Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Alice R, Burton"'
Autor:
Alice R. Burton, Stephane M. Guillaume, William S. Foster, Adam K. Wheatley, Danika L. Hill, Edward J. Carr, Michelle A. Linterman
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113745- (2024)
Externí odkaz:
https://doaj.org/article/719be920c7a04aaab4b62ce9d5d095b4
Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
Autor:
Nathalie M. Schmidt, Peter A. C. Wing, Mariana O. Diniz, Laura J. Pallett, Leo Swadling, James M. Harris, Alice R. Burton, Anna Jeffery-Smith, Nekisa Zakeri, Oliver E. Amin, Stephanie Kucykowicz, Mirjam H. Heemskerk, Brian Davidson, Tim Meyer, Joe Grove, Hans J. Stauss, Ines Pineda-Torra, Clare Jolly, Elizabeth C. Jury, Jane A. McKeating, Mala K. Maini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Shared metabolic pathways could allow simultaneous manipulation of T cells, viruses and tumours. Here the authors show targeting cholesterol esterification restrains hepatitis B in vitro, whilst bolstering exhausted antigen-specific T cell responses
Externí odkaz:
https://doaj.org/article/80c091a62a0e452aadda8e67b452162c
Autor:
Stephanie Kucykowicz, Oliver E. Amin, Alice R. Burton, Leo Swadling, Nathalie M. Schmidt, Nekisa Zakeri, Jessica Davies, Gloryanne Aidoo-Micah, Kerstin A. Stegmann, Nicholas J. Easom, Anna Jeffery-Smith, Mala K. Maini, Laura J. Pallett
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101356- (2022)
Summary: With the growing appreciation of tissue-resident immunity, studying tissue-specific immune cells contributing to both homeostasis and disease is imperative. Here, we provide a protocol for the isolation of human intrahepatic leukocytes (IHL)
Externí odkaz:
https://doaj.org/article/45abae595f3b493592066ff2dfbe21a4
Autor:
Anna Jeffery-Smith, Alice R. Burton, Sabela Lens, Chloe Rees-Spear, Jessica Davies, Monika Patel, Robin Gopal, Luke Muir, Felicity Aiano, Katie J. Doores, J. Yimmy Chow, Shamez N. Ladhani, Maria Zambon, Laura E. McCoy, Mala K. Maini
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
Memory B cells (MBCs) can provide a recall response able to supplement waning antibodies (Abs) with an affinity-matured response better able to neutralize variant viruses. We studied a cohort of elderly care home residents and younger staff (median a
Externí odkaz:
https://doaj.org/article/4e603982f9904faf8768698a2faaf045
Autor:
Laura J. Pallett, Leo Swadling, Mariana Diniz, Alexander A. Maini, Marius Schwabenland, Adrià Dalmau Gasull, Jessica Davies, Stephanie Kucykowicz, Jessica K. Skelton, Niclas Thomas, Nathalie M. Schmidt, Oliver E. Amin, Upkar S. Gill, Kerstin A. Stegmann, Alice R. Burton, Emily Stephenson, Gary Reynolds, Matt Whelan, Jenifer Sanchez, Roel de Maeyer, Clare Thakker, Kornelija Suveizdyte, Imran Uddin, Ana M. Ortega-Prieto, Charlotte Grant, Farid Froghi, Giuseppe Fusai, Sabela Lens, Sofia Pérez-del-Pulgar, Walid Al-Akkad, Giuseppe Mazza, Mahdad Noursadeghi, Arne Akbar, Patrick T. F. Kennedy, Brian R. Davidson, Marco Prinz, Benjamin M. Chain, Muzlifah Haniffa, Derek W. Gilroy, Marcus Dorner, Bertram Bengsch, Anna Schurich, Mala K. Maini
Publikováno v:
Nature. 614:334-342
Autor:
Leo Swadling, Laura J. Pallett, Mariana O. Diniz, Josephine M. Baker, Oliver E. Amin, Kerstin A. Stegmann, Alice R. Burton, Nathalie M. Schmidt, Anna Jeffery-Smith, Nekisa Zakeri, Kornelija Suveizdyte, Farid Froghi, Giuseppe Fusai, William M. Rosenberg, Brian R. Davidson, Anna Schurich, A. Katharina Simon, Mala K. Maini
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 687-698.e6 (2020)
Summary: Tissue-resident memory T cells have critical roles in long-term pathogen and tumor immune surveillance in the liver. We investigate the role of autophagy in equipping human memory T cells to acquire tissue residence and maintain functionalit
Externí odkaz:
https://doaj.org/article/424ef329fece490388a8227ae3fca83e
Autor:
Alyssa Silva-Cayetano, Sigrid Fra-Bido, Philippe A. Robert, Silvia Innocentin, Alice R. Burton, Emily M. Watson, Jia Le Lee, Louise M. C. Webb, William S. Foster, Ross C. J. McKenzie, Alexandre Bignon, Ine Vanderleyden, Dominik Alterauge, Julia P. Lemos, Edward J. Carr, Danika L. Hill, Isabella Cinti, Karl Balabanian, Dirk Baumjohann, Marion Espeli, Michael Meyer-Hermann, Alice E. Denton, Michelle A. Linterman
The magnitude and quality of the germinal center (GC) response decline with age, resulting in poor vaccine-induced immunity in older individuals. A functional GC requires the co-ordination of multiple cell types across time and space, in particular a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6af918521eb723049f1db70982a5b74
http://hdl.handle.net/10044/1/104428
http://hdl.handle.net/10044/1/104428
Autor:
Nicholas J. W. Easom, Kerstin A. Stegmann, Leo Swadling, Laura J. Pallett, Alice R. Burton, Dennis Odera, Nathalie Schmidt, Wei-Chen Huang, Giuseppe Fusai, Brian Davidson, Mala K. Maini
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
NK cells have potent antitumor capacity. They are enriched in the human liver, with a large subset specialized for tissue-residence. The potential for liver-resident versus liver-infiltrating NK cells to populate, and exert antitumor functions in, hu
Externí odkaz:
https://doaj.org/article/3b3fb65285bd43568678fc040c9bded3
Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
Autor:
Nekisa Zakeri, Anna Jeffery-Smith, Elizabeth C. Jury, Hans J. Stauss, Mariana O. Diniz, Oliver E. Amin, Jane A. McKeating, Nathalie M. Schmidt, Tim Meyer, Peter A C Wing, James Harris, Alice R Burton, Mala K. Maini, Brian R. Davidson, Mirjam H.M. Heemskerk, Stephanie Kucykowicz, Laura J. Pallett, Leo Swadling, Joe Grove, Ines Pineda-Torra, Clare Jolly
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Determining divergent metabolic requirements of T cells, and the viruses and tumours they fail to combat, could provide new therapeutic checkpoints. Inhibition of acyl-CoA:cholesterol acyltransferase (ACAT) has direct anti-carcinogenic activity. Here
Autor:
Jia Le Lee, Sigrid C. Fra‐Bido, Alice R. Burton, Silvia Innocentin, Danika L. Hill, Michelle A. Linterman
Publikováno v:
Aging cell. 21(9)
Vaccines typically protect against (re)infections by generating pathogen-neutralising antibodies. However, as we age, antibody-secreting cell formation and vaccine-induced antibody titres are reduced. Antibody-secreting plasma cells differentiate fro