Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Alice Sijts"'
Autor:
Ariana Barbera Betancourt, Qingkang Lyu, Femke Broere, Alice Sijts, Victor P. M. G. Rutten, Willem van Eden
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Failing immunological tolerance for critical self-antigens is the problem underlying most chronic inflammatory diseases of humans. Despite the success of novel immunosuppressive biological drugs, the so-called biologics, in the treatment of diseases
Externí odkaz:
https://doaj.org/article/3bf12aa1b85b447d89e47b49a7549a09
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95378 (2014)
Proteasomes play a fundamental role in intracellular protein degradation and therewith regulate a variety of cellular processes. Exposure of cells to (pro)inflammatory cytokines upregulates the expression of three inducible catalytic proteasome subun
Externí odkaz:
https://doaj.org/article/6256ed97b95a40d49593c2a16a355e7b
Publikováno v:
International review of cell and molecular biology. 369
The recent clinical approval of different Bi-specific antibodies (BsAbs) has revealed the great therapeutic potential of this novel class of biologicals. For example, the bispecific T-cell engager (BiTE), Blinatumomab, demonstrated the unique capacit
Publikováno v:
Molecular Immunology. 150:2
Publikováno v:
Scopus-Elsevier
Publons
Europe PubMed Central
Publons
Europe PubMed Central
Listeria monocytogenes is an intracellular bacterium that elicits MHC class I-restricted CTL in infected mice. A major CTL specificity is the nonamer peptide p60 217-225, which is derived from the bacterial murein hydrolase p60 and presented by the H
Publikováno v:
Scopus-Elsevier
Listeria monocytogenes is an intracellular pathogen that enters the cytoplasm of infected cells by secreting listeriolysin (LLO), a protein that destroys the phagosomal membrane. In infected mice, LLO is a major Ag detected by protective, MHC class I
Autor:
Ulrike Seifert, Heike Liermann, Vito Racanelli, Anne Halenius, Manfred Wiese, Heiner Wedemeyer, Thomas Ruppert, Kay Rispeter, Peter Henklein, Alice Sijts, Hartmut Hengel, Peter-M. Kloetzel, Barbara Rehermann
Publikováno v:
The Journal of clinical investigation. 114(2)
The high incidence of hepatitis C virus (HCV) persistence raises the question of how HCV interferes with host immune responses. Studying a single-source HCV outbreak, we identified an HCV mutation that impaired correct carboxyterminal cleavage of an
Autor:
Chantal Meulenbroeks, Huib van Weelden, Victor Rutten, Ton Willemse, Alice Sijts, Dietmar Zaiss
Publikováno v:
The Journal of Immunology. 190:62.14-62.14
UVB exposure of the skin is associated with amelioration of inflammatory diseases, which has been shown to be mediated by activated Tregs. Since we have recently shown that Tregs, for optimal functioning, are dependent on signals induced by the EGF-l
Publikováno v:
Europe PubMed Central
Listeria monocytogenes is an intracellular pathogen that enters the cytoplasm of infected cells by secreting listeriolysin (LLO), a protein that destroys the phagosomal membrane. In infected mice, LLO is a major Ag detected by protective, MHC class I
Autor:
Neisig A, Roelse J, Alice Sijts, Ossendorp F, Mc, Feltkamp, Wm, Kast, Cj, Melief, Jj, Neefjes
Publikováno v:
Europe PubMed Central
The MHC-encoded transporter associated with Ag presentation (TAP) translocates peptides from the cytosol to the ER lumen, where association with MHC class I molecules occurs. The MHC class I/peptide complex is subsequently transported to the cell sur