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pro vyhledávání: '"Alice R Eddershaw"'
Autor:
Alice R Eddershaw, Karl Syson, Paul R. J. Davey, Gregory Hamm, Christopher D. Stubbs, Paul Clarkson, Elizabeth Underwood, Lucy V Edwardes
Publikováno v:
Biochemistry. 59:4775-4786
Protein arginine methyltransferases (PRMTs) are of great interest for the development of therapeutics due to their involvement in a number of malignancies, such as lung and colon cancer. PRMT5 catalyzes the formation of symmetrical dimethylarginine o
Autor:
Cheryl M. Koh, Christopher D. Stubbs, Puneet Khurana, Gavin W. Collie, Ian L. Dale, Alice R Eddershaw, Joseph Shaw, Fredrik Mauritzson, Tony Cheung, Arjan Snijder, Edward J. Hennessy, Christopher R. Phillips, Louise Barlind, Daniel O'Neill, Ana J. Narvaez
Publikováno v:
ACS Medicinal Chemistry Letters
Many small molecule inhibitors of the cMET receptor tyrosine kinase have been evaluated in clinical trials for the treatment of cancer and resistance-conferring mutations of cMET are beginning to be reported for a number of such compounds. There is n