for imprecise excision screens to delete genes of interest. However, these screens are highly variable in the number and size of deletions that are recovered. Here, we show that con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bd67a75f528360f68048056e6160ea
https://europepmc.org/articles/PMC2778970/

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