Výsledky vyhledávání - "Alice R Walker"

Akademický článek

ALKBH7 Variant Related to Prostate Cancer Exhibits Altered Substrate Binding.

Autor: Alice R Walker, Pavel Silvestrov, Tina A Müller, Robert H Podolsky, Gregory Dyson, Robert P Hausinger, Gerardo Andrés Cisneros

Publikováno v: PLoS Computational Biology, Vol 13, Iss 2, p e1005345 (2017)

The search for prostate cancer biomarkers has received increased attention and several DNA repair related enzymes have been linked to this dysfunction. Here we report a targeted search for single nucleotide polymorphisms (SNPs) and functional impact

Externí odkaz: https://doaj.org/article/d2c949b3530f40688630c45a904a8f10

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Akademický článek

Genetically encoded green fluorescent sensor for probing sulfate transport activity of solute carrier family 26 member a2 (Slc26a2) protein

Autor: Cuixin Lai, Lina Yang, Vishaka Pathiranage, Ruizhao Wang, Fedor V. Subach, Alice R. Walker, Kiryl D. Piatkevich

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)

Abstract Genetically encoded fluorescent biosensors became indispensable tools for biological research, enabling real-time observation of physiological processes in live cells. Recent protein engineering efforts have resulted in the generation of a l

Externí odkaz: https://doaj.org/article/c2bd5b0fc912493db3eaef10e2dc2037

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Akademický článek

Simulation-guided engineering of split GFPs with efficient β-strand photodissociation

Autor: Yasmin Shamsudin, Alice R. Walker, Chey M. Jones, Todd J. Martínez, Steven G. Boxer

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)

Abstract Green fluorescent proteins (GFPs) are ubiquitous for protein tagging and live-cell imaging. Split-GFPs are widely used to study protein-protein interactions by fusing proteins of interest to split GFP fragments that create a fluorophore upon

Externí odkaz: https://doaj.org/article/202de622170e4f74acda34ee5dc07652

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Proton Transfer from a Photoacid to a Water Wire: First Principles Simulations and Fast Fluorescence Spectroscopy

Autor: Alice R. Walker, Michael D. Fayer, Todd J. Martínez, Jan Meisner, Boning Wu

Publikováno v: The Journal of Physical Chemistry B. 125:12539-12551

Proton transfer reactions are ubiquitous in chemistry, especially in aqueous solutions. We investigate photoinduced proton transfer between the photoacid 8-hydroxypyrene-1,3,6-trisulfonate (HPTS) and water using fast fluorescence spectroscopy and ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34dfb19e780d32c37d1f850b91b346e
https://doi.org/10.1021/acs.jpcb.1c07254

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Rational Design of the beta-Bulge Gate in a Green Fluorescent Protein Accelerates the Kinetics of Sulfate Sensing

Autor: Whitney S. Y. Ong, Ke Ji, Vishaka Pathiranage, Caden Maydew, Kiheon Baek, Rhiza Lyne E. Villones, Gabriele Meloni, Alice R. Walker, Sheel Dodani

Here, we report how the mutagenesis of the beta-bulge residues (D137 and W138) in mNeonGreen, a bright fluorescent protein, unlocks and tunes the anion preference at physiological pH for sulfate, resulting in the turn-off sensor SulfOFF-1. This unpre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba260a79b9489d60a0a93f6d75997863
https://doi.org/10.26434/chemrxiv-2022-t7vmq-v2

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Computational investigations of the excited state dynamics and quenching mechanisms of polycyclic aromatic hydrocarbon DNA adducts in solution

Autor: Solomon Yamoah Effah, W. K. D. N. Kaushalya, Mark A. Hix, Alice R. Walker

Synthetically modified fluorescent nucleotides (SFNs) are highly popular in a variety of experiments to explore biochemistry in molecular imaging, but their photodynamics and quenching mechanisms remain relatively unstudied computationally. We combin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4aafb049a564743c5ef2ce515ad17fa4
https://doi.org/10.26434/chemrxiv-2022-jrq2q

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Computational Investigations of Selected Enzymes From Two Iron and α–ketoglutarate–Dependent Families

Autor: G. Andrés Cisneros, Madison B. Berger, Erik A. Vázquez-Montelongo, Alice R. Walker

Publikováno v: Phys Chem Chem Phys

DNA alkylation is used as the key epigenetic mark in eukaryotes, however, most alkylation in DNA can result in deleterious effects. Therefore, this process needs to be tightly regulated. The enzymes of the AlkB and Ten-Eleven Translocation (TET) fami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe81b5c1e7e038338c73e5b604f92e27
https://europepmc.org/articles/PMC8516722/

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Proton Transfer from a Photoacid to Water: First Principles Simulations and Fast Fluorescence Spectroscopy

Autor: Jan Meisner, Todd J. Martínez, Alice R. Walker, Boning Wu, Michael D. Fayer

Proton transfer reactions are ubiquitous in chemistry, especially in aqueous solutions. We investigate photo-induced proton transfer between the photoacid 8-hydroxypyrene-1,3,6- trisulfonate (HPTS) and water using fast fluorescence spectroscopy and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b963f59f0d2d09e7c362f93dc2aa5cd8
https://doi.org/10.33774/chemrxiv-2021-cdzlk

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