Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alice Ward Racca"'
Autor:
Jin-Kyu Park, Yibing Qyang, Jonas Schwan, Michael J. Rynkiewicz, Alice Ward Racca, Daniel Jacoby, Jeffrey R. Moore, Lorenzo R. Sewanan, Stuart G. Campbell, Nikolaos Papoutsidakis, William Lehman
Publikováno v:
Journal of General Physiology. 153
Hypertrophic cardiomyopathy (HCM) is an inherited disorder caused primarily by mutations to thick and thinfilament proteins. Although thin filament mutations are less prevalent than their oft-studied thick filament counterparts, they are frequently a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9141ea56c84c857ca17f3dfaf2774ca5
https://doi.org/10.1085/jgp.202012640
https://doi.org/10.1085/jgp.202012640
Autor:
Corrado Poggesi, Chiara Tesi, Alice Ward Racca, Michael R. Hoopmann, Cecilia Ferrantini, J. Manuel Pioner, Lil Pabon, Jordan M. Klaiman, Veronica Muskheli, Michael Regnier, Xuan Guan, Martin K. Childers, Deok Ho Kim, David L. Mack, Charles E. Murry, Robert L. Moritz, Jesse Macadangdang
Publikováno v:
Cardiovasc Res
Aims Heart failure invariably affects patients with various forms of muscular dystrophy (MD), but the onset and molecular sequelae of altered structure and function resulting from full-length dystrophin (Dp427) deficiency in MD heart tissue are poorl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa9fb5abd4a2adc986d89a05cb4b53d
https://doi.org/10.1093/cvr/cvz109
https://doi.org/10.1093/cvr/cvz109
Autor:
Michael J. Rynkiewicz, Alice Ward Racca, Nicholas LaFave, William Lehman, Jeffrey R. Moore, Anita Ghosh
Publikováno v:
J Biol Chem
Dilated cardiomyopathy (DCM) is associated with mutations in cardiomyocyte sarcomeric proteins, including α-tropomyosin. In conjunction with troponin, tropomyosin shifts to regulate actomyosin interactions. Tropomyosin molecules overlap via tropomyo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526d69195ffc9bc76168213e079a60f1
https://pubmed.ncbi.nlm.nih.gov/33020181
https://pubmed.ncbi.nlm.nih.gov/33020181
Autor:
J. Manuel Pioner, Michael J. Bamshad, Anita E. Beck, Alice Ward Racca, Farid Moussavi-Harami, Yuanhua Cheng, Michael Regnier, Jordan M. Klaiman
Publikováno v:
The Journal of Physiology. 594:437-452
The contractile properties of human fetal cardiac muscle have not yet been described and functional information has been primarily obtained via studies in vivo with echocardiography. Most of what is known about the contractile properties of developin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9df5fc51fd16f68d70c53f5b62f883a
https://doi.org/10.1113/jp271290
https://doi.org/10.1113/jp271290
Autor:
Jeffrey R. Moore, Stephanie Jones, Michael J. Rynkiewicz, William Lehman, Nicholas LaFave, Alice Ward Racca
Publikováno v:
Biophysical Journal. 116:178a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97a6a34be45c85988b9c0c6998540745
https://doi.org/10.1016/j.bpj.2018.11.989
https://doi.org/10.1016/j.bpj.2018.11.989
Autor:
Kai Chun Yang, Rebecca J. Zaunbrecher, Chiara Tesi, Mark Y. Jeong, Deok Ho Kim, Josè Manuel Pioner, Jordan M. Klaiman, Alice Ward Racca, David L. Mack, Charles E. Murry, Martin K. Childers, Lil Pabon, Corrado Poggesi, Michael Regnier, Veronica Muskheli, Xuan Guan, Jesse Macadangdang
Publikováno v:
Stem Cell Reports, Vol 6, Iss 6, Pp 885-896 (2016)
Stem Cell Reports
Stem Cell Reports
Summary Tension production and contractile properties are poorly characterized aspects of excitation-contraction coupling of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Previous approaches have been limited due to the smal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be627a85caeb998014f5f9c5d9625d11
http://hdl.handle.net/2158/1048856
http://hdl.handle.net/2158/1048856
Autor:
Michael Regnier, F. Steven Korte, Margaret J. McMillin, Michael J. Bamshad, Alice Ward Racca, Anita E. Beck
Distal arthrogryposis is the most common known heritable cause of congenital contractures (e.g. clubfoot) and results from mutations in genes that encode proteins of the contractile complex of skeletal muscle cells. Mutations are most frequently foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459366725d4d509f5ad01339e1d74e44
https://europepmc.org/articles/PMC4481580/
https://europepmc.org/articles/PMC4481580/
Autor:
Veronica Muskheli, Christian I. Childers, Xuan Guan, Corrado Poggesi, Lil Pabon, Alice Ward Racca, Charles E. Murry, David L. Mack, Michael Regnier, Jesse Macadangdang, Mark Y. Jeong, Deok Ho Kim, Josè Manuel Pioner, Martin K. Childers
Publikováno v:
Biophysical Journal. 108(2)
Duchenne Muscular Dystrophy (DMD) is a wasting disease of striated muscle resulting from membrane fragility. We modeled DMD cardiac disease using urine-derived cells from a patient, reprogrammed to induced pluripotent stem cells (hiPSCs) and differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc35f728bbcbe466ab04a535462b29f
Publikováno v:
Biophysical Journal. 106(2)
Embryonic (MYH3), perinatal (MYH8), and alpha (MYH6) myosin heavy chains are predominantly expressed during prenatal development of human skeletal and cardiac muscle and may be upregulated following injury. To determine how mutations in these genes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f557c2c4fe5d80c136f4e8ce8a9eb378
Publikováno v:
Biophysical Journal. 106:771a
The mechanisms underlying most forms of Distal Arthrogryposis (DA), a group of congenital contracture syndromes, are unknown. Our previous functional studies from adult individuals with DA caused by the heterozygous embryonic myosin heavy chain mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb50b3655740c12323b9a8844269577
https://doi.org/10.1016/j.bpj.2013.11.4233
https://doi.org/10.1016/j.bpj.2013.11.4233