Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Alice Sosic"'
Autor:
Alice Sosic, Francesco Frecentese, Giulia Olivato, Daniele Rollo, Caterina Carraro, Elia Gamba, Vincenzo Santagada, Barbara Gatto
Publikováno v:
Viruses, Vol 14, Iss 10, p 2133 (2022)
2,6-dipeptidyl-anthraquinones are polycyclic planar systems substituted at opposite ring positions by short aminoacyl side chains. Derivatives with positively charged terminal amino acids showed in vitro inhibition of HIV-1 nucleocapsid (NC) protein
Externí odkaz:
https://doaj.org/article/b36a53a00cba473d94b124b80a9a30b3
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 582 (2022)
After a long limbo, RNA has gained its credibility as a druggable target, fully earning its deserved role in the next generation of pharmaceutical R&D. We have recently probed the trans-activation response (TAR) element, an RNA stem–bulge–loop do
Externí odkaz:
https://doaj.org/article/048df07c2e274fd6adcb5f4b27cfd1c7
Publikováno v:
Molecules, Vol 26, Iss 7, p 1874 (2021)
Specific RNA sequences regulate functions essential to life. The Trans-Activation Response element (TAR) is an RNA stem–bulge–loop structure involved in several steps of HIV-1 replication. In this work, we show how RNA targeting can inhibit HIV-1
Externí odkaz:
https://doaj.org/article/f3527f9303274e92be19f155f99a1b3b
Publikováno v:
Sensors, Vol 13, Iss 10, Pp 13425-13438 (2013)
In this work we have developed a multiplex microarray system capable of detecting VEGF165 and thrombin. We recently described a Sandwich Aptamer Microarray (SAM) for thrombin detection feasible for use in multiplex microarrays; here we describe a new
Externí odkaz:
https://doaj.org/article/a3b9bffd8f9d4ba28c6a12d329bcf97c
Publikováno v:
Sensors, Vol 11, Iss 10, Pp 9426-9441 (2011)
We have developed an aptamer-based microarray for human thrombin detection exploiting two non-overlapping DNA thrombin aptamers recognizing different exosites of the target protein. The 15-mer aptamer (TBA1) binds the fibrinogen-binding site, whereas
Externí odkaz:
https://doaj.org/article/b4d3b27a949d47adadd0acf104ca31fb
Publikováno v:
Journal of Visualized Experiments.
Autor:
Emanuele Fornasier, Maria Ludovica Macchia, Gabriele Giachin, Alice Sosic, Matteo Pavan, Mattia Sturlese, Cristiano Salata, Stefano Moro, Barbara Gatto, Massimo Bellanda, Roberto Battistutta
Publikováno v:
'Acta Crystallographica D ', vol: 78, pages: 363-378 (2022)
The SARS-CoV-2 main protease (Mpro) has a pivotal role in mediating viral genome replication and transcription of the coronavirus, making it a promising target for drugs against the COVID-19 pandemic. Here, a crystal structure is presented in which M
Autor:
Léa El Khoury, Zhifeng Jing, Alberto Cuzzolin, Alessandro Deplano, Daniele Loco, Boris Sattarov, Florent Hédin, Sebastian Wendeborn, Chris Ho, Dina El Ahdab, Theo Jaffrelot Inizan, Mattia Sturlese, Alice Sosic, Martina Volpiana, Angela Lugato, Marco Barone, Barbara Gatto, Maria Ludovica Macchia, Massimo Bellanda, Roberto Battistutta, Cristiano Salata, Ivan Kondratov, Rustam Iminov, Andrii Khairulin, Yaroslav Mykhalonok, Anton Pochepko, Volodymyr Chashka-Ratushnyi, Iaroslava Kos, Stefano Moro, Matthieu Montes, Pengyu Ren, Jay W. Ponder, Louis Lagardère, Jean-Philip Piquemal, Davide Sabbadin
Publikováno v:
Chemical Science
Chemical Science, 2022, ⟨10.1039/D1SC05892D⟩
Chemical Science, 2022, ⟨10.1039/D1SC05892D⟩
We report a fast-track computationally-driven discovery of new SARS-CoV2 Main Protease (Mpro) inhibitors whose potency range from mM for initial non-covalent ligands to high nM for the final covalent compound (IC50=830 +/- 50 nM). The project extensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fb3c770ad5b156560e839423dea37d
https://hal.science/hal-03361062
https://hal.science/hal-03361062
Autor:
Benedetta Fongaro, Elia Cappelletto, Alice Sosic, Barbara Spolaore, Patrizia Polverino de Laureto
Parkinson's disease (PD) is a chronic multifactorial disease, whose etiology is not completely understood. The amyloid aggregation of α-synuclein (Syn) is considered a major cause in the development of the disease. The presence of genetic mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86b3cb22e325590f967778f33b5267d
http://hdl.handle.net/11577/3451218
http://hdl.handle.net/11577/3451218
Autor:
Alice Sosic, Alexander Francke, Barbara Gatto, Richard Göttlich, Valentina Gandin, Michele De Franco, Tim Helbing, Caterina Carraro
Publikováno v:
Chemmedchem
In this study, we describe the synthesis and biological evaluation of a set of bis‐3‐chloropiperidines (B−CePs) containing rigid aromatic linker structures. A modification of the synthetic strategy also enabled the synthesis of a pilot tris‐3