Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Alice Taubes"'
Autor:
Manish D. Paranjpe, Stella Belonwu, Jason K. Wang, Tomiko Oskotsky, Aarzu Gupta, Alice Taubes, Kelly A. Zalocusky, Ishan Paranjpe, Benjamin S. Glicksberg, Yadong Huang, Marina Sirota
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in the United States. In spite of evidence of females having a greater lifetime risk of developing Alzheimer’s Disease (AD) and
Externí odkaz:
https://doaj.org/article/f1b7beddceb6441c8e1f093b0d584ed2
Autor:
Ramsey Najm, Kelly A. Zalocusky, Misha Zilberter, Seo Yeon Yoon, Yanxia Hao, Nicole Koutsodendris, Maxine Nelson, Antara Rao, Alice Taubes, Emily A. Jones, Yadong Huang
Publikováno v:
Cell Reports, Vol 32, Iss 4, Pp 107962- (2020)
Summary: Despite its clear impact on Alzheimer’s disease (AD) risk, apolipoprotein (apo) E4’s contributions to AD etiology remain poorly understood. Progress in answering this and other questions in AD research has been limited by an inability to
Externí odkaz:
https://doaj.org/article/f1316fb3a2d5436abc74d71efac9cd01
Autor:
Yadong Huang, Alice Taubes, Marina Sirota, Tomiko Oskotsky, Misha Zilberter, Seo Yeon Yoon, Maureen E. Balestra, Jessica K De Freitas, Krishna Choudhary, Mesude Bicak, Benjamin S. Glicksberg, Brian P. Grone, Yanxia Hao, William Chang, Bin Chen, Ishan Paranjpe, Alice An, Celine Wang, Phil Nova, Emily Jones, Nuo Chen, Kelly A. Zalocusky, Nicole Koutsodendris, Fayzan Chaudhry, Silvia Pineda, Idit Kosti
Publikováno v:
Nature Aging. 1:932-947
The evident genetic, pathological and clinical heterogeneity of Alzheimer’s disease (AD) poses challenges for traditional drug development. We conducted a computational drug-repurposing screen for drugs to treat apolipoprotein E4 (APOE4)-related AD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::344ed394816c2d740eafbb790b588598
https://doi.org/10.1038/s43587-021-00122-7
https://doi.org/10.1038/s43587-021-00122-7
Autor:
Alice, Taubes, Phil, Nova, Kelly A, Zalocusky, Idit, Kosti, Mesude, Bicak, Misha Y, Zilberter, Yanxia, Hao, Seo Yeon, Yoon, Tomiko, Oskotsky, Silvia, Pineda, Bin, Chen, Emily A Aery, Jones, Krishna, Choudhary, Brian, Grone, Maureen E, Balestra, Fayzan, Chaudhry, Ishan, Paranjpe, Jessica, De Freitas, Nicole, Koutsodendris, Nuo, Chen, Celine, Wang, William, Chang, Alice, An, Benjamin S, Glicksberg, Marina, Sirota, Yadong, Huang
Publikováno v:
Nat Aging
The evident genetic, pathological, and clinical heterogeneity of Alzheimer’s disease (AD) poses challenges for traditional drug development. We conducted a computational drug repurposing screen for drugs to treat apolipoprotein (apo) E4-related AD.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::280579c1090f3d62b13565055133fa5b
https://pubmed.ncbi.nlm.nih.gov/36172600
https://pubmed.ncbi.nlm.nih.gov/36172600
Autor:
Maxine Nelson, Yadong Huang, Seo Yeon Yoon, Dah-Eun J Amornkul, Kelly A. Zalocusky, Alice An, Antara Rao, Nicole Koutsodendris, Olga Cisne-Thomson, Jason Bant, David A. Bennett, Qin Xu, Yanxia Hao, Ramsey Najm, Alice Taubes
Publikováno v:
Nature neuroscience, vol 24, iss 6
Selective neurodegeneration is a critical causal factor in Alzheimer's disease (AD); however, the mechanisms that lead some neurons to perish, whereas others remain resilient, are unknown. We sought potential drivers of this selective vulnerability u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a02ccbc05aec0ca64aa09e92e099b2
https://doi.org/10.1038/s41593-021-00851-3
https://doi.org/10.1038/s41593-021-00851-3
Autor:
Caroline Warly Solsberg, Tomiko Oskotsky, Stella Belonwu, Marina Sirota, Daniel G. Bunis, Kelly A. Zalocusky, Arjun A. Rao, Brian P. Grone, Gabriela K. Fragiadakis, Yaqiao Li, Alice Taubes, Yadong Huang
Alzheimer’s Disease (AD) is a complex neurodegenerative disease that gravely affects patients and imposes an immense burden on caregivers. Apolipoprotein E4 (APOE4) has been identified as the most common genetic risk factor for AD, yet the molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57e0d71997a906ef9da48fb61905ee75
https://doi.org/10.21203/rs.3.rs-291648/v1
https://doi.org/10.21203/rs.3.rs-291648/v1
Autor:
Manish D. Paranjpe, Stella Belonwu, Jason K. Wang, Tomiko Oskotsky, Aarzu Gupta, Alice Taubes, Kelly A. Zalocusky, Ishan Paranjpe, Benjamin S. Glicksberg, Yadong Huang, Marina Sirota
Publikováno v:
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience, Vol 13 (2021)
Frontiers in Aging Neuroscience, Vol 13 (2021)
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in the United States. In spite of evidence of females having a greater lifetime risk of developing Alzheimer’s Disease (AD) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a3abfc7b7272fcce77c4ca986e3cdf
https://doi.org/10.1101/2020.04.24.060558
https://doi.org/10.1101/2020.04.24.060558
Autor:
Seo Yeon Yoon, Yanxia Hao, Yadong Huang, Misha Zilberter, Kelly A. Zalocusky, Antara Rao, Maxine Nelson, Emily Jones, Alice Taubes, Nicole Koutsodendris, Ramsey Najm
Publikováno v:
SSRN Electronic Journal.
Despite its clear impact on Alzheimer’s Disease (AD) risk, apolipoprotein (apo) E4’s contributions to AD etiology remain poorly understood. Progress in answering this and other questions in AD research has been limited by an inability to model hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::230a55c6b54153b06deb200cb3614b65
https://doi.org/10.2139/ssrn.3545529
https://doi.org/10.2139/ssrn.3545529
Autor:
Marina Sirota, Alice An, Yadong Huang, Alice Taubes, Celine Wang, Phil Nova, Bin Chen, Tomiko Oskotsky, Maureen E. Balestra, Mesude Bicak, Yanxia Hao, Krishna Choudhary, Kelly A. Zalocusky, Benjamin S. Glicksberg, Ishan Paranjpe, Idit Kosti, Seo Yeon Yoon, Jessica K De Freitas, Nuo Chen, Fayzan Chaudhry, William Chang, Nicole Koutsodendris, Misha Zilberter, Emily Jones, Silvia Pineda, Brian P. Grone
Publikováno v:
Nature Aging. 1:1202-1202
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ea2c837eb6e79ee5f2fa2ecb961d38b
https://doi.org/10.1038/s43587-021-00144-1
https://doi.org/10.1038/s43587-021-00144-1
Publikováno v:
Trends Pharmacol Sci
Computational drug repurposing has the ability to remarkably reduce drug development time and cost in an era where these factors are prohibitively high. Several examples of successful repurposed drugs exist in fields such as oncology, diabetes, lepro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c601ecef0a6b137fe539c659641d1585
https://pubmed.ncbi.nlm.nih.gov/31326236
https://pubmed.ncbi.nlm.nih.gov/31326236