Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Alice V. Bakker"'
Autor:
William J Dower, Angie Inkyung Park, Alice V Bakker, Steven E Cwirla, Praechompoo Pongtornpipat, Blake M Williams, Prarthana Joshi, Bryan A Baxter, Michael C Needels, Ronald W Barrett
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0286834 (2023)
Interleukin (IL)-7 is broadly active on T-cell populations, and modified versions have been clinically evaluated for a variety of therapeutic applications, including cancer, lymphopenia, and infectious diseases; and found to be relatively well-tolera
Externí odkaz:
https://doaj.org/article/3bd59ccdb97e4f0fb8a0e9145823542e
Autor:
William J. Dower, Angie Inkyung Park, Alice V. Bakker, Steven E. Cwirla, Praechompoo Pongtornpipat, Blake M. Williams, Prarthana Joshi, Bryan A. Baxter, Michael C. Needels, Ronald W. Barrett
Interleukin (IL)-7 is broadly active on T-cell populations, and modified versions have been clinically evaluated for a variety of therapeutic applications, including cancer, lymphopenia and infectious diseases; and found to be relatively well-tolerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ff65917a24a1a813fbc673b68412542
https://doi.org/10.1101/2023.05.24.542196
https://doi.org/10.1101/2023.05.24.542196
Autor:
Angie I. Park, Steven E. Cwirla, Alice V. Bakker, Blake M. Williams, Prarthana Joshi, Praechompoo Pongtornpipat, Sandra M. Wang, Bryan Baxter, Michael C. Needels, Ronald W. Barrett, William J. Dower
Publikováno v:
Cancer Research. 82:2066-2066
Background: IL-7 receptor activation is essential for the proper development and homeostasis of T-cell subpopulations, and maintenance of the TCR clonal repertoire. Emerging evidence indicates potential clinical utility of IL-7 for immunotherapy of l
Autor:
Rebecca Williams, Robert A. Volkmann, Alice V. Bakker, Robin W. Spencer, W. Stephen Faraci, V. John Jasys, Michael S. Kellogg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2271-2276
Novel 3,2,0 bicyclic β-lactam sulfenamides and selected carbon isosteres are inhibitors of human leukocyte elastase. The comparative biological activity and hydrolytic stability of these compounds are described.
Publikováno v:
Biochemical Journal. 291:369-374
Despite limiting side-effects, lithium is the drug of choice for the treatment of bipolar depression. Its action may be due, in part, to its ability to dampen phosphatidylinositol turnover by inhibiting myo-inositol monophosphatase. Beryllium has bee
Autor:
Fredric J. Vinick, Arthur Adam Nagel, June Daffeh, Alice V. Bakker, Robin W. Spencer, Lawrence A. Vincent, Stanley Jung, W. Stephen Faraci
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 1:585-590
Inhibition of prolyl endopeptidase by Z-cyclohexyl prolinal and Z-indolinyl prolinal occurs with slow, tight binding inhibition and K i values of 2 – 3 nM. In vivo enzyme inhibition is also observed with a half time for recovery of enzyme activity
Publikováno v:
Biochemical Journal. 271:559-562
Prolyl endopeptidase is a serine proteinase that specifically cleaves peptides on the carboxy side of proline residues. Wilk & Orlowski [(1983) J. Neurochem. 41, 69-75] have shown that benzyloxycarbonyl-prolyl-prolinal (Z-prolyl-prolinal) is a potent